Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Larry Park"'
Autor:
Taneli Heikkinen, Timo Bragge, Juha Kuosmanen, Teija Parkkari, Sanna Gustafsson, Mei Kwan, Jose Beltran, Afshin Ghavami, Srinivasa Subramaniam, Neelam Shahani, Uri Nimrod Ramírez-Jarquín, Larry Park, Ignacio Muñoz-Sanjuán, Deanna M Marchionini
Publikováno v:
PLoS ONE, Vol 16, Iss 10, p e0258486 (2021)
Huntington's disease (HD) results from an expansion mutation in the polyglutamine tract in huntingtin. Although huntingtin is ubiquitously expressed in the body, the striatum suffers the most severe pathology. Rhes is a Ras-related small GTP-binding
Externí odkaz:
https://doaj.org/article/5d08393a3e9247bea54802339f2736c8
Autor:
Liliana Menalled, Bassem F. El-Khodor, Monica Patry, Mayte Suárez-Fariñas, Samantha J. Orenstein, Benjamin Zahasky, Christina Leahy, Vanessa Wheeler, X. William Yang, Marcy MacDonald, A. Jennifer Morton, Gill Bates, Janet Leeds, Larry Park, David Howland, Ethan Signer, Allan Tobin, Daniela Brunner
Publikováno v:
Neurobiology of Disease, Vol 35, Iss 3, Pp 319-336 (2009)
Huntington's disease (HD) is one of the few neurodegenerative diseases with a known genetic cause, knowledge that has enabled the creation of animal models using genetic manipulations that aim to recapitulate HD pathology. The study of behavioral and
Externí odkaz:
https://doaj.org/article/af9fd89edd134459a71f0f5fc6d5f00a
Autor:
Liliana B Menalled, Andrea E Kudwa, Steve Oakeshott, Andrew Farrar, Neil Paterson, Igor Filippov, Sam Miller, Mei Kwan, Michael Olsen, Jose Beltran, Justin Torello, Jon Fitzpatrick, Richard Mushlin, Kimberly Cox, Kristi McConnell, Matthew Mazzella, Dansha He, Georgina F Osborne, Rand Al-Nackkash, Gill P Bates, Pasi Tuunanen, Kimmo Lehtimaki, Dani Brunner, Afshin Ghavami, Sylvie Ramboz, Larry Park, Douglas Macdonald, Ignacio Munoz-Sanjuan, David Howland
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e99520 (2014)
Huntington's disease (HD) is an autosomal dominant, progressive neurodegenerative disorder caused by expansion of CAG repeats in the huntingtin gene. Tissue transglutaminase 2 (TG2), a multi-functional enzyme, was found to be increased both in HD pat
Externí odkaz:
https://doaj.org/article/32ac64f0a9ee4c26afbcfdfbe927af3c
Autor:
Michal Mielcarek, Christian Landles, Andreas Weiss, Amyaouch Bradaia, Tamara Seredenina, Linda Inuabasi, Georgina F Osborne, Kristian Wadel, Chrystelle Touller, Rachel Butler, Janette Robertson, Sophie A Franklin, Donna L Smith, Larry Park, Paul A Marks, Erich E Wanker, Eric N Olson, Ruth Luthi-Carter, Herman van der Putten, Vahri Beaumont, Gillian P Bates
Publikováno v:
PLoS Biology, Vol 11, Iss 11, p e1001717 (2013)
Histone deacetylase (HDAC) 4 is a transcriptional repressor that contains a glutamine-rich domain. We hypothesised that it may be involved in the molecular pathogenesis of Huntington's disease (HD), a protein-folding neurodegenerative disorder caused
Externí odkaz:
https://doaj.org/article/36f0a78b62114715a37984063f3cb2d9
Autor:
Liliana B Menalled, Monica Patry, Natalie Ragland, Phillip A S Lowden, Jennifer Goodman, Jennie Minnich, Benjamin Zahasky, Larry Park, Janet Leeds, David Howland, Ethan Signer, Allan J Tobin, Daniela Brunner
Publikováno v:
PLoS ONE, Vol 5, Iss 3, p e9793 (2010)
Previous studies of the effects of coenzyme Q10 and minocycline on mouse models of Huntington's disease have produced conflicting results regarding their efficacy in behavioral tests. Using our recently published best practices for husbandry and test
Externí odkaz:
https://doaj.org/article/4fa4ff5e21dd404d8e4ec783503ea5d3
Autor:
