Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Larry P. Feigen"'
Autor:
S.G. Panzer-Knodle, Kam F. Fok, Larry P. Feigen, Steven Paul Adams, Nancy S. Nicholson, Foe S. Tjoeng
Publikováno v:
International Journal of Peptide and Protein Research. 38:124-130
Tetrapeptides containing the sequence Arg-Gly-Asp (RGD) antagonize fibrinogen binding to its platelet receptor (gp IIb/IIIa, integrin alpha IIb beta 3) and inhibit platelet aggregation in vitro. The peptides RGDS and RGDY(Me)-NH2 were rapidly degrade
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d67a4cc0688e8be95fbe04ff42431fa
https://doi.org/10.1111/j.1399-3011.1991.tb01419.x
https://doi.org/10.1111/j.1399-3011.1991.tb01419.x
Autor:
Joseph C. Loftus, Jeffrey W. Smith, Jeffery Alan Zablocki, Carol Halloran, Larry P. Feigen, Mark H. Ginsberg
Publikováno v:
Journal of Biological Chemistry. 271:2033-2039
The integrin alpha subunits play a major role in the regulation of ligand binding specificity. To gain further insight into the regions of the alpha subunits that regulate ligand specificity, we have utilized alpha v / alpha IIb chimeras to identify
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6450afa0684d02e7d0290907dfa1b049
https://doi.org/10.1074/jbc.271.4.2033
https://doi.org/10.1074/jbc.271.4.2033
Autor:
Jeffery Alan Zablocki, Neal F. Haas, Anita K. Salyers, S.G. Panzer-Knodle, Beatrice B. Taite, Larry P. Feigen, Marc Herin, Kay Broschat, Lucy W. King, Phillipe Jacqmin, Bradley T. Keller, V. Wayne Engleman, Nancy S. Nicholson, James A. Szalony
Publikováno v:
Circulation. 91:403-410
Background Intravenous therapy has been shown to be beneficial in the prevention of acute platelet-associated thrombotic events. However, orally active agents would be advantageous for chronic therapy. Fibrinogen receptor antagonists block the fibrin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::336714372463ad6d39ffad92b62638ee
https://doi.org/10.1161/01.cir.91.2.403
https://doi.org/10.1161/01.cir.91.2.403
Autor:
Dudley E. McMackins, Mihaly V. Toth, Henry E. Dayringer, J. G. Rico, P. R. Bovy, Nancy S. Nicholson, Anita K. Salyers, Beatrice B. Taite, Jeffery Alan Zablocki, Larry P. Feigen, Thomas E. Rogers, Shashidhar N. Rao, Mark E. Zupec, Robert Bruce Garland, Steven Paul Adams, M. Herin, R. J. Lindmark, Foe S. Tjoeng, S.G. Panzer-Knodle, Masateru Miyano
Publikováno v:
Bioorganic & Medicinal Chemistry. 2:881-895
The evolutionary process from the Arg-Gly-Asp-Phe (RGDF) tetrapeptide to potent orally active anti-platelet agents is presented. The RGD sequence is an important component in the recognition of fibrinogen by its platelet receptor GP IIb-IIIa (integri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82ff7ca1e73492c493b88cb344c8d089
https://doi.org/10.1016/s0968-0896(00)82038-6
https://doi.org/10.1016/s0968-0896(00)82038-6
Publikováno v:
Journal of Clinical Investigation. 94:928-936
The metabolic and functional alterations which occur during the acute phase of nephrotoxic nephritis (NTN) in rats, a model of immune-mediated glomerulonephritis, result from a cooperative interaction between PMNs and platelets (PLTs). In consequence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3a7819b063885b15cee7a54dd545338
https://doi.org/10.1172/jci117459
https://doi.org/10.1172/jci117459
Publikováno v:
Expert Opinion on Investigational Drugs. 3:437-448
Fibrinogen receptor antagonists represent a potential new form of antithrombotic therapy for the treatment or prevention of vascular complications including: myocardial infarct, unstable angina, stroke and complications during percutaneous translumin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed98ef05fd0ed987610c6fdd1530a1e5
https://doi.org/10.1517/13543784.3.5.437
https://doi.org/10.1517/13543784.3.5.437
Autor:
Larry P. Feigen, S.G. Panzer-Knodle, P. Jacqmin, V. W. Engleman, J. D. Page, Nancy S. Nicholson, Jeffery Alan Zablocki
Publikováno v:
Platelets. 6(5)
In order to compare binding of small peptide mimetics on activated vs resting platelets and with fibrinogen (fgn) on activated platelets, the binding of [(3)H]-SC-52012, a low molecular weight (483) mimetic of the RGDF sequence present in fgn, was ev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2d2811bc34d9832d3335c7dc3f49dfc
https://pubmed.ncbi.nlm.nih.gov/21043715
https://pubmed.ncbi.nlm.nih.gov/21043715
Autor:
Larry P. Feigen, Leo G. Frederick, James A. Szalony, Lucy W. King, Nancy S. Nicholson, Anita K. Salyers, Osman D. Suleymanov, Beatrice B. Taite
Publikováno v:
Circulation. 98(8)
Background —Inhibition of platelet aggregation by preventing the binding of fibrinogen to glycoprotein (GP) IIb/IIIa on activated platelets results in antithrombotic activity. We report on the antithrombotic effect of xemilofiban (SC-54684A), an or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dffe22c0e819358242abf0fefbc14bf7
https://pubmed.ncbi.nlm.nih.gov/9727553
https://pubmed.ncbi.nlm.nih.gov/9727553
Autor:
Neal F. Haas, David M. Lansky, Beatrice B. Taite, Nancy S. Nicholson, Anita K. Salyers, Jimmy D. Page, James A. Szalony, Larry P. Feigen, S.G. Panzer-Knodle
Publikováno v:
American heart journal. 135(5 Pt 2)
Optical aggregometry, traditionally used to assess platelet function, is highly dependent on sample preparation and technical procedure; as a result, data from various laboratories can be quite variable. In a study designed to assess the sources of v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b18d211dcd17134dbeeb8a43003dfd35
https://pubmed.ncbi.nlm.nih.gov/9588396
https://pubmed.ncbi.nlm.nih.gov/9588396
Autor:
Larry P. Feigen, Juan J. Badimon, Lina Badimon, James H. Chesebro, Beat J. Meyer, D. A. Baron, Valentin Fuster
Publikováno v:
European journal of clinical investigation. 27(7)
Platelet aggregation and thrombosis play an important role in the onset of acute coronary events. Regardless of the stimulus for activation, platelet thrombus formation is ultimately regulated through the IIb/IIIa receptor complex. The effects of ora
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bfe4266a7a1522f8f35576fdd219673
https://pubmed.ncbi.nlm.nih.gov/9263744
https://pubmed.ncbi.nlm.nih.gov/9263744