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Autor:
Kurt B. Pearl, Elaine C. Lee, Larry Morin, Nancy J. Benz, Rodger F. Henry, Margaret C. Hsu, Sema Z. Ariman, Francoix X. Gueffier, David M. Barnes, Daniel J. Plata, Anthony R. Haight, Matthew J. Peterson, David R. Willcox
Publikováno v:
Organic Process Research & Development. 10:751-756
ABT-492 has been under development at Abbott Laboratories as a quinolone antibiotic. A convergent syntheses was utilized to prepare the compound on a multi-kilogram scale. Difficulties in isolation of intermediates were overcome by developing control