Georg Kempf, Ignacio Munoz-Sanjuan, Alexandros Patsilinakos, Matteo Andreini, Stefania Colarusso, Vincenzo Summa, Jesus Maria Ontoria Ontoria, Federica Ferrigno, Paola Fezzardi, Steven J. Harper, Leticia Toledo Sherman, Stefan Steinbacher, Ilaria Biancofiore, Esther Torrente, Martin Augustin, Elisabetta Bianchi, Larry Park, Alberto Bresciani, Robert Pacifici, Celia Dominguez
Publikováno v:
ACS Med Chem Lett
[Image: see text] The NRF2-ARE pathway is an intrinsic mechanism of defense against oxidative stress. Inhibition of the interaction between NRF2 and its main negative regulator KEAP1 is an attractive strategy toward neuroprotective agents. We report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::697530dc3724a96d48064e27557ca038
https://doi.org/10.1021/acsmedchemlett.9b00594
https://doi.org/10.1021/acsmedchemlett.9b00594
Autor:
Rob Gill, Jim Rosinski, Viktoria Andreeva, Richard A. Blevins, Jian Chen, Anastasia Shneyderman, Larry Park, Jeff Aaronson, Vahri Beaumont, Kabenla Armah, Irina Murasheva, Giovanni Coppola, Thomas F. Vogt, Ignacio Munoz-Sanjuan
Publikováno v:
Journal of Huntington's disease. 10(3)
HDinHD (Huntington’s Disease in High Definition; HDinHD.org) is an open online portal for the HD research community that presents a synthesized view of HD-related scientific data. Here, we present a broad overview of HDinHD and highlight the newly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1b47702138e6b88f10448f37db48312
https://pubmed.ncbi.nlm.nih.gov/34397420
https://pubmed.ncbi.nlm.nih.gov/34397420
Autor:
Mei Kwan, Fernando E. Padovan-Neto, Anthony R. West, Conor H. Murray, Lauren Jurkowski, Grace E. Stutzmann, Afshin Ghavami, Vahri Beaumont, Larry Park
Publikováno v:
Nitric Oxide. 83:40-50
In Huntington's disease (HD), corticostriatal and striatopallidal projection neurons preferentially degenerate as a result of mutant huntingtin expression. Pathological deficits in nitric oxide (NO) signaling have also been reported in corticostriata
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50ab254bfffac99b65393454edbdd9ac
https://doi.org/10.1016/j.niox.2018.12.002
https://doi.org/10.1016/j.niox.2018.12.002
Autor:
Jose Beltran, Teija Parkkari, Sanna Gustafsson, Neelam Shahani, Afshin Ghavami, Larry Park, Taneli Heikkinen, Mei Kwan, Deanna Marchionini, Srinivasa Subramaniam, Juha Kuosmanen, Uri Nimrod Ramírez-Jarquín, Timo Bragge, Ignacio Munoz-Sanjuan
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 10, p e0258486 (2021)
PLoS ONE, Vol 16, Iss 10, p e0258486 (2021)
Huntington’s disease (HD) results from an expansion mutation in the polyglutamine tract in huntingtin. Although huntingtin is ubiquitously expressed in the body, the striatum suffers the most severe pathology. Rhes is a Ras-related small GTP-bindin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6878ef4acd983462325493f313aadebc
https://pubmed.ncbi.nlm.nih.gov/34648564
https://pubmed.ncbi.nlm.nih.gov/34648564
Autor:
Paola Fezzardi, Steven J. Harper, Alberto Bresciani, Licia Tomei, Leticia-Toledo Sherman, Ignacio Munoz-Sajuan, Larry Park, Antonino Missineo, Mauro Cerretani, Robert Pacifici, Celia Dominquez, Daniele Moretti, Sara Tambone
Publikováno v:
Free radical biologymedicine. 162
Oxidative stress has been associated with pathogenesis in several diseases including Huntington's disease (HD), a neurodegenerative disorder caused by a mutation in the huntingtin gene. Oxidative stress induced reactive oxygen species (ROS) are norma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c125dfcb529779046473cfcc08c87c5
https://pubmed.ncbi.nlm.nih.gov/33096251
https://pubmed.ncbi.nlm.nih.gov/33096251