Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Larry W. Mitcheltree"'
Autor:
Ernest H. Braue, Robin R. Deckert, Horace L Lumpkin, Kelly A Hanssen, Robert S Stevenson, John S. Graham, Stephen J. Dalal, Larry W. Mitcheltree, Bryce F Doxzon
Publikováno v:
Journal of Burn Care & Research. 28:275-285
Before sulfur mustard (HD) injuries can be effectively treated, assessment of lesion depth must occur. Accurate depth assessment is important because it dictates how aggressive treatment needs to be to minimize or prevent cosmetic and functional defi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9096b12f609d4004e97c900c244ab38
https://doi.org/10.1097/bcr.0b013e318031a1a8
https://doi.org/10.1097/bcr.0b013e318031a1a8
Autor:
Larry W. Mitcheltree, Robert P. Casillas, M. Y. Gazaway, Michael C. Babin, Karen M. Ricketts, J. P. Skvorak
Publikováno v:
Journal of Applied Toxicology. 20:S141-S144
The mouse ear vesicant model (MEVM) provides a quantitative edema response as well as histopathological and biochemical endpoints as measurements of inflammation and tissue damage following exposure to the chemical warfare agent sulfur mustard (HD).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f98349686a200a998264c511a831f5b
https://doi.org/10.1002/1099-1263(200012)20:1+<::aid-jat666>3.0.co
https://doi.org/10.1002/1099-1263(200012)20:1+<::aid-jat666>3.0.co
Autor:
James A. Blank, Robert P. Casillas, Larry W. Mitcheltree, Al W. Singer, Karen M. Ricketts, Jean A. Truxall, Robyn C. Kiser, Nancy A. Niemuth, Lilia R. Castrejon, Shawn M. Shumaker
Publikováno v:
Journal of Applied Toxicology. 20:S145-S151
The mouse ear edema model is recognized for its usefulness in studying skin responses and damage following exposure to chemical irritants, and for evaluating pharmacological agents against chemically induced skin injury. We recently modified the mous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::083e27d2a3f91e8370eb962e26da1746
https://doi.org/10.1002/1099-1263(200012)20:1+<::aid-jat665>3.0.co
https://doi.org/10.1002/1099-1263(200012)20:1+<::aid-jat665>3.0.co
Autor:
John S. Graham, Larry W. Mitcheltree, Thomas P. Logan, C. R. Nalls, John E. Zallnick, Robyn B. Lee, Jamie L. Martin, Ernest H. Braue
Publikováno v:
Skin Research and Technology. 5:56-67
Background/aims: The euthymic hairless guinea pig was the animal model of choice at this laboratory for vesicant injury research. The supply of these animals, however, was interrupted in 1993 by an outbreak of Lisferia monocyfogenes at the commercial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38361388cb1bb9de54a8f9709199ea90
https://doi.org/10.1111/j.1600-0846.1999.tb00206.x
https://doi.org/10.1111/j.1600-0846.1999.tb00206.x
Publikováno v:
Toxicology Methods. 7:381-397
The mouse ear inflammation model was used to establish simple endpoints of skin injury following cutaneous exposure to sulfur mustard (bis(2- chloroethyl)sulfide, HD). Mouse ear edema and histopathologic response to a single topical application of 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::750f97eb2a6fd9860662eb0d1e1b9a42
https://doi.org/10.1080/105172397243123
https://doi.org/10.1080/105172397243123
Publikováno v:
Journal of Applied Toxicology. 15:133-138
Erythema is the initial symptom that occurs after sulfur mustard (HD) cutaneous exposure. The time course of HD-induced erythema is similar to that observed after UV irradiation, which can be reduced by indomethacin. Sulfur mustard lethality is decre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e84008458556159552f7d0faf85654e
https://doi.org/10.1002/jat.2550150213
https://doi.org/10.1002/jat.2550150213
Autor:
Mary E. Craig, Jeffrey S. Dawson, Jeffrey J. Yourick, Larry W. Mitcheltree, Cynthia D. Benton
Publikováno v:
Toxicology. 84:185-197
Developing skin lesions on hairless guinea pigs due to 2,2'-dichlorodiethyl sulfide (sulfur mustard, HD) exposure were examined to determine the time course for the appearance of histopathologic markers in relationship to skin NAD+ and NADP+ content
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c8df90aba591f16d2945469ee63edf8
https://doi.org/10.1016/0300-483x(93)90116-a
https://doi.org/10.1016/0300-483x(93)90116-a
Autor:
Mark B. Gold, Susan L. Byers, Daniel Brobst, Daniel F. Merz, Larry W. Mitcheltree, Dana R. Anderson
Publikováno v:
Toxicology mechanisms and methods. 12(1)
Sulfur mustard (HD) is a vesicant compound that was first used as a chemical warfare agent in World War I. (Papirmeister et al. 1991). Numerous animal models have been used to study HD-induced vesication. In this article, we describe modifications of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f3d49e16403525bcd37c85560efc1d6
https://pubmed.ncbi.nlm.nih.gov/20597816
https://pubmed.ncbi.nlm.nih.gov/20597816
Publikováno v:
A50. PATHOPHYSIOLOGY OF OCCUPATIONAL AND ENVIRONMENTAL TOXIC EXPOSURES.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43422dfb0ab15cf01d6d92d15cb9f5bb
https://doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a1749
https://doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a1749
Publikováno v:
Toxicology and Applied Pharmacology. 117:104-109
It has been postulated that sulfur mustard (HD) damage may activate poly(ADP-ribose) polymerase (PADPRP), resulting in depletion of cellular NAD+. This biochemical alteration is postulated to result in blister (vesicle) formation. It has been previou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d42e97d5d4001277448a6b327a8d67f6
https://doi.org/10.1016/0041-008x(92)90223-f
https://doi.org/10.1016/0041-008x(92)90223-f