Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Lars, Faxälv"'
Publikováno v:
Platelets, Vol 34, Iss 1 (2023)
Pharmacological inhibition of the platelet ADP-receptor P2Y12 is a cornerstone in the prevention of atherothrombotic events in adult patients with acute coronary syndrome (ACS). Thienopyridines such as clopidogrel and prasugrel exert their antithromb
Externí odkaz:
https://doaj.org/article/e760f2e4c67d4a47b645b869275587b4
Publikováno v:
Platelets, Vol 29, Iss 5, Pp 512-519 (2018)
Platelet function disorders (PFDs) are common in patients with mild bleeding disorders (MBDs), yet the significance of laboratory findings suggestive of a PFD remain unclear due to the lack of evidence for a clinical correlation between the test resu
Externí odkaz:
https://doaj.org/article/eaaf4f9599e540e285b5e00b433cab46
Autor:
Ankit S. Macwan, Niklas Boknäs, Maria P. Ntzouni, Sofia Ramström, Jonathan M. Gibbins, Lars Faxälv, Tomas L. Lindahl
Publikováno v:
Haematologica, Vol 104, Iss 7 (2019)
As platelet activation is an irreversible and potentially harmful event, platelet stimulatory signaling must be tightly regulated to ensure the filtering-out of inconsequential fluctuations of agonist concentrations in the vascular milieu. Herein, we
Externí odkaz:
https://doaj.org/article/7411bea6610746999c8d5244d83d9193
Autor:
Abigail S McGovern, Pia Larsson, Volga Tarlac, Juan Nunez-Iglesias, Stephen Cody, Lars Faxälv, Justin R Hamilton, Niklas Boknäs
Publikováno v:
Blood. 140:1662-1663
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6dcd70467a7c73e0ba7113379a5e244
https://doi.org/10.1182/blood-2022-168838
https://doi.org/10.1182/blood-2022-168838
Publikováno v:
Biochemical Society Transactions. 44:35-39
Platelet-derived polyphosphates (polyP), stored in dense granule and released upon platelet activation, have been claimed to enhance thrombin activation of coagulation factor XI (FXI) and to activate FXII directly. The latter claim is controversial a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::673117f78038f15f37aa1b93e36531c4
https://doi.org/10.1042/bst20150220
https://doi.org/10.1042/bst20150220
Autor:
Ankit S, Macwan, Niklas, Boknäs, Maria P, Ntzouni, Sofia, Ramström, Jonathan M, Gibbins, Lars, Faxälv, Tomas L, Lindahl
Publikováno v:
Haematologica
As platelet activation is an irreversible and potentially harmful event, platelet stimulatory signaling must be tightly regulated to ensure the filtering-out of inconsequential fluctuations of agonist concentrations in the vascular milieu. Herein, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::440c0611959ee03b19ffc74fd90dabee
https://pubmed.ncbi.nlm.nih.gov/30630981
https://pubmed.ncbi.nlm.nih.gov/30630981
Publikováno v:
Thrombosis and Haemostasis
Imaging methods based on time-lapse microscopy are important tools for studying the dynamic events that shape thrombus formation upon vascular injury. However, there is a lack of methods to translate the vast amount of visual data generated in such e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c20cbbdb7d86d029f2d766599e37c03
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-150961
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-150961
Platelet function disorders (PFDs) are common in patients with mild bleeding disorders (MBDs), yet the clinical significance of laboratory findings suggestive of a PFD remain unclear due to the lack of evidence for a clear link between test results a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bb51df6121dd44bfe5ad3e641cb1887
Publikováno v:
Pigment Cell & Melanoma Research. 27:431-441
The proteinase-activated receptor 1 (PAR-1) plays a central role in melanoma progression and its expression level is believed to correlate with the degree of cancer invasiveness. Here, we show that PAR-1 is post-transcriptionally regulated by miR-20b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6c9f15651353f5a13328a7c4a292144
https://doi.org/10.1111/pcmr.12217
https://doi.org/10.1111/pcmr.12217
Autor:
Tomas L. Lindahl, Pentti Tengvall, Jakob O. Ström, Elvar Theodorsson, Sofia Ramström, Lars Faxälv, Niklas Boknäs
Publikováno v:
Blood. 122:3818-3824
The recent claim that stimulated platelets activate the intrinsic pathway of coagulation by the release of polyphosphates has been considered a breakthrough in hemostasis research. In little more than 3 years, the original publication by Müller et a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5a03a5a992a1a982dff37db052b11e9
https://doi.org/10.1182/blood-2013-05-499384
https://doi.org/10.1182/blood-2013-05-499384