Výsledky vyhledávání - "Larry Wienkers"

Elimination of tucatinib, a small molecule kinase inhibitor of HER2, is primarily governed by CYP2C8 enantioselective oxidation of gem-dimethyl

Autor: Hao Sun, Kristen A. Cardinal, Larry Wienkers, Alice Chin, Vineet Kumar, Calvin Neace, Clark Henderson, Christopher J. Endres, Ariel Topletz-Erickson, Kelly Regal, Alex Vo, Stephen C. Alley, Anthony J. Lee

Publikováno v: Cancer chemotherapy and pharmacology. 89(6)

Tucatinib, a small molecule for the treatment of metastatic HER2-positive breast cancer, was extensively metabolized in humans to multiple oxidative metabolites. To fully understand the elimination and biotransformation pathways of tucatinib, we inve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b18ec46a252316d2348fe244993f0977
https://pubmed.ncbi.nlm.nih.gov/35435471

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In Vitro/In Vivo Correlation for Drug-Drug Interactions

Autor: Jan Wahlstrom, Larry Wienkers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f763df5e775acfedbc41a0c38d0aa4de
https://doi.org/10.1007/978-3-319-68864-0_14

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Cytochrome P450 Reaction Phenotyping

Autor: Jeffrey Stevens, Larry Wienkers

Publikováno v: Drug Metabolizing Enzymes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2bc6568978a107a284c2e2ab82cc2deb
https://doi.org/10.1201/9781420028485.ch8

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Akademický článek

Elimination of tucatinib, a small molecule kinase inhibitor of HER2, is primarily governed by CYP2C8 enantioselective oxidation of gem-dimethyl.

Autor: Sun, Hao, Cardinal, Kristen A., Wienkers, Larry, Chin, Alice, Kumar, Vineet, Neace, Calvin, Henderson, Clark, Endres, Christopher J., Topletz-Erickson, Ariel, Regal, Kelly, Vo, Alex, Alley, Stephen C., Lee, Anthony J.

Publikováno v: Cancer Chemotherapy & Pharmacology; Jun2022, Vol. 89 Issue 6, p737-750, 14p

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Akademický článek

Single concentration loss of activity assay provides an improved assessment of drug–drug interaction risk compared to IC50-shift.

Autor: Wong, Simon G.¹ (AUTHOR) simon.g.wong@gmail.com, Lee, Mey¹ (AUTHOR), Wong, Bradley K.¹ (AUTHOR)

Publikováno v: Xenobiotica. Nov2016, Vol. 46 Issue 11, p953-966. 14p.

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Target-mediated metabolism and target-mediated drug disposition of the DPPIV inhibitor AMG 222.

Autor: Greene, Robert J.¹ (AUTHOR) slatter@amgen.com, Tu, Hua² (AUTHOR), Gibbs, John P.¹ (AUTHOR), Greg Slatter, J.¹ (AUTHOR)

Publikováno v: Xenobiotica. Nov2011, Vol. 41 Issue 11, p945-957. 13p.

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Best practice recommendations for the transfer of cell-based assays for the measurement of neutralizing anti-drug antibodies.

Autor: Belouski, Shelley S, Born, Danika, Jacques, Susan, Harder, Brandon, Reynhardt, Kai, Kaliyaperumal, Arunan, Gupta, Shalini

Publikováno v: Bioanalysis; Sep2016, Vol. 8 Issue 17, p1845-1857, 13p

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Population pharmacokinetics analysis of AMG 416, an allosteric activator of the calcium-sensing receptor, in subjects with secondary hyperparathyroidism receiving hemodialysis.

Autor: Chen, Ping, Melhem, Murad, Xiao, Jim, Kuchimanchi, Mita, Perez Ruixo, Juan Jose

Publikováno v: Journal of Clinical Pharmacology; Jun2015, Vol. 55 Issue 6, p620-628, 9p

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Kniha

Safety Testing of Drug Metabolites: Mist Guidance Impact on the Practice of Industrial Drug Metabolism.

Autor: Nassar, Ala F.

Publikováno v: Biotransformation & Metabolite Elucidation of Xenobiotics; 2010, p295-312, 18p

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