Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Larry Murphy"'
Publikováno v:
Journal of Visualized Experiments : JoVE
Platelet inventory management based on screening microparticle content in platelet concentrates is a new quality improvement initiative for hospital blood banks. Cells fragment off microparticles (MP) when they are stressed. Blood and blood component
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26242dd36d8c8bbfaca2d352a1a88839
https://pubmed.ncbi.nlm.nih.gov/29443045
https://pubmed.ncbi.nlm.nih.gov/29443045
Publikováno v:
American Journal of Agricultural and Biological Sciences. 9:294-298
Crop recovery of applied Phosphorus (P) fertilizer can be low, especially during season of low soil temperature, which decreases plant root growth and nutrient uptake. The H 2PO 4 - or HPO 4 -2 anions readily react with soil cations such as Calcium (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2be4222e6223bc959dbb6d82d3fc64f1
https://doi.org/10.3844/ajabssp.2014.294.298
https://doi.org/10.3844/ajabssp.2014.294.298
Publikováno v:
AIChE Journal. 54:1895-1900
A new approach is presented for combinatorial development of polymer nanocomposites with compositional gradients (CGs). The CGs were developed using transient processing conditions in twin screw extrusion with small quantities of expensive nanoscale
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::394297e85fe74cdb8f01ffd523461b52
https://doi.org/10.1002/aic.11505
https://doi.org/10.1002/aic.11505
Autor:
Stephen H. Eisennagel, Tianbao Lu, Larry Murphy, Malini Dasgupta, John C. Spurlino, Fedde Cynthia L, Richard Soll, Aihua Wang, Roger F. Bone, Carl Crysler, Bruce E. Tomczuk
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:1495-1498
Although thrombin has been extensively researched with many examples of potent and selective inhibitors, the key characteristics of oral bioavailability and long half-life have been elusive. We report here a novel series non-peptidic phenyl-based, hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb73e120be853dc5fac2135bf0a37a1d
https://doi.org/10.1016/s0960-894x(03)00125-2
https://doi.org/10.1016/s0960-894x(03)00125-2
Autor:
Carl R. Illig, Larry Murphy, Roger F. Bone, Tianbao Lu, Richard M. Soll, F. Raymond Salemme, John C. Spurlino, Bruce E. Tomczuk
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:79-82
The structure–activity relationships of a novel series of non-amide-based thrombin inhibitors are described. Exploration of the P2 and the aryl binding region for this series has identified optimal groups for achieving nanomolar potency. The bindin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8157e82d3b892ad1187077c6e3827196
https://doi.org/10.1016/s0960-894x(99)00617-4
https://doi.org/10.1016/s0960-894x(99)00617-4
Autor:
Stephen Eisennagel, Carl R. Illig, Richard Soll, Fedde Cynthia L, Tianbao Lu, F R Salemme, Bruce E. Tomczuk, Larry Murphy, John C. Spurlino, Roger F. Bone
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:1-4
We describe a new class of potent, non-amide-based small molecule thrombin inhibitors in which an amidinohydrazone is used as a guanidine bioisostere on a non-peptide scaffold. Compound 4 exhibits nM inhibition of thrombin, is selective for thrombin,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3368ea7452c90710cafb3176005bc5d
https://doi.org/10.1016/s0960-894x(99)00632-0
https://doi.org/10.1016/s0960-894x(99)00632-0
Autor:
Roger F. Bone, Carl R. Illig, B. Tomczuk, F R Salemme, Larry Murphy, Richard M. Soll, John C. Spurlino, Tianbao Lu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:1595-1600
We describe the in vitro evaluation and crystallographic analysis of a new class of potent and selective, non-amino acid-based, small-molecule thrombin inhibitors, exemplified by 14. This class of achiral inhibitors lacks an amide-based backbone, exh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9199a9f8588714eb34a40273dca10c28
https://doi.org/10.1016/s0960-894x(98)00290-x
https://doi.org/10.1016/s0960-894x(98)00290-x
Publikováno v:
Life Sciences. 59:1739-1744
Cisplatinum in a concentration (4.3 × 10−6M) corresponding to the therapeutic plasma concentration for cancer patients was found to cause a marked enhancement of magnesium efflux and uptake in perfused frog myocardium. The magnesium content of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c887c9aeb1d5d065dfddbe0b938bf74
https://doi.org/10.1016/s0024-3205(96)00511-5
https://doi.org/10.1016/s0024-3205(96)00511-5
Autor:
John C. Spurlino, Larry Murphy, B. Tomczuk, Carl R. Illig, Tianbao Lu, Richard M. Soll, Roger F. Bone, F R Salemme
Publikováno v:
ChemInform. 29
We describe the in vitro evaluation and crystallographic analysis of a new class of potent and selective, non-amino acid-based, small-molecule thrombin inhibitors, exemplified by 14. This class of achiral inhibitors lacks an amide-based backbone, exh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf26b9f114b25ce569b7967fbaeff66f
https://doi.org/10.1002/chin.199846158
https://doi.org/10.1002/chin.199846158