Zobrazeno 1 - 10
of 161
pro vyhledávání: '"Lars, Dölken"'
Autor:
Carina R. Hartmann, Robin Khan, Jennifer Schöning, Maximilian Richter, Maike Willers, Sabine Pirr, Julia Heckmann, Johannes Dirks, Henner Morbach, Monika Konrad, Elena Fries, Magdalene Winkler, Johanna Büchel, Silvia Seidenspinner, Jonas Fischer, Claudia Vollmuth, Martin Meinhardt, Janina Marissen, Mirco Schmolke, Sibylle Haid, Thomas Pietschmann, Simone Backes, Lars Dölken, Ulrike Löber, Thomas Keil, Peter U. Heuschmann, Achim Wöckel, Sagar, Thomas Ulas, Sofia K. Forslund-Startceva, Christoph Härtel, Dorothee Viemann
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionRespiratory viral infections (RVIs) are a major global contributor to morbidity and mortality. The susceptibility and outcome of RVIs are strongly age-dependent and show considerable inter-population differences, pointing to genetically a
Externí odkaz:
https://doaj.org/article/9f360bbb7f334dfd8f295291a1345444
Autor:
Marie Schöl, Rebekka Schempp, Thomas Hennig, Dominik Wigger, Fabian Schumacher, Burkhard Kleuser, Christian Stigloher, Marco van Ham, Lothar Jänsch, Sibylle Schneider-Schaulies, Lars Dölken, Elita Avota
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Ceramides generated by the activity of the neutral sphingomyelinase 2 (nSMase2) play a pivotal role in stress responses in mammalian cells. Dysregulation of sphingolipid metabolism has been implicated in numerous inflammation-related pathologies. How
Externí odkaz:
https://doaj.org/article/41085d444af749728f9be4c34902f5ed
Autor:
Carolin Gerke, Liane Bauersfeld, Ivo Schirmeister, Chiara Noemi-Marie Mireisz, Valerie Oberhardt, Lea Mery, Di Wu, Christopher Sebastian Jürges, Robbert M Spaapen, Claudio Mussolino, Vu Thuy Khanh Le-Trilling, Mirko Trilling, Lars Dölken, Wolfgang Paster, Florian Erhard, Maike Hofmann, Andreas Schlosser, Hartmut Hengel, Frank Momburg, Anne Halenius
Publikováno v:
eLife, Vol 13 (2024)
Human leucocyte antigen class I (HLA-I) molecules play a central role for both NK and T-cell responses that prevent serious human cytomegalovirus (HCMV) disease. To create opportunities for viral spread, several HCMV-encoded immunoevasins employ dive
Externí odkaz:
https://doaj.org/article/c867fd290b5f4af9870c2dc3f63a87b4
Autor:
Bibiana Costa, Jennifer Becker, Tobias Krammer, Felix Mulenge, Verónica Durán, Andreas Pavlou, Olivia Luise Gern, Xiaojing Chu, Yang Li, Luka Čičin-Šain, Britta Eiz-Vesper, Martin Messerle, Lars Dölken, Antoine-Emmanuel Saliba, Florian Erhard, Ulrich Kalinke
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Human cytomegalovirus (HCMV) is a widespread pathogen that in immunocompromised hosts can cause life-threatening disease. Studying HCMV-exposed monocyte-derived dendritic cells by single-cell RNA sequencing, we observe that most cells are en
Externí odkaz:
https://doaj.org/article/7e57f2fc99c0427a90c6d097bb173ff7
Autor:
Lara Djakovic, Thomas Hennig, Katharina Reinisch, Andrea Milić, Adam W. Whisnant, Katharina Wolf, Elena Weiß, Tobias Haas, Arnhild Grothey, Christopher S. Jürges, Michael Kluge, Elmar Wolf, Florian Erhard, Caroline C. Friedel, Lars Dölken
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Herpes simplex virus 1 (HSV-1) infection and stress responses disrupt transcription termination by RNA Polymerase II (Pol II). In HSV-1 infection, but not upon salt or heat stress, this is accompanied by a dramatic increase in chromatin acce
