Feasibility to use whole-genome sequencing as a sole diagnostic method to detect genomic aberrations in pediatric B-cell acute lymphoblastic leukemia

Autor: Fatemah Rezayee, Jesper Eisfeldt, Aron Skaftason, Ingegerd Öfverholm, Shumaila Sayyab, Ann Christine Syvänen, Khurram Maqbool, Henrik Lilljebjörn, Bertil Johansson, Linda Olsson-Arvidsson, Christina Orsmark Pietras, Anna Staffas, Lars Palmqvist, Thoas Fioretos, Lucia Cavelier, Linda Fogelstrand, Jessica Nordlund, Valtteri Wirta, Richard Rosenquist, Gisela Barbany

Publikováno v: Frontiers in Oncology, Vol 13 (2023)

IntroductionThe suitability of whole-genome sequencing (WGS) as the sole method to detect clinically relevant genomic aberrations in B-cell acute lymphoblastic leukemia (ALL) was investigated with the aim of replacing current diagnostic methods.Metho

Externí odkaz: https://doaj.org/article/40bdae45ba894ef6ae31e5164ee7f34f

Aberrant MNX1 expression associated with t(7;12)(q36;p13) pediatric acute myeloid leukemia induces the disease through altering histone methylation

Autor: Ahmed Waraky, Anders Östlund, Tina Nilsson, Dieter Weichenhan, Pavlo Lutsik, Marion Bähr, Joschka Hey, Gürcan Tunali, Jenni Adamsson, Susanna Jacobsson, Mohammad Hamdy Abdelrazak Morsy, Susann Li, Linda Fogelstrand, Christoph Plass, Lars Palmqvist

Publikováno v: Haematologica, Vol 109, Iss 3 (2023)

Certain subtypes of acute myeloid leukemia (AML) in children have inferior outcome, such as AML with translocation t(7;12)(q36;p13) leading to an MNX1::ETV6 fusion along with high expression of MNX1. We have identified the transforming event in this

Externí odkaz: https://doaj.org/article/c09464f66fa34ff5804534e692be9f28

Concentration of the CDCP1 protein in human cord plasma may serve as a predictor of hematopoietic stem and progenitor cell content

Autor: Sofia Frändberg, Julia Asp, Berit Waldner, Jan Holgersson, Lars Palmqvist

Publikováno v: Stem Cell Research, Vol 29, Iss , Pp 24-27 (2018)

Successful hematopoietic stem and progenitor cell (HSPC) transplantation rests upon reliable methods for their enumeration in sources such as cord blood (CB). Methods used today are costly, time consuming and exhaust the limited number of cells neede

Externí odkaz: https://doaj.org/article/de11cf79486d4b9c87a710dfc7e0dc3d

Fusion transcript analysis reveals slower response kinetics than multiparameter flow cytometry in childhood acute myeloid leukaemia

Autor: Lene Karlsson, Charlotte Guldborg Nyvold, Anastasia Soboli, Pegah Johansson, Lars Palmqvist, Anne Tierens, Henrik Hasle, Birgitte Lausen, Ólafur Gisli Jónsson, Gitte Wulff Jürgensen, Lene Hyldahl Ebbesen, Jonas Abrahamsson, Linda Fogelstrand

Publikováno v: Karlsson, L, Nyvold, C G, Soboli, A, Johansson, P, Palmqvist, L, Tierens, A, Hasle, H, Lausen, B, Jónsson, Ó G, Jürgensen, G W, Ebbesen, L H, Abrahamsson, J & Fogelstrand, L 2022, ' Fusion transcript analysis reveals slower response kinetics than multiparameter flow cytometry in childhood acute myeloid leukaemia ', International Journal of Laboratory Hematology, vol. 44, no. 6, pp. 1094-1101 . https://doi.org/10.1111/ijlh.13935

Background: Analysis of measurable residual disease (MRD) is increasingly being implemented in the clinical care of children and adults with acute myeloid leukemia (AML). However, MRD methodologies differ and discordances in results lead to difficult

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::516f7521bad60e05af94db1ebe828c9b
https://doi.org/10.1111/ijlh.13935

Micro-ribonucleic acid-155 is a direct target of Meis1, but not a driver in acute myeloid leukemia

Autor: Edith Schneider, Anna Staffas, Linda Röhner, Erik D. Malmberg, Arghavan Ashouri, Kathrin Krowiorz, Nicole Pochert, Christina Miller, Stella Yuan Wei, Laleh Arabanian, Christian Buske, Hartmut Döhner, Lars Bullinger, Linda Fogelstrand, Michael Heuser, Konstanze Döhner, Ping Xiang, Jens Ruschmann, Oleh I. Petriv, Alireza Heravi-Moussavi, Carl L. Hansen, Martin Hirst, R. Keith Humphries, Arefeh Rouhi, Lars Palmqvist, Florian Kuchenbauer

Publikováno v: Haematologica, Vol 103, Iss 2 (2018)

Micro-ribonucleic acid-155 (miR-155) is one of the first described oncogenic miRNAs. Although multiple direct targets of miR-155 have been identified, it is not clear how it contributes to the pathogenesis of acute myeloid leukemia. We found miR-155

Externí odkaz: https://doaj.org/article/87401d72d1534be9b48a6f1e53390dbc