Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Larry S. Zweifel"'
Autor:
Dipanwita Pati, Lisa R. Taxier, Mengfan Xia, Sophia I. Lee, Sara Y. Conley, Tori Sides, Kristen M. Boyt, Avery C. Hunker, Larry S. Zweifel, Thomas L. Kash
Publikováno v:
Addiction Neuroscience, Vol 11, Iss , Pp 100157- (2024)
Dysregulation of the dopamine (DA) system is a hallmark of substance use disorders, including alcohol use disorder (AUD). Of the DA receptor subtypes, the DA D2 receptors (D2Rs) play a key role in the reinforcing effects of alcohol. D2Rs are expresse
Externí odkaz:
https://doaj.org/article/bbb5fbfa91bd4021b419202c30ff7ee0
Publikováno v:
Neurobiology of Stress, Vol 23, Iss , Pp 100527- (2023)
The anterior portion of the bed nucleus of the stria terminalis (BNST) modulates fear and stress responses. The anterodorsal BNST (adBNST) can be anatomically subdivided further into the lateral and medial divisions. Although output projections of BN
Externí odkaz:
https://doaj.org/article/75adfc267425433ea0cb722091f68203
Autor:
Jian Qiu, Martha A. Bosch, Todd L. Stincic, Avery C. Hunker, Larry S. Zweifel, Oline K. Rønnekleiv, Martin J. Kelly
Publikováno v:
Molecular Metabolism, Vol 66, Iss , Pp 101645- (2022)
Objective: Proopiomelanocortin (POMC) neurons are the key anorexigenic hypothalamic neuron for integrating metabolic cues to generate the appropriate output for maintaining energy homeostasis and express the requisite channels as a perfect synaptic i
Externí odkaz:
https://doaj.org/article/6c8f4be480964addb3b17dc712cb716d
Publikováno v:
Frontiers in Neural Circuits, Vol 16 (2022)
Neuropeptides play an important role in modulating mesolimbic system function. However, while synaptic inputs to the ventral tegmental area (VTA) have been extensively mapped, the sources of many neuropeptides are not well resolved. Here, we mapped t
Externí odkaz:
https://doaj.org/article/aa4d23b01d6148d4bec9a628cfbd5fbf
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Learned conditioned fear associations can be weakened (extinction learning), but extinction is less effective if performed too soon after the original fear conditioning. Here, the authors show that persistent activation of CRF-expressing neurons in t
Externí odkaz:
https://doaj.org/article/f50f1c98dcf546afbe56dc8a475cedea
Autor:
Todd L. Stincic, Martha A. Bosch, Avery C. Hunker, Barbara Juarez, Ashley M. Connors, Larry S. Zweifel, Oline K. Rønnekleiv, Martin J. Kelly
Publikováno v:
Molecular Metabolism, Vol 49, Iss , Pp 101218- (2021)
Objective: Arcuate nucleus neuropeptide Y/agouti-related peptide (NPY/AgRP) neurons drive ingestive behavior. The M-current, a subthreshold non-inactivating potassium current, plays a critical role in regulating NPY/AgRP neuronal excitability. Fastin
Externí odkaz:
https://doaj.org/article/fb095b3020044ae88ead4c1b4cac825f
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
The role of the superior colliculus (SC) in modulating V1 cortical activity is not clear. Here, the authors demonstrate the functional role of SC in modulating V1 responses through an excitatory pathway via the dorsal lateral geniculate nucleus.
Externí odkaz:
https://doaj.org/article/502fa596fe35460dbab617293f593984
Autor:
Avery C. Hunker, Larry S. Zweifel
Publikováno v:
STAR Protocols, Vol 1, Iss 2, Pp 100070- (2020)
Summary: AAV-CRISPR/Cas9 permits gene mutagenesis in the adult CNS. Current methods determining in vivo on-target mutagenesis have been limited by the ability to isolate virally transduced cells. This protocol optimizes a workflow for the design, clo
Externí odkaz:
https://doaj.org/article/533d39031bb743c88221aa7400cfe729
Autor:
Timothy M. Locke, Hirofumi Fujita, Avery Hunker, Shelby S. Johanson, Martin Darvas, Sascha du Lac, Larry S. Zweifel, Erik S. Carlson
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Tyrosine hydroxylase (Th) expression has previously been reported in Purkinje cells (PCs) of rodents and humans, but its role in the regulation of behavior is not understood. Catecholamines are well known for facilitating cognitive behaviors and are
Externí odkaz:
https://doaj.org/article/e412d00db9334e8fbe4a78c21cfc592e
Autor:
Avery C. Hunker, Marta E. Soden, Dasha Krayushkina, Gabriel Heymann, Rajeshwar Awatramani, Larry S. Zweifel
Publikováno v:
Cell Reports, Vol 30, Iss 12, Pp 4303-4316.e6 (2020)
Summary: Mice engineered for conditional, cell type-specific gene inactivation have dominated the field of mouse genetics because of the high efficiency of Cre-loxP-mediated recombination. Recent advances in CRISPR/Cas9 technologies have provided alt
Externí odkaz:
https://doaj.org/article/f916781c7e144b2eadb9e2cec1859172