Výsledky vyhledávání - "Larry W. Whitehouse"

Differences in Caffeine 3-Demethylation Activity among Inbred Mouse Strains: A Comparison of HepaticCyp1a2Gene Expression between Two Inbred Strains

Autor: J.Allan Menzies, William L. Casley, Michel Girard, Larry W. Whitehouse, Lyse Larocque, Thomas W. Moon, N. Mousseau

Publikováno v: Fundamental and Applied Toxicology. 40:228-237

The 3-demethylation of caffeine can be used as an index of cytochrome P450 CYP1A2 activity in vivo. We compared the plasma levels of caffeine and the 3-demethylated metabolite, 1,7-dimethylxanthine, in six common inbred strains (A/J, P/J, BALB/cJ, C3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e99c5519d32177932d02909fa712ddb
https://doi.org/10.1006/faat.1997.2394

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Increased basal expression of hepatic Cyp1a1 and Cyp 1a2 genes in inbred mice selected for susceptibility to acetaminophen-induced hepatotoxicity

Autor: T W Moon, Larry W. Whitehouse, N Mousseau, J A Menzies, M Girard, W L Casley

Publikováno v: Pharmacogenetics. 7:283-293

Susceptibility to acetaminophen-induced hepatotoxicity was found to vary widely in an outbred colony of Swiss Webster mice. Some acetaminophen-treated male mice showed a significant elevation in serum levels of the hepatic enzyme alanine aminotransfe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3db2b89305e0dc20d993459bb6a5aa4
https://doi.org/10.1097/00008571-199708000-00003

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Cytotoxicity of unsaturated metabolites of valproic acid and protection by vitamins C and E in glutathione-depleted rat hepatocytes

Autor: Larry W. Whitehouse, Wei Tang, Frank S. Abbott, Malle Jurima-Romet, Hide S. Huang

Publikováno v: Toxicology. 112:69-85

Valproic acid (VPA) and the unsaturated metabolites, 2-ene VPA and (E)-2,(Z)-3'-diene VPA, demonstrated dose-dependent cytotoxicity in primary cultures of rat hepatocytes, as evaluated by lactate dehydrogenase (LDH) leakage. Cellular glutathione (GSH

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71e0acca4018f61f04ab8e1fa21d2a50
https://doi.org/10.1016/0300-483x(96)03352-5

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Mouse hepatic metabolites of ketoconazole: Isolation and structure elucidation

Autor: Brian A. Dawson, Larry W. Whitehouse, J. Zamecnik, A. Menzies, D.B. Black, Terry D. Cyr, A.W. By

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis. 12:1425-1441

Oxidation, cleavage and degradation of the imidazole and piperazine rings, O-dealkylation, and aromatic hydroxylation are the reported pathways of ketoconazole (KC) metabolism. Metabolites were examined in hepatic extracts from male Swiss Webster mic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7de7154632470f571a82754273bffde9
https://doi.org/10.1016/0731-7085(94)00093-x

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Cytotoxic doses of ketoconazole affect expression of a subset of hepatic genes

Autor: Xuguang Li, William L. Casley, Larry W. Whitehouse, Mary Alice Hefford, Louise Larocque, Bozena Jaentschke, Carole A LeBlanc-Westwood, Carolina Ogrodowczyk, Alexander S. Whitehead, Caroline F. Thorn, Rémy A. Aubin, J.Allan Menzies

Publikováno v: Journal of toxicology and environmental health. Part A. 70(22)

Ketoconazole is a widely prescribed antifungal drug, which has also been investigated as an anticancer therapy in both clinical and pre-clinical settings. However, severe hepatic injuries were reported to be associated with the use of ketoconazole, e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cda4e0c1681195d1e6a6765fc51e8d6
https://pubmed.ncbi.nlm.nih.gov/17966066

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Detection of residual pertussis toxin in vaccines using a modified ribosylation assay

Autor: Christopher Jones, Chun-Ting Yuen, Terry D. Cyr, Catpagavalli Canthaboo, Michael J. Corbel, Dorothy Xing, J.Alan Menzies, Larry W. Whitehouse

Publikováno v: Vaccine. 21(1-2)

Pertussis toxin (PTx) in its detoxified form is an important component of both whole cell and acellular pertussis vaccines (ACVs). For safety reasons, it is imperative to ensure that the quantity of residual PTx in vaccines does not exceed permissibl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b754e84ad048ac992bc8a5dc914f00b
https://pubmed.ncbi.nlm.nih.gov/12443661

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A quantitative analysis for the ADP-ribosylation activity of pertussis toxin: an enzymatic-HPLC coupled assay applicable to formulated whole cell and acellular pertussis vaccine products

Autor: Allan J. Menzies, Jerry Calver, Terry D. Cyr, Larry W. Whitehouse

Publikováno v: Biologicals : journal of the International Association of Biological Standardization. 29(2)

The majority of the biological effects of pertussis toxin (PT) are the result of a toxin-catalyzed transfer of an adenosine diphosphate-ribose (ADP-ribose) moiety from NAD(+)to the alpha-subunits of a subset of signal-transducing guanine-nucleotide-b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d69d1a143c0b84007506b654f01b1192
https://pubmed.ncbi.nlm.nih.gov/11580213

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Reversed-phase LC assay method for deoxycholate in influenza vaccine

Autor: Michel Girard, Larry W. Whitehouse, Gnanaprakasam Solomonraj, J.Allan Menzies, Kim Hannah

Publikováno v: Journal of pharmaceutical and biomedical analysis. 12(6)

Sodium deoxycholate is used for the disruption of particles in the manufacturing of some influenza vaccines. Residual deoxycholate in inactivated vaccines is currently determined using a labour-intensive colorimetric method which lacks complete speci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b82b81045ff345a84e4324754fba8e63
https://pubmed.ncbi.nlm.nih.gov/7918786

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