Zobrazeno 1 - 10
of 177
pro vyhledávání: '"Larry W. McLaughlin"'
Publikováno v:
PLoS ONE, Vol 4, Iss 3, p e4949 (2009)
BACKGROUND:Glycerol nucleic acid (GNA) has an acyclic phosphoglycerol backbone repeat-unit, but forms stable duplexes based on Watson-Crick base-pairing. Because of its structural simplicity, GNA is of particular interest with respect to the possibil
Externí odkaz:
https://doaj.org/article/d23b0324c7dd4d6f8f217d3f00ff5598
Publikováno v:
Chemical Communications. 52:11905-11907
The significance of the precise position of the hydroxyl at the 3'-end of an RNA primer for nonenzymatic template-directed primer extension is not well understood. We show that an RNA primer terminating in 3'-hydroxymethyl-2',3'-dideoxy-guanosine has
Autor:
Charles C. Richardson, Larry W. McLaughlin, Sabine R. Akabayov, Antoine M. van Oijen, Christopher S. Theile, Arkadiusz W. Kulczyk, B B Beauchamp, Barak Akabayov
Publikováno v:
The Journal of Biological Chemistry, 286(33), 29146-29157. AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DNA polymerases catalyze the 3'-5'-pyrophosphorolysis of a DNA primer annealed to a DNA template in the presence of pyrophosphate (PP(i)). In this reversal of the polymerization reaction, deoxynucleotides in DNA are converted to deoxynucleoside 5'-tr
Autor:
Larry W. McLaughlin, Zhenhua Sun
Publikováno v:
Biopolymers. 87:183-195
DNA sequences containing four types of analog nucleosides are described. All four are pyridine derivatives constructed as C-nucleosides so that they mimic the pyrimidine derivatives 2′-deoxyuridine, thymidine or 2′-deoxycytidine, but in all cases
Publikováno v:
The Journal of Organic Chemistry. 71:2922-2925
The syntheses of four pyrimidine C-nucleosides are described. These derivatives are designed as mimics of dC and dU, and in that respect, each can form two hydrogen bonds with complementary dG or dA residues. The minor groove O2 carbonyl in each deri
Autor:
John C. Chaput, Larry W. McLaughlin, Allen Horhota, Jack W. Szostak, Keyong Zou, Biao Yu, Justin K. Ichida
Publikováno v:
Journal of the American Chemical Society, vol 127, iss 20
Journal of the American Chemical Society
Journal of the American Chemical Society
alpha-l-Threofuranosyl nucleoside triphosphates (tNTPs) are tetrafuranose nucleoside derivatives and potential progenitors of present-day beta-d-2'-deoxyribofuranosyl nucleoside triphosphates (dNTPs). Therminator DNA polymerase, a variant of the 9 de
Publikováno v:
Angewandte Chemie. 116:5932-5935
Publikováno v:
Nucleic Acids Research. 31:1536-1540
Here we describe the crystal structure of modified [d(CGCGAATTCGCG)]2 refined to 2.04 A ˚ . The modification, which affects only the two thymines at the central ApT step, involves isosteric removal of the 2-keto oxygen atoms and substitution of the
Publikováno v:
Nucleic Acids Research. 28:3316-3322
Two analog uridine triphosphates tethering additional functionality, one a primary amino group and the second a mercapto group, were prepared and tested for their compatibility with in vitro RNA selection procedures. 5-(3-Aminopropyl)uridine triphosp
Autor:
Duncan T. Odom, Megan E. Núñez, Larry W. McLaughlin, David A. Vicic, Jacqueline K. Barton, Diego A. Gianolio
Publikováno v:
Journal of the American Chemical Society. 122:8603-8611
A thymine cyclobutane dimer, site-specifically incorporated in a DNA duplex, is shown to be repaired upon photoexcitation (at 380 nm) of a naphthalene diimide intercalator (NDI), either bound noncovalently to the duplex or covalently appended to the