Zobrazeno 1 - 10
of 206
pro vyhledávání: '"Lars, Björck"'
Autor:
Wael Bahnan, Lotta Happonen, Hamed Khakzad, Vibha Kumra Ahnlide, Therese de Neergaard, Sebastian Wrighton, Oscar André, Eleni Bratanis, Di Tang, Thomas Hellmark, Lars Björck, Oonagh Shannon, Lars Malmström, Johan Malmström, Pontus Nordenfelt
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 2, Pp 1-21 (2022)
Abstract Group A streptococci have evolved multiple strategies to evade human antibodies, making it challenging to create effective vaccines or antibody treatments. Here, we have generated antibodies derived from the memory B cells of an individual w
Externí odkaz:
https://doaj.org/article/2bcb7da2abe14c5fb5c5a0341f1349d2
Autor:
Lotta Happonen, Simon Hauri, Gabriel Svensson Birkedal, Christofer Karlsson, Therese de Neergaard, Hamed Khakzad, Pontus Nordenfelt, Mats Wikström, Magdalena Wisniewska, Lars Björck, Lars Malmström, Johan Malmström
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Characterizing host-pathogen protein interactions can help elucidate the molecular basis of bacterial infections. Here, the authors use an integrative proteomics approach to generate a quantitative map of protein interactions between Streptococcus py
Externí odkaz:
https://doaj.org/article/5e6b3b9bfaf4481895310369f23b17c5
Autor:
Ariane Neumann, Lotta Happonen, Christofer Karlsson, Wael Bahnan, Inga-Maria Frick, Lars Björck
Publikováno v:
iScience, Vol 24, Iss 4, Pp 102339- (2021)
Summary: Streptococcus pyogenes is a major bacterial pathogen in the human population and isolates of the clinically important M1 serotype secrete protein Streptococcal inhibitor of complement (SIC) known to interfere with human innate immunity. Here
Externí odkaz:
https://doaj.org/article/d4fc296968c94f3d8fac5b22f2bc88aa
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
The Gram-positive anaerobic commensal Finegoldia magna colonizes the skin and other non-sterile body surfaces, and is an important opportunistic pathogen. Here we analyzed the effect of F. magna on human primary neutrophils. F. magna strains ALB8 (ex
Externí odkaz:
https://doaj.org/article/2532d1a85b3b47da9fd120d8b1a383e8
Autor:
Mårten Segelmark, Lars Björck
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
In primary systemic small vessel vasculitis autoantibodies are common and seem to play an important role in the pathogenesis. Autoantibodies in vasculitis are preferentially directed against components of the immune system or directly against compone
Externí odkaz:
https://doaj.org/article/bcad5a1dcfdf42d49726aeeae6cd379c
Autor:
David Ermert, Maisem Laabei, Antonin Weckel, Matthias Mörgelin, Martin Lundqvist, Lars Björck, Sanjay Ram, Sara Linse, Anna M. Blom
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Streptococcus pyogenes infects over 700 million people worldwide annually. Immune evasion strategies employed by the bacteria include binding of the complement inhibitors, C4b-binding protein (C4BP) and Factor H in a human-specific manner. We recentl
Externí odkaz:
https://doaj.org/article/c02e4610e4484bf3985548a3662a6c89
Autor:
Johannes Westman, Bhavya Chakrakodi, Johanna Snäll, Matthias Mörgelin, Martin Bruun Madsen, Ole Hyldegaard, Ariane Neumann, Inga-Maria Frick, Anna Norrby-Teglund, Lars Björck, Heiko Herwald
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Innate immunity relies on an effective recognition of the pathogenic microorganism as well as on endogenous danger signals. While bacteria in concert with their secreted virulence factors can cause a number of inflammatory reactions, danger signals r
Externí odkaz:
https://doaj.org/article/a3bd1c01143c4bdf858a00c49c66daec
Autor:
Lena Winstedt, Sofia Järnum, Emma Andersson Nordahl, Andreas Olsson, Anna Runström, Robert Bockermann, Christofer Karlsson, Johan Malmström, Gabriella Samuelsson Palmgren, Ulf Malmqvist, Lars Björck, Christian Kjellman
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0132011 (2015)
IdeS is a streptococcal protease that cleaves IgG antibodies into F(ab’)2 and Fc fragments with a unique degree of specificity, thereby providing a novel treatment opportunity of IgG-driven autoimmune conditions and antibody mediated transplant rej
Externí odkaz:
https://doaj.org/article/6f6ac6ca824a4f8190c70a48251951d2
Publikováno v:
Journal of Thrombosis and Haemostasis
We acknowledge the commentary of Gruel et al. on our recent letter [1] and are pleased that the authors agree that IdeS may be a potential treatment option for the rare but potentially severe IgG-mediated platelet activation observed in complications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95d9e429d7be974af4b6f2224a6399c4
http://europepmc.org/articles/PMC8420481
http://europepmc.org/articles/PMC8420481
Autor:
Lars Björck, Daryl Teo, Claire E. Turner, Mark Reglinski, Inga-Maria Frick, Lionel Tan, Vaitehi Nageshwaran, Mats Wikström, Nada Reza, Lucy Lamb, Shiranee Sriskandan
Publikováno v:
Tan, L K K, Reglinski, M, Teo, D, Reza, N, Lamb, L E M, Nageshwaran, V, Turner, C E, Wikstrom, M, Frick, I M, Bjorck, L & Sriskandan, S 2021, ' Vaccine-induced, but not natural immunity, against the Streptococcal inhibitor of complement protects against invasive disease ', npj Vaccines, vol. 6, no. 1, 62 . https://doi.org/10.1038/s41541-021-00326-3
npj Vaccines, Vol 6, Iss 1, Pp 1-9 (2021)
npj Vaccines
NPJ Vaccines
npj Vaccines, Vol 6, Iss 1, Pp 1-9 (2021)
npj Vaccines
NPJ Vaccines
Highly pathogenic emm1 Streptococcus pyogenes strains secrete the multidomain Streptococcal inhibitor of complement (SIC) that binds and inactivates components of the innate immune response. We aimed to determine if naturally occurring or vaccine-ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98fb2b9236f149341fd0daf0cb3d1faf
https://doi.org/10.1038/s41541-021-00326-3
https://doi.org/10.1038/s41541-021-00326-3