Zobrazeno 1 - 10
of 430
pro vyhledávání: '"Larry W. Kwak"'
Autor:
Szymon J. Szymura, Lin Wang, Tiantian Zhang, Soung-chul Cha, Joo Song, Zhenyuan Dong, Aaron Anderson, Elizabeth Oh, Vincent Lee, Zhe Wang, Sapna Parshottam, Sheetal Rao, Jasper B. Olsem, Brandon N. Crumpton, Hans C. Lee, Elisabet E. Manasanch, Sattva Neelapu, Larry W. Kwak, Sheeba K. Thomas
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Lymphoplasmacytic lymphoma (LPL) is an incurable low-grade lymphoma with no standard therapy. Nine asymptomatic patients treated with a first-in-human, neoantigen DNA vaccine experienced no dose limiting toxicities (primary endpoint, NCT0120
Externí odkaz:
https://doaj.org/article/b4cc18ce434b4c7584d647c8e9b7b29b
Autor:
James Godfrey, Matthew Mei, Lu Chen, Joo Y. Song, Victoria Bedell, Elizabeth Budde, Saro Armenian, Sandrine Puverel, Liana Nikolaenko, Robert Chen, Shari Daniels, Neena Kennedy, Lacolle Peters, Steven T. Rosen, Stephen J. Forman, Leslie L. Popplewell, Larry W. Kwak, Alex F. Herrera
Publikováno v:
Haematologica, Vol 109, Iss 2 (2023)
Outcomes after programmed death-1 (PD-1) blockade in B-cell lymphomas are disappointing with few durable responses. Histone deacetylase inhibitors exhibit favorable immunomodulatory effects and demonstrate synergistic anti-tumor immune responses with
Externí odkaz:
https://doaj.org/article/ca13d2b46a794156a04e53d9d477b58f
Autor:
Robert W. Chen, Joycelynne M. Palmer, Sarah Tomassetti, Leslie L. Popplewell, Jessica Alluin, Pritsana Chomchan, Auayporn P. Nademanee, Tanya Siddiqi, Ni-Chun Tsai, Lu Chen, Fay Zuo, Rosemarie Abary, Ji-lian Cai, Alex F. Herrera, John J. Rossi, Steven T. Rosen, Stephen J. Forman, Larry W. Kwak, Leona A. Holmberg
Publikováno v:
Journal of Hematology & Oncology, Vol 11, Iss 1, Pp 1-7 (2018)
Abstract Background Mantle cell lymphoma (MCL) is an aggressive and incurable lymphoma. Standard of care for younger patients with MCL is induction chemotherapy followed by autologous stem cell transplantation (auto-HCT). Rituximab maintenance after
Externí odkaz:
https://doaj.org/article/2c3564466ed04bbbb46e3c36e69657ed
Autor:
Sheeba K. Thomas, Soung-chul Cha, D. Lynne Smith, Kun Hwa Kim, Sapna R. Parshottam, Sheetal Rao, Michael Popescu, Vincent Y. Lee, Sattva S. Neelapu, Larry W. Kwak
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-9 (2018)
Abstract Background There is now a renewed interest in cancer vaccines. Patients responding to immune checkpoint blockade usually bear tumors that are heavily infiltrated by T cells and express a high load of neoantigens, indicating that the immune s
Externí odkaz:
https://doaj.org/article/9222e7054e594b22954ccc078ebdb33c
Autor:
Cara Haymaker, Yi Yang, Junmei Wang, Qiang Zou, Anupama Sahoo, Andrei Alekseev, Divyendu Singh, Krit Ritthipichai, Yared Hailemichael, Oanh N. Hoang, Hong Qin, Kimberly S. Schluns, Tiejun Wang, Willem W. Overwijk, Shao-Cong Sun, Chantale Bernatchez, Larry W. Kwak, Sattva S. Neelapu, Roza Nurieva
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Grail is an E3 ubiquitin ligase that inhibits T-cell receptor signalling in CD4+ T cells. Here the authors show Grail also limits IL-21 receptor expression and function in CD8+ T cells, is overactive in these cells in patients with lymphoma, and prom