Externí odkaz:
https://doaj.org/article/88c94da7658643c8abd946d207f3dd82
Autor:
Patrick Vogel, Martin Andreas Rückert, Bernhard Friedrich, Rainer Tietze, Stefan Lyer, Thomas Kampf, Thomas Hennig, Lars Dölken, Christoph Alexiou, Volker Christian Behr
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
Sensitive methods for antibody detection tend to be expensive and slow. Here, the authors report a magnetic particle spectroscopy method named COMPASS, as a rapid and low-cost technique which is comparable to ELISA in terms of sensitivity but with a
Externí odkaz:
https://doaj.org/article/dce94727e94b4459a9345b1fc92a61b3
Autor:
Manivel Lodha, Ihsan Muchsin, Christopher Jürges, Vanda Juranic Lisnic, Anne L'Hernault, Andrzej J Rutkowski, Bhupesh K Prusty, Arnhild Grothey, Andrea Milic, Thomas Hennig, Stipan Jonjic, Caroline C Friedel, Florian Erhard, Lars Dölken
Publikováno v:
PLoS Pathogens, Vol 19, Iss 5, p e1010992 (2023)
The genomes of both human cytomegalovirus (HCMV) and murine cytomegalovirus (MCMV) were first sequenced over 20 years ago. Similar to HCMV, the MCMV genome had initially been proposed to harbor ≈170 open reading frames (ORFs). More recently, omics
Externí odkaz:
https://doaj.org/article/ea5dbdd681fa4ad6a528c084c981f79a
Autor:
Chris David Lauruschkat, Ihsan Muchsin, Alice Rein, Florian Erhard, Denise Grathwohl, Lars Dölken, Carolin Köchel, Christine Susanne Falk, Hermann Einsele, Sebastian Wurster, Götz Ulrich Grigoleit, Sabrina Kraus
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionHuman cytomegalovirus (HCMV) causes significant morbidity and mortality in allogeneic stem cell transplant (alloSCT) recipients. Recently, antiviral letermovir prophylaxis during the first 100 days after alloSCT replaced PCR-guided preemp
Externí odkaz:
https://doaj.org/article/2fc7ef57f2ff4e4eab17aff5d14e1a6f
Autor:
Adam W. Whisnant, Christopher S. Jürges, Thomas Hennig, Emanuel Wyler, Bhupesh Prusty, Andrzej J. Rutkowski, Anne L’hernault, Lara Djakovic, Margarete Göbel, Kristina Döring, Jennifer Menegatti, Robin Antrobus, Nicholas J. Matheson, Florian W. H. Künzig, Guido Mastrobuoni, Chris Bielow, Stefan Kempa, Chunguang Liang, Thomas Dandekar, Ralf Zimmer, Markus Landthaler, Friedrich Grässer, Paul J. Lehner, Caroline C. Friedel, Florian Erhard, Lars Dölken
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Here, using computational integration of multi-omics data, the authors provide a detailed transcriptome and translatome of herpes simplex virus 1 (HSV-1), including previously unidentified ORFs and N-terminal extensions. The study also provides a HSV
Externí odkaz:
https://doaj.org/article/2bc69e036d254f1f89647997e0dbd0b2
Autor:
Xiuye Wang, Thomas Hennig, Adam W. Whisnant, Florian Erhard, Bhupesh K. Prusty, Caroline C. Friedel, Elmira Forouzmand, William Hu, Luke Erber, Yue Chen, Rozanne M. Sandri-Goldin, Lars Dölken, Yongsheng Shi
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Herpes simplex virus-1 (HSV-1) infection disrupts transcription termination (DoTT) of host genes, but underlying mechanisms are unclear. Here, Wang et al. show that the HSV-1 immediate early protein ICP27 induces DoTT through interaction with the mRN
Externí odkaz:
https://doaj.org/article/86795a19df404ef6a9b5cb941f4f5451