Zobrazeno 1 - 10
of 137
pro vyhledávání: '"Larry W. Jenkins"'
Autor:
C. Edward Dixon, Valerian E. Kagan, David V. Ritzel, Robert H. Garman, Patrick M. Kochanek, Hong Q. Yan, Geoffrey S.F. Ling, David Shellington, Richard A. Bauman, Larry W. Jenkins, Samuel S. Shin, Edwin K. Jackson, Robert S. B. Clark, Faris A. Bandak, Hülya Bayır, Peter V. Swauger, Steven Parks
Publikováno v:
Journal of Neurotrauma. 30:920-937
Explosive blast-induced traumatic brain injury (TBI) is the signature insult in modern combat casualty care and has been linked to post-traumatic stress disorder, memory loss, and chronic traumatic encephalopathy. In this article we report on blast-i
Autor:
Lesley M. Foley, Patrick M. Kochanek, Stephen R. Wisniewski, Chien Ho, John A. Melick, Larry W. Jenkins, Alia M Iqbal O'Meara, T. Kevin Hitchens
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 33:129-136
Secondary insults such as hypotension or hemorrhagic shock (HS) can greatly worsen outcome after traumatic brain injury (TBI). We recently developed a mouse combined injury model of TBI and HS using a controlled cortical impact (CCI) model and showed
Autor:
Patrick M. Kochanek, Samuel A. Tisherman, Joseph N. Hemerka, Vincent Vagni, Xianren Wu, Larry W. Jenkins, Brian Blasiole, David Shellington, Robert H. Garman, Jennifer L. Exo, Hülya Bayır, Mu Xu, C. Edward Dixon, Keri Janesko-Feldman, Robert S. B. Clark, Stephen R. Wisniewski
Publikováno v:
Journal of Neurotrauma. 29:2192-2208
Hypotension after traumatic brain injury (TBI) worsens outcome. We published the first report of TBI plus hemorrhagic shock (HS) in mice using a volume-controlled approach and noted increased neuronal death. To rigorously control blood pressure durin
Autor:
Edwin K. Jackson, Patrick M. Kochanek, Richard A. Bauman, David V. Ritzel, Hülya Bayır, Steven Parks, Robert S. B. Clark, Peter V. Swauger, Valerian E. Kagan, Lawrence C. Tong, Larry W. Jenkins, Robert C. Switzer, Robert H. Garman, C. Edward Dixon
Publikováno v:
Journal of Neurotrauma. 28:947-959
Blast-induced traumatic brain injury (TBI) is the signature insult in combat casualty care. Survival with neurological damage from otherwise lethal blast exposures has become possible with body armor use. We characterized the neuropathologic alterati
Autor:
Jennifer L. Exo, David Shellington, Larry W. Jenkins, Carleton J. C. Hsia, Xianren Wu, Li Ma, Patrick M. Kochanek, Hülya Bayır, Lina Du, Vincent Vagni, C. Edward Dixon, Keri Janesko-Feldman, Robert S. B. Clark
Publikováno v:
Critical Care Medicine. 39:494-505
Resuscitation of hemorrhagic hypotension after traumatic brain injury is challenging. A hemoglobin-based oxygen carrier may offer advantages. The novel therapeutic hemoglobin-based oxygen carrier, polynitroxylated pegylated hemoglobin (PNPH), may rep
Autor:
Edwin K. Jackson, Dongmei Cheng, M. Lee Haselkorn, Delbert G. Gillespie, Keri Janesko-Feldman, David Shellington, Gregg E. Homanics, Jurgen Schnermann, Vincent Vagni, Michael J. Bell, Patrick M. Kochanek, Larry W. Jenkins, Raghvendra K. Dubey
Publikováno v:
Journal of Neurotrauma. 27:901-910
We reported that adenosine A(1) receptor (A(1)AR) knockout (KO) mice develop lethal status epilepticus after experimental traumatic brain injury (TBI), which is not seen in wild-type (WT) mice. Studies in epilepsy, multiple sclerosis, and neuro-oncol
Autor:
Li Ma, Larry W. Jenkins, Robert S. B. Clark, Vincent Vagni, Carleton J. C. Hsia, Patrick M. Kochanek, Jennifer L. Exo, David Shellington, Keri Janesco-Feldman, Hülya Bayır, C. Edward Dixon
Publikováno v:
Journal of Neurotrauma. 26:2403-2408
Outcome after traumatic brain injury (TBI) is worsened by hemorrhagic shock (HS), but the optimal resuscitation approach is unclear. In particular, treatment of TBI patients with colloids remains controversial. We hypothesized that resuscitation with
Autor:
Simon C. Watkins, Csaba Szabó, Larry W. Jenkins, Patrick M. Kochanek, Yi-Chen Lai, Fengli Guo, Robert S. B. Clark, Yaming Chen, Paula D. Nathaniel
Publikováno v:
Journal of Neurochemistry. 104:1700-1711
Poly-ADP-ribosylation is a post-translational modification performed by poly(ADP-ribose) polymerases (PARP), involved in many diverse cellular functions including DNA repair, transcription, and long-term potentiation. Paradoxically, PARP over-activat
Autor:
Csaba Szabó, Larry W. Jenkins, Paula D. Nathaniel, C. Edward Dixon, Robert S. B. Clark, Vincent Vagni
Publikováno v:
Journal of Neurotrauma. 24:1399-1405
Poly(ADP-ribose) polymerase-1 (PARP-1) is an enzyme best known for its role in DNA repair and as a mediator of NAD+ depletion and energy failure-induced cell death. We tested the effect of the potent and selective ideno-isoquinolone PARP-1 inhibitor
Autor:
Xianren Wu, Larry W. Jenkins, S. William Stezoski, Samuel A. Tisherman, Patrick M. Kochanek, Tomas Drabek, Robert H. Garman, Jason Stezoski, Jesse A. Fisk
Publikováno v:
Critical Care Medicine. 35:532-537
Emergency preservation and resuscitation (EPR) comprise a novel approach for resuscitation of exsanguination cardiac arrest victims. EPR uses a cold aortic flush to induce deep hypothermic preservation, followed by resuscitation with cardiopulmonary