Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Larry Nummy"'
Autor:
Denis Byrne, Zhengxu S. Han, Philomen DeCroos, Bo Qu, Frank Roschangar, Larry Nummy, Yibo Xu, Jinhua J. Song, Jon C. Lorenz, Ling Wu, Chris H. Senanayake, Kanwar Sidhu, Heewon Lee
Publikováno v:
Organic Process Research & Development. 23:263-268
Process development for a scalable and green synthesis of chiral tert-butanesulfinamide (TBSA) on a multikilogram scale is reported. The process is based on the identification of a chiral sulfinyl transfer agent, benzo[1,3]oxathiozin-2-one, that cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1afdd5f0b1773f3abbf934a4948f431c
https://doi.org/10.1021/acs.oprd.8b00399
https://doi.org/10.1021/acs.oprd.8b00399
Autor:
Xiao-Jun Wang, Dirk Weber, Dhileep Krishnamurthy, Denis Byrne, Larry Nummy, Chris H. Senanayake, Nathan K. Yee, Li Zhang
Publikováno v:
Organic Letters. 16:4090-4093
An efficient production synthesis of the SGLT-2 inhibitor Empagliflozin (5) from acid 1 is described. The key tactical stage involves I/Mg exchange of aryl iodide 2 followed by addition to glucono lactone 3 in THF. Subsequent in situ treatment of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f8d1ad85405482191863dec36bb03b2
https://doi.org/10.1021/ol501755h
https://doi.org/10.1021/ol501755h
Autor:
Kanwar Sidhu, Wenjun Tang, Azad Hossain, Nizar Haddad, Larry Nummy, Heewon Lee, Nathan K. Yee, Bruce Z. Lu, Ajith Premasiri, Xiufeng Sun, Jun Wang, Jolaine Savoie, Wenjie Li, Chris H. Senanayake, Adil Duran, Sonia Rodriguez, Bo Qu, Nitinchandra D. Patel, Jon C. Lorenz
Publikováno v:
Organic Process Research & Development. 17:1061-1065
A highly electron-rich P-chiral bis(trialkylphosphane) ligand MeO-BIBOP (1) was efficiently synthesized on large scale. The MeO-BIBOP–rhodium complex exhibited remarkably high reactivities (up to 200,000 TON) for the hydrogenation of N-acetyl enami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03c8cd398107ca35a17cf0fbeb1ed1c3
https://doi.org/10.1021/op400055z
https://doi.org/10.1021/op400055z
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 54:763-768
The lymphocyte function-associated antigen-1 (LFA-1) is an essential component in normal immune system function and is a target for drug discovery for its broad therapeutic potential in treating inflammatory diseases. Here, we report the synthesis of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8994a0da6bc37e6a4a572fd53ecbb5a8
https://doi.org/10.1002/jlcr.1920
https://doi.org/10.1002/jlcr.1920
Autor:
Shengli Ma, Jean-Nicolas Desrosiers, Alexander Sienkiewicz, Larry Nummy, Daniel R. Fandrick, Jinhua J. Song, Xudong Wei, Sanjit Sanyal, Heewon Lee, Xingzhong Zeng, Christopher B. Kelly, Chris H. Senanayake, Max Sarvestani, Scot J. Campbell, Nelu Grinberg
Publikováno v:
Organic letters. 16(6)
A scalable de novo synthesis of difluoromethyl pyridines from inexpensive materials is reported. The pyridyl subunit is built around the difluoromethyl group rather than a late stage introduction of this moiety. This user-friendly approach allows acc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::698ed9f10ee1a00013c020512a482ce3
https://pubmed.ncbi.nlm.nih.gov/24601851
https://pubmed.ncbi.nlm.nih.gov/24601851
Publikováno v:
The Journal of Organic Chemistry. 63:326-330
A practical synthesis of the enantiomerically pure BIRZ-227 (1), a LTB4 inhibitor, has been developed. The key steps include the effective synthesis of the trans-diarylpyrrolidinone (±)-8 and the enzymatic resolution of N-acetoxymethyl pyrrolidinone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0008ca77525f1c61f9af4a3d2fdfd74
https://doi.org/10.1021/jo971605p
https://doi.org/10.1021/jo971605p
Autor:
Heewon Lee, Larry Nummy, Nathan K. Yee, Thomas Fachinger, Shengli Ma, Daniel R. Fandrick, Jonathan T. Reeves, Frank Roschangar, Denis Byrne, Max Sarvestani, Sherry Shen, Chris H. Senanayake, Bikshandarkoil A. Narayanan, Jinhua J. Song, Bo Qu, Phil DeCroos, Victor Fuchs, Nelu Grinberg, Zhibin Li, Burkhard Jäger, Ashish Chitroda, Jon C. Lorenz, Oliver Niemeier, Earl Spinelli, Soojin Kim, Nizar Haddad, Michael Brenner, Zhulin Tan, Xiufeng Sun, Varsolona Richard J, Sonia Rodriguez, Ajith Premasiri, Scot Campbell, Nina C. Gonnella
Publikováno v:
The Journal of organic chemistry. 78(8)
The development of a large scale synthesis of the glucocorticoid agonist BI 653048 BS H3PO4 (1·H3PO4) is presented. A key trifluoromethyl ketone intermediate 22 containing an N-(4-methoxyphenyl)ethyl amide was prepared by an enolization/bromine-magn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::417034dc1c222b56e6e25fded0bb5608
https://pubmed.ncbi.nlm.nih.gov/23544738
https://pubmed.ncbi.nlm.nih.gov/23544738
Publikováno v:
ChemInform. 29
A practical synthesis of the enantiomerically pure BIRZ-227 (1), a LTB4 inhibitor, has been developed. The key steps include the effective synthesis of the trans-diarylpyrrolidinone (±)-8 and the enzymatic resolution of N-acetoxymethyl pyrrolidinone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e53b14c22bfbce91cfe046a8572d8d0
https://doi.org/10.1002/chin.199824106
https://doi.org/10.1002/chin.199824106
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:2279-2280
An efficient synthesis of 5-hydroxyalbuterol is described starting from 2,3-dihydroxybenzoic acid. The key step utilizes the Stille cross-coupling reaction to install the side-chain functionality.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e24bed0c1f5e9f5d776661c17fa483d
https://doi.org/10.1016/0960-894x(96)00413-1
https://doi.org/10.1016/0960-894x(96)00413-1
Autor:
Kenneth B. Roberts, Julian Adams, Jane Frommer, Larry Nummy, William H. Rastetter, John W. Frost
Publikováno v:
Chemischer Informationsdienst. 10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d02b380d9a213ae1afa01fc55e59ce27
https://doi.org/10.1002/chin.197934171
https://doi.org/10.1002/chin.197934171