Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Lars, Bräutigam"'
Autor:
Christina Wilms, Klaudia Lepka, Felix Häberlein, Steven Edwards, Jörg Felsberg, Linda Pudelko, Tobias T. Lindenberg, Gereon Poschmann, Nan Qin, Katrin Volbracht, Tim Prozorovski, Sven G. Meuth, Ulf D. Kahlert, Marc Remke, Orhan Aktas, Guido Reifenberger, Lars Bräutigam, Benjamin Odermatt, Carsten Berndt
Publikováno v:
Redox Biology, Vol 49, Iss , Pp 102221- (2022)
Redox regulation of specific cysteines via oxidoreductases of the thioredoxin family is increasingly being recognized as an important signaling pathway. Here, we demonstrate that the cytosolic isoform of the vertebrate-specific oxidoreductase Glutare
Externí odkaz:
https://doaj.org/article/2e1d65566877484caf8912ee69a75699
Autor:
Guotao Peng, Hanna M. Sinkko, Harri Alenius, Neus Lozano, Kostas Kostarelos, Lars Bräutigam, Bengt Fadeel
Publikováno v:
Nature Nanotechnology. 18:42-48
The gut microbiome produces metabolites that interact with the aryl hydrocarbon receptor (AhR), a key regulator of immune homoeostasis in the gut1,2. Here we show that oral exposure to graphene oxide (GO) modulates the composition of the gut microbio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52b0e4b40304a0ea60b37c1a37fd4de0
https://doi.org/10.1038/s41565-022-01260-8
https://doi.org/10.1038/s41565-022-01260-8
Autor:
Lars Bräutigam, Jie Zhang, Kristian Dreij, Linda Spahiu, Arne Holmgren, Hiroshi Abe, Kenneth D. Tew, Danyelle M. Townsend, Michael J. Kelner, Ralf Morgenstern, Katarina Johansson
Publikováno v:
Redox Biology, Vol 17, Iss , Pp 171-179 (2018)
We show for the first time that, in contrast to other glutathione transferases and peroxidases, deletion of microsomal glutathione transferase 1 (MGST1) in mice is embryonic lethal. To elucidate why, we used zebrafish development as a model system an
Externí odkaz:
https://doaj.org/article/6112082f1b8143d8bfa088eb5a31f32c
Autor:
Thomas Helleday, Pål Stenmark, Ulrika Warpman Berglund, Carsten Berndt, Evert Homan, Jordi Carreras Puigvert, Stella Karsten, Robert Gustafsson, Mohit Narwal, Helge Gad, Ann-Sofie Jemth, Linda Pudelko, Lars Bräutigam
Cancer cells are commonly in a state of redox imbalance that drives their growth and survival. To compensate for oxidative stress induced by the tumor redox environment, cancer cells upregulate specific nononcogenic addiction enzymes, such as MTH1 (N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22df73fc0905aa412d6ad8a9fe08060b
https://doi.org/10.1158/0008-5472.c.6507759
https://doi.org/10.1158/0008-5472.c.6507759
Autor:
Thomas Helleday, Pål Stenmark, Ulrika Warpman Berglund, Carsten Berndt, Evert Homan, Jordi Carreras Puigvert, Stella Karsten, Robert Gustafsson, Mohit Narwal, Helge Gad, Ann-Sofie Jemth, Linda Pudelko, Lars Bräutigam
Table S1: The redox status of the cell correlates with sensitivity to MTH1 inhibition. Table S2: Data collection and refinement statistics. Table S3: Kinetic parameters of zfMTH1. Table S4: Primer sequences. Figure S1: BSO treatment sensitizes U2OS a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53ea07356ee8e4f686118522dfa0567f
https://doi.org/10.1158/0008-5472.22409340
https://doi.org/10.1158/0008-5472.22409340
Autor:
Jonas Nørskov Søndergaard, Christian Sommerauer, Ionut Atanasoai, Laura C Hinte, Keyi Geng, Giulia Guiducci, Lars Bräutigam, Myriam Aouadi, Lovorka Stojic, Isabel Barragan, Claudia Kutter
Publikováno v:
Gut. 71:2081-2092
ObjectiveTo better comprehend transcriptional phenotypes of cancer cells, we globally characterised RNA-binding proteins (RBPs) to identify altered RNAs, including long non-coding RNAs (lncRNAs).DesignTo unravel RBP-lncRNA interactions in cancer, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1f4d82fbf398e766ca8a7985cc3b40c
https://doi.org/10.1136/gutjnl-2021-325109
https://doi.org/10.1136/gutjnl-2021-325109
Autor:
Asimina Zisi, Dimitris C Kanellis, Simon Moussaud, Ida Karlsson, Helena Carén, Lars Bräutigam, Jiri Bartek, Mikael S Lindström
Publikováno v:
Neuro-Oncology.
Background High-grade gliomas are malignant brain tumors characterized by aggressiveness and resistance to chemotherapy. Prognosis remains dismal, highlighting the need to identify novel molecular dependencies and targets. Ribosome biogenesis (RiBi),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1663f86ddab96511daabdfe4a2f7b56e
https://doi.org/10.1093/neuonc/noac286
https://doi.org/10.1093/neuonc/noac286
Autor:
Xuexin Li, Maria Häggblad, Lars Bräutigam, Jordi Carreras-Puigvert, Daniela Hühn, Oscar Fernandez-Capetillo
Publikováno v:
I: Experimental therapeutics – preclinical.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66de6fa1c162d55ff5e35e6e721d962b
https://doi.org/10.1136/jnnp-2022-ehdn.237
https://doi.org/10.1136/jnnp-2022-ehdn.237
Autor:
Indre Piragyte, Zoltán M. Varga, Patrick Neuhaus, Theodora J. Stewart, Joana F. Monteiro, Rodolfo Vázquez, Ruslan Hlushchuk, Nadia Mercader, Lars Bräutigam, Adrien Mestrot, Nadine Borel, Lorenz Gfeller, David Lains, Peter Aleström, Eduardo Diaz, Xavier Langa, Ana C. Certal, Moritz Bigalke
Publikováno v:
Zebrafish
Zebrafish, 18 (4), 252–264
Zebrafish, 18 (4), 252–264
Metals and metalloids are integral to biological processes and play key roles in physiology and metabolism.Nonetheless, overexposure to some metals or lack of others can lead to serious health consequences. In this study,eight zebrafish facilities co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2317009e7adba3dcb1665160abc2e7ba
https://doi.org/10.1089/zeb.2020.1970
https://doi.org/10.1089/zeb.2020.1970
Publikováno v:
Redox Biology, Vol 2, Iss C, Pp 673-678 (2014)
Glutaredoxin 2 is a vertebrate specific oxidoreductase of the thioredoxin family of proteins modulating the intracellular thiol pool. Thereby, glutaredoxin 2 is important for specific redox signaling and regulates embryonic development of brain and v
Externí odkaz:
https://doaj.org/article/c4b85886c6c64e95bede9e25e88eb8c2