Výsledky vyhledávání - "Lars, Thelander"

De novo dNTP production is essential for normal postnatal murine heart development

Autor: Lars Thelander, Andrei Chabes, Jonas von Hofsten, Paolo Lorenzon, Per Stål, Phong Tran, Paolo Medini, Sushma Sharma, Paulina H. Wanrooij, Anna Karin Nilsson, Anna-Karin Olofsson

Publikováno v: Journal of Biological Chemistry. 294:15889-15897

The building blocks of DNA, dNTPs, can be produced de novo or can be salvaged from deoxyribonucleosides. However, to what extent the absence of de novo dNTP production can be compensated for by the salvage pathway is unknown. Here, we eliminated de n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f8af335fece9d85202c8cbfcd7309613
https://doi.org/10.1074/jbc.ra119.009492

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Trypanosoma brucei Thymidine Kinase Is Tandem Protein Consisting of Two Homologous Parts, Which Together Enable Efficient Substrate Binding

Autor: Sharvani Munender Vodnala, Farahnaz Ranjbarian, Lars Thelander, Reza Rofougaran, Munender Vodnala, Anders Hofer

Publikováno v: Journal of Biological Chemistry. 287:17628-17636

Trypanosoma brucei causes African sleeping sickness, a disease for which existing chemotherapies are limited by their toxicity or lack of efficacy. We have found that four parasites, including T. brucei, contain genes where two or four thymidine kina

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https://doi.org/10.1074/jbc.m112.340059

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The critical C-terminus of the small subunit of herpes simplex virus ribonucleotide reductase is mobile and conformationally similar to C-terminal peptides

Autor: Rolf Ingemarson, Norman Aubry, Michel Liuzzi, Lars Thelander, Steven R. LaPlante, Neil Moss

Publikováno v: International Journal of Peptide and Protein Research. 44:549-555

The C-terminus of the small subunit of class I ribonucleotide reductases is essential for subunit association and enzymatic activity. 1H NMR analysis of the small subunit (2 × 38 kDa as a homodimer) of herpes simplex virus ribonucleotide reductase s

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https://doi.org/10.1111/j.1399-3011.1994.tb01143.x

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p53R2-dependent Ribonucleotide Reduction Provides Deoxyribonucleotides in Quiescent Human Fibroblasts in the Absence of Induced DNA Damage

Autor: Lars Thelander, Peter Reichard, Vera Bianchi, Giovanna Pontarin, Paola Ferraro, Pelle Håkansson

Publikováno v: Journal of Biological Chemistry. 282:16820-16828

Human fibroblasts in culture obtain deoxynucleotides by de novo ribonucleotide reduction or by salvage of deoxynucleosides. In cycling cells the de novo pathway dominates, but in quiescent cells the salvage pathway becomes important. Two forms of act

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c81a1be47f5d707a7f8497ed85db9404
https://doi.org/10.1074/jbc.m701310200

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Expression, Purification, Characterization, and in Vivo Targeting of Trypanosome CTP Synthetase for Treatment of African Sleeping Sickness

Autor: Artur Fijolek, Anders Hofer, Lars Thelander

Publikováno v: Journal of Biological Chemistry. 282:11858-11865

African sleeping sickness is a fatal disease caused by two parasite subspecies: Trypanosoma brucei gambiense and T. b. rhodesiense. We previously reported that trypanosomes have extraordinary low CTP pools compared with mammalian cells. Trypanosomes

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https://doi.org/10.1074/jbc.m611580200

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10. Hydroxamic Acids and Other Hydroxylamine Derivatives as Inhibitors of DNA Synthesis

Autor: I. Kjøller Larsen, Lars Thelander, Britt-Marie Sjöberg

A series of simple hydroxamic acids was prepared and their inhibitory action on the protein B-12 was studied. The rate of reaction with Fremy’s salt (KOSO2)2N-0 was examined spectrophotometrically and correlated to hydroxyurea the parent compound.

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https://doi.org/10.1159/000430633

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The Schizosaccharomyces pombe Replication Inhibitor Spd1 Regulates Ribonucleotide Reductase Activity and dNTPs by Binding to the Large Cdc22 Subunit

Autor: Pelle Håkansson, Olga Chilkova, Lina Dahl, Lars Thelander, Vladimir Domkin

Publikováno v: Journal of Biological Chemistry. 281:1778-1783

Ribonucleotide reductase (RNR) is an essential enzyme that provides the cell with a balanced supply of deoxyribonucleoside triphosphates for DNA replication and repair. Mutations that affect the regulation of RNR in yeast and mammalian cells can lead

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c222c5eda5de682f3b7ea814c54a857
https://doi.org/10.1074/jbc.m511716200

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The Ribonucleotide Reductase R1 Homolog of Murine Cytomegalovirus Is Not a Functional Enzyme Subunit but Is Required for Pathogenesis

Autor: Lars Thelander, Wolfram Brune, Santo Landolfo, Maura Cornaglia, David Lembo, Ulrich H. Koszinowski, Manuela Donalisio, Anders Hofer

Publikováno v: Journal of Virology. 78:4278-4288

Ribonucleotide reductase (RNR) is the key enzyme in the biosynthesis of deoxyribonucleotides. Alpha- and gammaherpesviruses express a functional enzyme, since they code for both the R1 and the R2 subunits. By contrast, betaherpesviruses contain an op

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https://doi.org/10.1128/jvi.78.8.4278-4288.2004

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S Phase-specific Transcription of the Mouse Ribonucleotide Reductase R2 Gene Requires Both a Proximal Repressive E2F-binding Site and an Upstream Promoter Activating Region

Autor: Stefan Björklund, Anna Lena Chabes, Lars Thelander

Publikováno v: Journal of Biological Chemistry. 279:10796-10807

Ribonucleotide reductase is essential for supplying a balanced pool of the four deoxyribonucleotides required for DNA synthesis and repair. The active enzyme consists of two non-identical subunits called proteins R1 and R2. There are multiple levels

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https://doi.org/10.1074/jbc.m312482200

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