Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Lars, Bärfacker"'
Autor:
Lars Bärfacker, Peter Kolkhof
Publikováno v:
The Journal of Endocrinology
The cDNA of the mineralocorticoid receptor (MR) was cloned 30 years ago, in 1987. At that time, spirolactone, the first generation of synthetic steroid-based MR antagonists (MRAs), which was identified in preclinicalin vivomodels, had already been in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c99024f843ffd7b4a7868ee5d7f3aba
https://doi.org/10.1530/joe-16-0600
https://doi.org/10.1530/joe-16-0600
Autor:
Ningshu Liu, Franziska Siegel, Lars Bärfacker, Franz von Nussbaum, Karl Ziegelbauer, Ulf Bömer, William J. Scott, Stuart Ince, Amaury Ernesto Fernandez-Montalvan, Dominik Mumberg, Kirstin Meyer, Roland Neuhaus, Martin Michels, Oliver Politz, Andrea Hägebarth
Publikováno v:
International Journal of Cancer. 140:449-459
The PI3K-AKT-mTOR signaling cascade is activated in the majority of human cancers, and its activation also plays a key role in resistance to chemo and targeted therapeutics. In particular, in both breast and prostate cancer, increased AKT pathway act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ce2c1e9fe2894b3e55ba673689a4f45
https://doi.org/10.1002/ijc.30457
https://doi.org/10.1002/ijc.30457
Autor:
Dieter Lang, Ulrich Rosentreter, Franz von Nussbaum, Heike Gielen-Haertwig, Volkhart Min-Jian Li, Michael Gerisch, Martin Bechem, Helmut Haning, Dagmar Karthaus, Leila Telan, Martina Schäfer, Lars Bärfacker, Joachim Mittendorf, Sonja Anlauf, Klemens Lustig, Adrian Tersteegen, Daniel Meibom, Jens Schamberger, Swen Allerheiligen, Fitzgerald Mary F, Stefan Schäfer, Martina Delbeck
Publikováno v:
Chemmedchem
Human neutrophil elastase (HNE) is a key protease for matrix degradation. High HNE activity is observed in inflammatory diseases. Accordingly, HNE is a potential target for the treatment of pulmonary diseases such as chronic obstructive pulmonary dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa5997ad02eca73d044c6f6987027702
https://doi.org/10.1002/cmdc.201500131
https://doi.org/10.1002/cmdc.201500131
Autor:
Oliver, Politz, Franziska, Siegel, Lars, Bärfacker, Ulf, Bömer, Andrea, Hägebarth, William J, Scott, Martin, Michels, Stuart, Ince, Roland, Neuhaus, Kirstin, Meyer, Amaury Ernesto, Fernández-Montalván, Ningshu, Liu, Franz, von Nussbaum, Dominik, Mumberg, Karl, Ziegelbauer
Publikováno v:
International journal of cancer. 140(2)
The PI3K-AKT-mTOR signaling cascade is activated in the majority of human cancers, and its activation also plays a key role in resistance to chemo and targeted therapeutics. In particular, in both breast and prostate cancer, increased AKT pathway act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4779ff9245f0f8c406ddc4715ef7e9cf
https://pubmed.ncbi.nlm.nih.gov/27699769
https://pubmed.ncbi.nlm.nih.gov/27699769
Publikováno v:
Nuclear Receptors as Drug Targets
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04d53cbe8fbdc1774235549925d195a7
https://doi.org/10.1002/9783527623297.ch13
https://doi.org/10.1002/9783527623297.ch13
Autor:
F. Josef van der Staay, Heike Heckroth, Kris Rutten, Christina Erb, Martin Hendrix, Arjan Blokland, Adrian Tersteegen, Marja Van Kampen, Dagmar Karthaus, Ulrich H. Schröder, Klaus G. Reymann, Jos Prickaerts, Jean DeVry, Lars Bärfacker
Publikováno v:
Neuropharmacology, 55(5), 908-918. Elsevier Science
The present study investigated the putative pro-cognitive effects of the novel selective PDE9 inhibitor BAY 73-6691. The effects on basal synaptic transmission and long-term potentiation (LTP) were investigated in rat hippocampal slices. Pro-cognitiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b768b65c05cc80fbbd8e988e6cb9c219
https://doi.org/10.1016/j.neuropharm.2008.07.005
https://doi.org/10.1016/j.neuropharm.2008.07.005
Autor:
Peter Kolkhof, Stefan Schäfer, Axel Kretschmer, Barbara Albrecht-Küpper, Martina Delbeck, Lars Bärfacker, Frank Eitner, Elke Hartmann, Wolfram Steinke
Publikováno v:
Journal of cardiovascular pharmacology. 64(1)
Pharmacological blockade of the mineralocorticoid receptor (MR) ameliorates end-organ damage in chronic heart failure. However, the clinical use of available steroidal MR antagonists is restricted because of concomitant hyperkalemia especially in pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f6dcfbc083f6d306051da57c649e3af
https://pubmed.ncbi.nlm.nih.gov/24621652
https://pubmed.ncbi.nlm.nih.gov/24621652
Publikováno v:
European Journal of Organic Chemistry. 2000:1131-1135
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbf3b1078da919b41ea6a9004fa37d2a
https://doi.org/10.1002/1099-0690(200004)2000:7<1131::aid-ejoc1131>3.0.co
https://doi.org/10.1002/1099-0690(200004)2000:7<1131::aid-ejoc1131>3.0.co
Autor:
Christian Buss, Beate E. Kitsos-Rzychon, Lars Bärfacker, Andreas Schmidt, Christian L. Kranemann, Rafael Roggenbuck, Thorsten Rische, Peter Eilbracht, Christoph Hollmann
Publikováno v:
Chemical Reviews. 99:3329-3366
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc1c7dbfec3c15e492d2f5b74a09eeb0
https://doi.org/10.1021/cr970413r
https://doi.org/10.1021/cr970413r
Publikováno v:
European Journal of Organic Chemistry. 1999:1907-1914
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6fbb2259676ff00e49136059b50f351f
https://doi.org/10.1002/(sici)1099-0690(199908)1999:8<1907::aid-ejoc1907>3.0.co
https://doi.org/10.1002/(sici)1099-0690(199908)1999:8<1907::aid-ejoc1907>3.0.co