Zobrazeno 1 - 10
of 191
pro vyhledávání: '"Lars, Thim"'
Autor:
Gert Bolt, Peter B. Johansen, Helle Heibroch Petersen, Henrik Rahbek-Nielsen, D. M. Karpf, Peder Lisby Nørby, Mette Loftager, Marianne Kjalke, Lars Thim, E. Bloem, G. E. Blouse
Publikováno v:
Journal of Thrombosis and Haemostasis. 17:350-360
Essentials Factor (F)VIII with an intermediate-length B-domain showed higher levels in murine gene therapy. FVIII with different B-domain lengths were analysed. FVIII variants with B-domains between 186 and 240 amino acids (aa) have extended half-lif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a71795725da862caf2148eb40463f37e
https://doi.org/10.1111/jth.14355
https://doi.org/10.1111/jth.14355
Autor:
Jens Madsen, Grith Lykke Sorensen, Ole Nielsen, Ida Tornøe, Lars Thim, Claus Fenger, Jan Mollenhauer, Uffe Holmskov
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64441 (2013)
The protein deleted in malignant brain tumors (DMBT1) and the trefoil factor (TFF) proteins have all been proposed to have roles in epithelial cell growth and cell differentiation and shown to be up regulated in inflammatory bowel diseases. A panel o
Externí odkaz:
https://doaj.org/article/0e2f460927a24fe89a837e5cdcd60831
Autor:
Gert Bolt, Jens Jacob Hansen, Ernst Broberg Hansen, Haleh Ahmadian, Lars Sejergaard, Lars Thim, Johan Karlsson, Johan H. Faber
Publikováno v:
Blood Coagulation & Fibrinolysis
Turoctocog alfa (NovoEight) is a third-generation recombinant factor VIII (rFVIII) with a truncated B-domain that is manufactured in Chinese hamster ovary cells. No human or animal-derived materials are used in the process. The aim of this study is t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e745c208bf48b09dc7eb1b9ceb0b213b
https://doi.org/10.1097/mbc.0000000000000477
https://doi.org/10.1097/mbc.0000000000000477
Autor:
Tobias N. Haase, Louise Torp Dalgaard, Louise Larsen, Annika Bagge, Louise Winkel, Morten Arendt Rasmussen, Jeanette Lykke, Dennis Back Holmgaard, Lars Thim, Jens Høiriis Nielsen
Publikováno v:
Islets. 10(3)
The endocrine pancreas expands markedly in the first postnatal days and the insulin producing β-cells initiate a functional maturation preceded by a morphological change of the islets of Langerhans. Trefoil factor 3 (TFF3) is a secreted peptide expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcfa9c21ff02472de3019c59c0fbe2c2
https://pubmed.ncbi.nlm.nih.gov/29723130
https://pubmed.ncbi.nlm.nih.gov/29723130
Autor:
Thomas Lund, Steen Seier Poulsen, Niels-Erik Viby, Ebba Nexo, Lars Egholm Pedersen, Vibeke Backer, Hannelouise Kissow, Lars Thim
Publikováno v:
The Clinical Respiratory Journal. 9:322-329
Objective Trefoil factor peptides (TFF) are secreted onto mucosal surfaces together with mucins and occur in high concentrations in pulmonary secretions from patients with chronic obstructive pulmonary disease (COPD). In the present study, we aimed t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fb491764146a008b47192e361565076
https://doi.org/10.1111/crj.12146
https://doi.org/10.1111/crj.12146
Autor:
Niels-Erik Viby, Jens J. Holst, Bolette Hartmann, Hannelouise Kissow, Lars Thim, Steen Seier Poulsen, Michael Timm
Publikováno v:
Cancer Chemotherapy and Pharmacology. 70:39-48
Gastrointestinal mucositis is an unwanted and often dose-limiting side effect to most cancer treatments. Glucagon-like peptide-2 (GLP-2) is a peptide secreted from intestinal L-cells in response to nutrient intake. The peptide is involved in the regu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2de595704977428019ccf62be42f6ffc
https://doi.org/10.1007/s00280-012-1882-2
https://doi.org/10.1007/s00280-012-1882-2
Autor:
J. Pedersen, Gert Bolt, Marianne Kjalke, Thomas N. Krogh, J. M. Petersen, Peder Lisby Nørby, Lars Thim, Thomas Dock Steenstrup, Brian Berg Stidsen Vandahl, Niels Kristian Klausen, Laust Bruun Johnsen, Johan Karlsson
Publikováno v:
Haemophilia. 16:349-359
SUMMARY A new recombinant factor VIII (FVIII), N8, has been produced in Chinese hamster ovary (CHO) cells. The molecule consists of a heavy chain of 88 kDa including a 21 amino acid residue truncated B-domain and a light chain of 79 kDa. The two chai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b539302c9c5fa896722471bb10f9d9ba
https://doi.org/10.1111/j.1365-2516.2009.02135.x
https://doi.org/10.1111/j.1365-2516.2009.02135.x
Publikováno v:
Acta Medica Scandinavica. 213:99-105
The primary structure of different insulins is reviewed and the properties, identification tests, purity, potency and immunogenicity of human insulin are summerized. Novo Research Institute has developed a method, simply using an enzymatic conversion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77ba2b66f247e4f03a1220073179460e
https://doi.org/10.1111/j.0954-6820.1983.tb08555.x
https://doi.org/10.1111/j.0954-6820.1983.tb08555.x
Publikováno v:
International Journal of Peptide and Protein Research. 30:379-387
Insulins and C-peptides were extracted and purified from bison and fox pancreatic glands. The insulins were reduced and pyridylethylated, and the derived A- and B-chains separated by HPLC. Amino acid sequence determinations of the pyridylethylated A-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60bc9b20b6f15327651c8bd7bebcc869
https://doi.org/10.1111/j.1399-3011.1987.tb03345.x
https://doi.org/10.1111/j.1399-3011.1987.tb03345.x
Publikováno v:
International Journal of Peptide and Protein Research. 26:70-77
Single chain des-(B30) insulin (SCI) has been synthesized from porcine insulin by trypsin in a medium with a low content of water. Trypsin catalyzes an intramolecular transpeptidation reaction in which the glycineA1 residue substitutes the alanineB30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17756c24b39ee7ed67250ba5764fbcb7
https://doi.org/10.1111/j.1399-3011.1985.tb03179.x
https://doi.org/10.1111/j.1399-3011.1985.tb03179.x