Externí odkaz:
https://doaj.org/article/4450d2168a5641f593a18e67e984d580
Autor:
Justin Kline, Ronald Levy, Joshua Brody, James N. Kochenderfer, Edmund K. Waller, Sundar Jagannath, Michael R. Bishop, David Siegel, David Avigan, Michael Boyiadzis, Jeffrey Miller, Rafat Abonour, Kenneth C. Anderson, Stephen M. Ansell, Lisa Barbarotta, Austin John Barrett, Koen Van Besien, P. Leif Bergsagel, Ivan Borrello, Jill Brufsky, Mitchell Cairo, Ajai Chari, Adam Cohen, Jorge Cortes, Stephen J. Forman, Jonathan W. Friedberg, Ephraim J. Fuchs, Steven D. Gore, Brad S. Kahl, Larry W. Kwak, Marcos de Lima, Mark R. Litzow, Anuj Mahindra, Nikhil C. Munshi, Robert Z. Orlowski, John M. Pagel, David L. Porter, Stephen J. Russell, Karl Schwartz, Margaret A. Shipp, Richard M. Stone, Martin S. Tallman, John M. Timmerman, Frits Van Rhee, Ann Welsh, Michael Werner, Peter H. Wiernik, Madhav V. Dhodapkar
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 4, Iss 1 (2016)
Increasing knowledge concerning the biology of hematologic malignancies as well as the role of the immune system in the control of these diseases has led to the development and approval of immunotherapies that are resulting in impressive clinical res
Externí odkaz:
https://doaj.org/article/058020890a704e00a7da52df34f259b6
Autor:
Lijuan Wang, Jianfei Qian, Yong Lu, Haiyan Li, Hanying Bao, Donghua He, Zhiqiang Liu, Yuhuan Zheng, Jin He, Yi Li, Sattva Neelapu, Jing Yang, Larry W. Kwak, Qing Yi, Zhen Cai
Publikováno v:
Haematologica, Vol 98, Iss 9 (2013)
Clinical trials of immunotherapy in mantle cell lymphoma have not yet delivered desirable results, partly because of the inhibitory machinery of the tumor and its microenvironment. Here we investigated the role of B7-H1, a member of the B7 family of
Externí odkaz:
https://doaj.org/article/57934593b94b47fcac0c32d82ea07843
Autor:
Weixin Wang, Meghan Corrigan-Cummins, Justin Hudson, Irina Maric, Olga Simakova, Sattva S. Neelapu, Larry W. Kwak, John E. Janik, Barry Gause, Elaine S. Jaffe, Katherine R. Calvo
Publikováno v:
Haematologica, Vol 97, Iss 4 (2012)
Background MicroRNAs can play an important role in tumorigenesis through post-transcriptional regulation of gene expression, and are not well characterized in follicular lymphoma.Design and Methods MicroRNA profiles of enriched follicular lymphoma tu
Externí odkaz:
https://doaj.org/article/9d56f0d8745d44dc992f50697bb5b6c1
Publikováno v:
Haematologica, Vol 92, Iss 2 (2007)
B-lymphocyte stimulator (BLyS) plays a critical role in the survival of B-lymphocytes. In 50 patients with Hodgkin’s lymphoma BLyS levels were higher in newly diagnosed patients (median 2.0 ng/mL, range
Externí odkaz:
https://doaj.org/article/e15f0fc7ba304c01bd19cd81a756efc6
Autor:
Alex F Herrera, Lu Chen, Yago Nieto, Leona Holmberg, Patrick Johnston, Matthew Mei, Leslie Popplewell, Saro Armenian, Thai Cao, Leonardo Farol, Firoozeh Sahebi, Ricardo Spielberger, Robert Chen, Auayporn Nademanee, Sandrine Puverel, Mary Nwangwu, Peter Lee, Joo Song, Alan Skarbnik, Neena Kennedy, Lacolle Peters, Steven T Rosen, Larry W Kwak, Stephen J Forman, Tatyana Feldman
Publikováno v:
The Lancet Haematology. 10:e14-e23