Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Larry T. Pierce"'
Autor:
Louise N. Cooney, Kevin D. O’Shea, Hannah J. Winfield, Michael M. Cahill, Larry T. Pierce, Florence O. McCarthy
Publikováno v:
Pharmaceuticals, Vol 16, Iss 9, p 1191 (2023)
The evolution of bisindolyl maleimides and indolyl maleimide derivatives and their unique biological activities have stimulated great interest in medicinal chemistry programs. Bisindolylmaleimide (BIM)-type compounds arise from natural sources such a
Externí odkaz:
https://doaj.org/article/0598606e4a584275865e2453fc532b12
Autor:
Michael M. Cahill, Kevin D. O’Shea, Larry T. Pierce, Hannah J. Winfield, Kevin S. Eccles, Simon E. Lawrence, Florence O. McCarthy
Publikováno v:
Pharmaceuticals, Vol 10, Iss 3, p 62 (2017)
The synthesis and biological evaluation of a series of novel heterocyclic indole derivatives is described. The consolidation of the combretastatin and bisindolylmaleimide templates towards the inclusion of a novel heterocyclic ring proffered a versat
Externí odkaz:
https://doaj.org/article/2a83132e9ff840f9935f3a38a6a8f6bc
Autor:
Hannah J. Winfield, Michael M. Cahill, Stéphane Bach, Pascal Marchand, Florence O. McCarthy, Kevin O'Shea, Larry T. Pierce, Thomas Robert, Sandrine Ruchaud
Publikováno v:
Bioorganic and Medicinal Chemistry
Bioorganic and Medicinal Chemistry, Elsevier, 2018, 26 (14), pp.4209-4224. ⟨10.1016/j.bmc.2018.07.012⟩
Bioorganic and Medicinal Chemistry, Elsevier, 2018, 26 (14), pp.4209-4224. ⟨10.1016/j.bmc.2018.07.012⟩
Synthesis and biological evaluation of a series of novel indole derivatives as anticancer agents is described. A bisindolylmaleimide template has been derived as a versatile pharmacophore with which to pursue chemical diversification. Starting from m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20cae57756dd1350b1dff948c3e82173
https://doi.org/10.1016/j.bmc.2018.07.012
https://doi.org/10.1016/j.bmc.2018.07.012
Publikováno v:
Proceedings of 4th International Electronic Conference on Medicinal Chemistry.
The 3,4,5-trimethoxyphenyl moiety is a common motif employed in anticancer drug discovery, due to its prevalence in a variety of important natural products such as Combretastatin. Work undertaken by our group and others has demonstrated that structur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5be7bedc25717016d1ad2846e5adae46
https://doi.org/10.3390/ecmc-4-05640
https://doi.org/10.3390/ecmc-4-05640
Autor:
Larry T. Pierce, Florence O. McCarthy, Simon E. Lawrence, Kevin O'Shea, Kevin S. Eccles, Michael M. Cahill, Hannah J. Winfield
Publikováno v:
Pharmaceuticals
Pharmaceuticals; Volume 10; Issue 3; Pages: 62
Pharmaceuticals, Vol 10, Iss 3, p 62 (2017)
Pharmaceuticals; Volume 10; Issue 3; Pages: 62
Pharmaceuticals, Vol 10, Iss 3, p 62 (2017)
The synthesis and biological evaluation of a series of novel heterocyclic indole derivatives is described. The consolidation of the combretastatin and bisindolylmaleimide templates towards the inclusion of a novel heterocyclic ring proffered a versat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bf4c9646ee852e80d35a4b6370e580e
https://hdl.handle.net/10468/4879
https://hdl.handle.net/10468/4879
Publikováno v:
European Journal of Medicinal Chemistry. 56:292-300
A range of 5,6-bisindole and 5-indole-6-(7-azaindole)pyrimidinones were synthesised via a β-keto ester intermediate and a screen of cyclisation conditions undertaken. The optimised route to this new class of indolocarbazoles and azaindolocarbazoles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c44fcc7755bc6b9281777c5624cd6a10
https://doi.org/10.1016/j.ejmech.2012.08.002
https://doi.org/10.1016/j.ejmech.2012.08.002
Publikováno v:
Tetrahedron. 67:4601-4611
Synthesis of a diverse series of novel 3,4-diaryl-5-aminopyrazoles as candidates in the development of new protein kinase inhibitors is reported for the first time. In the course of a wider study into bisindolylmaleimide (BIM) derivatives, we examine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f55d8f94bb9299be9957187e24bba93
https://doi.org/10.1016/j.tet.2011.04.077
https://doi.org/10.1016/j.tet.2011.04.077
Publikováno v:
Tetrahedron. 66:9754-9761
2,3-Bis(1-methyl-1H-indol-3-yl) methyl-3-oxopropionate is a key intermediate in the synthesis of a new family of LY333531 analogues. Base-mediated cyclocondensation with thiourea afforded novel 5,6-bis(1-methyl-1H-indol-3-yl)-2-thioxo-2,3-dihydropyri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea56de7633b652aaeca4390c8472201f
https://doi.org/10.1016/j.tet.2010.10.020
https://doi.org/10.1016/j.tet.2010.10.020