Zobrazeno 1 - 10
of 548
pro vyhledávání: '"Lars, Farde"'
Autor:
Simon Ekman, Zsolt Cselényi, Andrea Varrone, Aurelija Jucaite, Heather Martin, Magnus Schou, Peter Johnström, Gianluca Laus, Rolf Lewensohn, Andrew P. Brown, Jasper van derAart, Karthick Vishwanathan, Lars Farde
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 6, Pp 955-965 (2023)
Abstract Brain metastases (BMs) are associated with poor prognosis in epidermal growth factor receptor mutation‐positive (EGFRm) non‐small cell lung cancer (NSCLC). Osimertinib is a third‐generation, irreversible, EGFR‐tyrosine kinase inhibit
Externí odkaz:
https://doaj.org/article/fe8e055f9652498db9a233ac1fdc48e7
Autor:
Maria Lee, Helena Fatouros-Bergman, Pontus Plavén-Sigray, Pauliina Ikonen Victorsson, Carl M. Sellgren, Sophie Erhardt, Lena Flyckt, Lars Farde, Simon Cervenka
Publikováno v:
npj Schizophrenia, Vol 7, Iss 1, Pp 1-7 (2021)
Abstract Cognitive impairment is an important predictor of disability in schizophrenia. Dopamine neurotransmission in cortical brain regions has been suggested to be of importance for higher-order cognitive processes. The aim of this study was to exa
Externí odkaz:
https://doaj.org/article/97839361cd674a3f8ef26c888c06933c
Publikováno v:
EJNMMI Research, Vol 10, Iss 1, Pp 1-11 (2020)
Abstract Background In positron emission tomography (PET) imaging, binding is typically estimated by fitting pharmacokinetic models to the series of measurements of radioactivity in the target tissue following intravenous injection of a radioligand.
Externí odkaz:
https://doaj.org/article/8a9f25973afc4807b87381b75b8f9608
Autor:
Zsolt Cselényi, Aurelija Jucaite, Cecilia Kristensson, Per Stenkrona, Pär Ewing, Andrea Varrone, Peter Johnström, Magnus Schou, Ana Vazquez-Romero, Mohammad Mahdi Moein, Martin Bolin, Jonathan Siikanen, Pär Grybäck, Bengt Larsson, Christer Halldin, Ken Grime, Ulf G. Eriksson, Lars Farde
Publikováno v:
EJNMMI Research, Vol 10, Iss 1, Pp 1-13 (2020)
Abstract Background The radioligand [11C]VC-002 was introduced in a small initial study long ago for imaging of muscarinic acetylcholine receptors (mAChRs) in human lungs using positron emission tomography (PET). The objectives of the present study i
Externí odkaz:
https://doaj.org/article/b57a1b395ada441a9bd3f59c5762420f
Autor:
Anton Lindberg, Ryosuke Arakawa, Tsuyoshi Nogami, Sangram Nag, Magnus Schou, Charles S. Elmore, Lars Farde, Victor W. Pike, Christer Halldin
Publikováno v:
EJNMMI Research, Vol 9, Iss 1, Pp 1-8 (2019)
Abstract Background Over the last decade, a few radioligands have been developed for PET imaging of brain 5-HT1B receptors. The 5-HT1B receptor is a G-protein-coupled receptor (GPCR) that exists in two different agonist affinity states. An agonist li
Externí odkaz:
https://doaj.org/article/10bc2306d18e432dbaa5a6c3fa933174
Autor:
Magnus Schou, Pär Ewing, Zsolt Cselenyi, Markus Fridén, Akihiro Takano, Christer Halldin, Lars Farde
Publikováno v:
EJNMMI Research, Vol 9, Iss 1, Pp 1-10 (2019)
Abstract Background Positron emission tomography (PET) is a non-invasive molecular imaging technique that traces the distribution of radiolabeled molecules in experimental animals and human subjects. We hypothesized that PET could be used to visualiz
Externí odkaz:
https://doaj.org/article/b5670c54e71a4432942d0c3a22be322f
Autor:
Mahabuba Jahan, Peter Johnström, Ram K. Selvaraju, Marie Svedberg, Maria Sörhede Winzell, Jenny Bernström, Lee Kingston, Magnus Schou, Zhisheng Jia, Stanko Skrtic, Lars Johansson, Olle Korsgren, Lars Farde, Christer Halldin, Olof Eriksson
Publikováno v:
EJNMMI Research, Vol 8, Iss 1, Pp 1-14 (2018)
Abstract Background The G-protein-coupled receptor 44 (GPR44) is a beta cell-restricted target that may serve as a marker for beta cell mass (BCM) given the development of a suitable PET ligand. Methods The binding characteristics of the selected can
Externí odkaz:
https://doaj.org/article/adeebd397411476c89f34e68e0105f08
Autor:
Pontus Plavén-Sigray, Granville James Matheson, Zsolt Cselényi, Aurelija Jucaite, Lars Farde, Simon Cervenka
Publikováno v:
EJNMMI Research, Vol 8, Iss 1, Pp 1-10 (2018)
Abstract Purpose The PET radioligand (R)-[11C]PK11195 is used to quantify the 18-kDa translocator protein (TSPO), a marker for glial activation. Since there is no brain region devoid of TSPO, an arterial input function (AIF) is ideally required for q
Externí odkaz:
https://doaj.org/article/14a6295bda984b289ae7eb4a4d2b7d5c
Autor:
Simon Jangard, Nitya Jayaram‐Lindström, Nils Hentati Isacsson, Granville James Matheson, Pontus Plavén‐Sigray, Johan Franck, Jacqueline Borg, Lars Farde, Simon Cervenka
Publikováno v:
Addiction. 118:1053-1061
Autor:
Tove Freiburghaus, Jonas E. Svensson, Granville J. Matheson, Pontus Plavén-Sigray, Johan Lundberg, Lars Farde, Simon Cervenka
Publikováno v:
NeuroImage, Vol 226, Iss , Pp 117523- (2021)
Dopamine D2 receptors (D2-R) in extrastriatal brain regions are of high interest for research in a wide range of psychiatric and neurologic disorders. Pharmacological competition studies and test–retest experiments have shown high validity and reli
Externí odkaz:
https://doaj.org/article/6490946b021843e5baa0c00c8c19b6cd