Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Larry V. Hryshko"'
Autor:
Ian M.C. Dixon, James A. Thliveris, Rakesh C. Arora, Ganghong Tian, Larry V. Hryshko, Emma Avery, Jaskiran Sandha, Darren H. Freed, Christopher W. White, Jayan Nagendran, A. Müller
Publikováno v:
The Annals of Thoracic Surgery. 105:1763-1770
Background Normothermic ex vivo heart perfusion (EVHP) has been shown to improve the preservation of hearts donated after circulatory arrest and to facilitate clinical successful transplantation. Steroids are added to the perfusate solution in curren
Autor:
Devin Hasanally, Christopher W. White, Ganghong Tian, Ryan Lillico, Stephen R. Large, Jayan Nagendran, Ian M.C. Dixon, Larry V. Hryshko, E. Ambrose, Darren H. Freed, Keith J. Simons, T.W. Lee, Fei Wang, Bo Xiang, Ayyaz Ali, A. Müller, Ted M. Lakowski, Rakesh C. Arora, Simon Messer, Y. Li, Ousama Rachid, H. Le, Jaskiran Sandha
Publikováno v:
American Journal of Transplantation. 16:783-793
Hearts donated following circulatory death (DCD) may represent an additional source of organs for transplantation; however, the impact of donor extubation on the DCD heart has not been well characterized. We sought to describe the physiologic changes
Autor:
T.W. Lee, Ian M.C. Dixon, Larry V. Hryshko, Jayan Nagendran, James A. Thliveris, A. Müller, Ganghong Tian, Darren H. Freed, Y. Li, Christopher W. White, E. Ambrose, Rakesh C. Arora, H. Le
Publikováno v:
American Journal of Transplantation. 16:773-782
The resuscitation of hearts donated after circulatory death (DCD) is gaining widespread interest; however, the method of initial reperfusion (IR) that optimizes functional recovery has not been elucidated. We sought to determine the impact of IR temp
Autor:
P. Mundt, Devin Hasanally, Yun Li, Ayyaz Ali, Stephen R. Large, Larry V. Hryshko, Christopher W. White, Darren H. Freed, S. Colah, Bo Xiang, Julianne Klein, Matthew Lytwyn, Amir Ravandi, T.W. Lee, Rakesh C. Arora, Ganghong Tian
Publikováno v:
The Journal of Heart and Lung Transplantation. 32:734-743
Background Ex vivo heart perfusion (EVHP) has been proposed as a means to facilitate the resuscitation of donor hearts after cardiocirculatory death (DCD) and increase the donor pool. However, the current approach to clinical EVHP may exacerbate myoc
Modification of Ca2+-handling in cardiomyocytes by redox sensitive mechanisms in response to ouabain
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 91:45-55
We examined the role of redox-sensitive signal transduction mechanisms in modifying the changes in [Ca2+]iproduced by ouabain upon incubating adult rat cardiomyocytes with antioxidants or inhibitors of different protein kinases and monitoring alterat
Autor:
A. Müller, Hoa Le, Darren H. Freed, Ian M.C. Dixon, E. Ambrose, T.W. Lee, Yun Li, James A. Thliveris, Larry V. Hryshko, Sanaz Hatami, Christopher W. White, Jayan Nagendran, Rakesh C. Arora, Ganghong Tian
Publikováno v:
The Annals of thoracic surgery. 103(1)
Background: Hearts donated after circulatory death may represent an additional donor source. The influx of sodium and calcium ions across the sarcolemma play a central role in the pathogenesis of ischemia-reperfusion injury; however, this process may
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 90:249-260
We tested whether the activation of proteolytic enzymes, calpain, and matrix metalloproteinases (MMPs) during ischemia–reperfusion (I/R) is mediated through oxidative stress. For this purpose, isolated rat hearts were subjected to a 30 min global i
Autor:
James S. C. Gilchrist, Hoa Dinh Le, Vladimir Yurkov, Kristy D. Ranson, Danielle DeMoissac, Larry V. Hryshko, Alexander Omelchenko, Mark Hnatowich
Publikováno v:
Cell Calcium. 51:164-170
μ-Calpain is a Ca(2+)-activated protease abundant in mammalian tissues. Here, we examined the effects of μ-calpain on three alternatively spliced variants of NCX1 using the giant, excised patch technique. Membrane patches from Xenopus oocytes expre
Autor:
Yun Li, Lisa Chilton, Larry V. Hryshko, Ian M.C. Dixon, Neeraj Visen, Joshua E. Raizman, Darren H. Freed, Sunil G. Rattan, Aran L. Dangerfield
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 301:H514-H522
Chemotactic movement of myofibroblasts is recognized as a common means for their sequestration to the site of tissue injury. Following myocardial infarction (MI), recruitment of cardiac myofibroblasts to the infarct scar is a critical step in wound h
Autor:
Thane G. Maddaford, Larry V. Hryshko, Bradley P. Ander, Anton Lukas, Carla S. Raposo, Justin F. Deniset, Grant N. Pierce, Cecilia Hurtado
Publikováno v:
Cardiovascular Research. 73:395-403
Dietary intake of omega-3 polyunsaturated fatty acids (PUFA) like alpha-linolenic acid (ALA) is antiarrhythmic and cardioprotective. PUFA may also be beneficial in hypertension. Altered Na(+)-Ca(2+) exchanger (NCX) activity has been implicated in arr