Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Larry W, Hertel"'
1
Advances Toward new antidepressants beyond SSRIs: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 2
Autor: Kumiko, Takeuchi, Todd J, Kohn, Nicholas A, Honigschmidt, Vincent P, Rocco, Patrick G, Spinazze, Daniel J, Koch, Steven T, Atkinson, Larry W, Hertel, David L, Nelson, D Bradley, Wainscott, Laura J, Ahmad, Janice, Shaw, Penny G, Threlkeld, David T, Wong
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 13:2393-2397
Potent 5-HT1A/SSRIs at low nanomolar and subnanomolar concentrations were identified in a series of 1-(1H-indol-4-yloxy)-3-(4-benzo[b]thiophen-2-ylpiperidinyl)propan-2-ols. Incorporation of an alpha-Me group in the piperidine ring with its specific s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2415887eb761a5e60b2f6c86c07d36ec
https://doi.org/10.1016/s0960-894x(03)00392-5
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2
Comparison of the Inhibition of Type A and Type BS-Adenosylhomocysteine Hydrolase: Effects of Cofactor Content on Inhibition Behavior and Nucleoside Binding
Autor: Angelika Muscate, Larry W. Hertel, Ronald J. Parry
Publikováno v: Journal of Enzyme Inhibition. 8:243-253
The enzyme S-adenosylhomocysteine hydrolase (E.C.3.3.1.1) occurs in two forms in bovine liver: Type A, which carries four moles of NAD+ per mole of enzyme tetramer, and Type B, which carries two moles of NAD+ per mole of tetramer.1 The inhibition of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65fc05f3a7997ac8af2f34ca933a6b94
https://doi.org/10.3109/14756369509020131
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3
Advances toward new antidepressants beyond SSRIs: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 3
Autor: Kumiko Takeuchi, Todd J Kohn, Nicholas A Honigschmidt, Vincent P Rocco, Patrick G Spinazze, Steven T Atkinson, Larry W Hertel, David L Nelson, D.Bradley Wainscott, Laura J Ahmad, Janice Shaw, Penny G Threlkeld, David T Wong
Publikováno v: Bioorganicmedicinal chemistry letters. 13(22)
A series of 1-aryloxy-3-piperidinylpropan-2-ols possessing potent dual 5-HT(1A) receptor antagonism and serotonin reuptake inhibition was discovered. Modification of potential metabolic sites of 1-(1H-indol-4-yloxy)-3-(4-benzo[b]thiophen-2-ylpiperidi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::470085d4b8c94794f86762633f5876c1
https://pubmed.ncbi.nlm.nih.gov/14592479
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4
Radiosensitization of pancreatic cancer cells by 2',2'-difluoro-2'-deoxycytidine
Autor: Larry W. Hertel, Theodore S. Lawrence, Tina M. Hahn, Donna S. Shewach, Emily Y. Chang
Publikováno v: International journal of radiation oncology, biology, physics. 34(4)
Purpose We have reported that the deoxycytidine analog 2',2'difluoro-2'-deoxycytidine (dFdCyd) is a potent radiosensitizer of HT29 human colon cancer cells probably through its effects on intracellular deoxyribonucleotide (dNTP) pools. Because dFdCyd
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29d0424895485bd3d7c2d9c61f56d489
https://pubmed.ncbi.nlm.nih.gov/8598364
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8
Electronic control of stereoselectivity. 1. Singlet oxygen and related electrophilic additions to aryl-substituted 7-isopropylidenebenzonorbornenes
Autor: Michael C. Boehm, Rolf Gleiter, Leo A. Paquette, Larry W. Hertel
Publikováno v: Journal of the American Chemical Society. 100:6510-6512
Bei Photooxidationen der Isopropylidennorbornene (I) bestimmen wahrscheinlich hauptsachlich zwei Mechanismen das anti:syn-Verhaltnis im Produktgemisch.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::afd401482c612bb519d67accc370238d
https://doi.org/10.1021/ja00488a046
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