Výsledky vyhledávání - "Larry Matherly"

Akademický článek

FOXQ1 recruits the MLL complex to activate transcription of EMT and promote breast cancer metastasis

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)

Forkhead box transcription factor, FOXQ1 is reported to promote epithelial-mesenchymal transition (EMT) and cancer metastasis. Here the authors show that FOXQ1 recruits the KMT2/MLL histone methyltransferase complex as a transcriptional coactivator t

Externí odkaz: https://doaj.org/article/fb2c929fd9f444428d14613bbb55b90c

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FOXQ1 recruits the MLL complex to activate transcription of EMT and promote breast cancer metastasis

Publikováno v: Nature communications. 13(1)

Aberrant expression of the Forkhead box transcription factor, FOXQ1, is a prevalent mechanism of epithelial-mesenchymal transition (EMT) and metastasis in multiple carcinoma types. However, it remains unknown how FOXQ1 regulates gene expression. Here

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67cafaa73b1c5bbbe693d9e47cb85999
https://pubmed.ncbi.nlm.nih.gov/36319643

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Abstract 2348: Targeting mitochondrial and cytosolic one-carbon metabolism in epithelial ovarian cancer via folate receptor alpha

Autor: Jennifer Wong-Roushar, Aamod Dekhne, Charles E. Dann, Lisa Polin, Xun Bao, Seongho Kim, Jade M. Katinas, Adrianne Wallace-Povirk, Jose Cardiel Nunez, Md. Junayed Nayeen, Khushbu Shah, Zhanjun Hou, Aleem Gangjee, Carrie O'Connor, Jing Li, Larry Matherly

Publikováno v: Cancer Research. 81:2348-2348

Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy. Though most patients initially respond to platinum-based therapy, the likelihood of disease reoccurrence is nearly 100%. Thus, new tumor-selective therapies for EOC are urgent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c590b449a67250dbda800df6bc929bdd
https://doi.org/10.1158/1538-7445.am2021-2348

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Abstract 511: Targeted one-carbon (1C) metabolism inhibitors: Design, synthesis and biological evaluation of novel 5-substituted pyrrolo[3,2-d]pyrimidines with pyridyl- and ortho-fluoropyridyl glutamate side chains as selective folate receptors substrates

Autor: Zhanjun Hou, Arpit Doshi, Larry Matherly, Aleem Gangjee, Adrianne Wallace-Povirk, Carrie O'Connor

Publikováno v: Cancer Research. 80:511-511

One-carbon (1C) metabolism, in tumor cells, provides basic metabolites needed for proliferation and is compartmentalized into the cytosol and mitochondria. The key enzymes in 1C metabolism are de novo purine biosynthesis catalyzing enzymes, glycinami

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0b66a6b2e8b09ac16f77887682160992
https://doi.org/10.1158/1538-7445.am2020-511

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Abstract 2798: Folate receptor-targeted cancer chemotherapy with novel 6-substituted thieno[2,3-d]pyrimidine compounds with nitrogen and fluorine containing aromatic side chains as de novo purine biosynthesis inhibitors

Autor: Adrianne Wallace Povrik, Carrie O. Connor, Larry Matherly, Aleem Gangjee, Nian Tong, Jianjun Hou

Publikováno v: Cancer Research. 78:2798-2798

Targeted cancer chemotherapy inhibits the growth of cancer cells by interfering with critical pathways required for tumor progression. Three major transporters are involved in membrane transport of folates into mammalian cells and include the reduced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::195d876fb8e30b40824567afaa2b8278
https://doi.org/10.1158/1538-7445.am2018-2798

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Abstract 1658: 5N-substituted pyrrolo[3,2-d]pyrimidines: Tumor-targeted agents with first-in-class dual inhibition of serine hydroxymethyl transferase 2 and 5-amino-4-imidazolecarboxamide ribonucleotide formyl transferase enzymes

Autor: Aamod Dekhne, Aleem Gangjee, Larry Matherly, Khushbu Shah, Zhanjun Hou

Publikováno v: Cancer Research. 78:1658-1658

Design, modeling and synthesis of pyrrolo[3,2-d]pyrimidine analogs were carried out based on the concept of dual mechanisms-of-action for achieving maximal antitumor efficacy. Tumor-targeted delivery via agents that are selectively transported by the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c38793122f47d8a00c4458999d34453a
https://doi.org/10.1158/1538-7445.am2018-1658

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Akademický článek

Preface.

Autor: Larry Matherly

Publikováno v: Cancer & Metastasis Reviews; Mar2007, Vol. 26 Issue 1, p3-4, 2p

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