Prognostic and Predictive Biomarkers in Patients With Coronavirus Disease 2019 Treated With Tocilizumab in a Randomized Controlled Trial

Autor: Fang Cai, Ivan O. Rosas, Jordi Carratalà, David Summers, Jennifer Tom, Celia J F Lin, Paolo Bonfanti, Jacqueline McBride, Bruno François, William Stubbings, Montserrat Carrasco-Triguero, Charles Edouard Luyt, Kevin G. Blyth, Cor H van der Leest, Farrah Kheradmand, Lothar Wiese, Nidhi Rohatgi, Carrie M. Rosenberger, Larry W. Tsai, Thomas Benfield, Min Bao, Aditi Qamra, Derrick Haslem

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
Tom, J, Bao, M, Tsai, L, Qamra, A, Summers, D, Carrasco-Triguero, M, McBride, J, Rosenberger, C M, Lin, C J F, Stubbings, W, Blyth, K G, Carratalà, J, François, B, Benfield, T, Haslem, D, Bonfanti, P, Van Der Leest, C H, Rohatgi, N, Wiese, L, Luyt, C E, Kheradmand, F, Rosas, I O & Cai, F 2022, ' Prognostic and Predictive Biomarkers in Patients with Coronavirus Disease 2019 Treated with Tocilizumab in a Randomized Controlled Trial∗ ', Critical Care Medicine, vol. 50, no. 3, pp. 398-409 . https://doi.org/10.1097/CCM.0000000000005229

OBJECTIVES: To explore candidate prognostic and predictive biomarkers identified in retrospective observational studies (interleukin-6, C-reactive protein, lactate dehydrogenase, ferritin, lymphocytes, monocytes, neutrophils, d-dimer, and platelets)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1872c1823bbfe8125846990b1bcf7008
http://hdl.handle.net/2445/184279

2264. An Evaluation of Empiric Treatment Patterns for Adult Patients with Community-Onset (CO) 'Low-Risk' (LR) Complicated Intra-Abdominal Infections (cIAI) Across US Hospitals

Autor: Thomas P. Lodise, Larry W. Tsai, Melanie Olesky, Kenneth Lawrence, Sergey Izmailyan

Publikováno v: Open Forum Infectious Diseases

Background Current cIAI guidelines recommend that broad-spectrum antibiotics (abs) like anti-pseudomonal β-lactams should be reserved for “high-risk” CO cIAI patients. Fluoroquinolone (FQ) use is also discouraged in geographic areas with a high

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2cf0cb77eef51b77abbf8e054509ba5
http://europepmc.org/articles/PMC6810828

Matrix modulation of compensatory lung regrowth and progenitor cell proliferation in mice

Autor: Adrian Shifren, Edward P. Ingenito, Melissa R. Mazan, Robert P. Mecham, R.A. Pierce, Larry W. Tsai, Alisha M. Gruntman, Kara M. Lascola, Carla F. Kim, R. D. Nolen-Walston, Andrew M. Hoffman

Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology. 298:L158-L168

Mechanical stress is an important modulator of lung morphogenesis, postnatal lung development, and compensatory lung regrowth. The effect of mechanical stress on stem or progenitor cells is unclear. We examined whether proliferative responses of epit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::399117f167ba0a4669128417648d85ee
https://doi.org/10.1152/ajplung.90594.2008

Epithelial Cell Apoptosis Causes Acute Lung Injury Masquerading as Emphysema

Autor: Eduardo E. Egea, Matthew J. Brown, Shane M. Hanlon, A. McGarry Houghton, Larry W. Tsai, Majd Mouded, Edward P. Ingenito, Steven D. Shapiro

Publikováno v: American Journal of Respiratory Cell and Molecular Biology. 41:407-414

Theories of emphysema traditionally revolved around proteolytic destruction of extracellular matrix. Models have recently been developed that show airspace enlargement with the induction of pulmonary cell apoptosis. The purpose of this study was to d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd044d9acdbb3f67573679c60638e355
https://doi.org/10.1165/rcmb.2008-0137oc

Relationship between dynamic respiratory mechanics and disease heterogeneity in sheep lavage injury*

Autor: Kenneth R. Lutchen, Brett A. Simon, Carissa L. Bellardine Black, Béla Suki, Larry W. Tsai, David W. Kaczka, Edward P. Ingenito, Andrew M. Hoffman

Publikováno v: Critical Care Medicine. 35:870-878

Objective: Acute respiratory distress syndrome and acute lung injury are characterized by heterogeneous flooding/collapse of lung tissue. An emerging concept for managing these diseases is to set mechanical ventilation so as to minimize the impact of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a506793ec2fae6db68efb1db75d7c506
https://doi.org/10.1097/01.ccm.0000257331.42485.94