Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Larry M. C. Chow"'
Autor:
Bo Tang, Kwai Man Lau, Yunxin Zhu, Chihao Shao, Wai-Ting Wong, Larry M. C. Chow, Clarence T. T. Wong
Publikováno v:
Pharmaceutics, Vol 16, Iss 1, p 71 (2024)
Delivering bioactive proteins into cells without carriers presents significant challenges in biomedical applications due to limited cell membrane permeability and the need for targeted delivery. Here, we introduce a novel carrier-free method that add
Externí odkaz:
https://doaj.org/article/0caeb3b8fb77445485d4ff5e60824df5
Autor:
Wenqin Sun, Iris L. K. Wong, Helen Ka-Wai Law, Xiaochun Su, Terry C. F. Chan, Gege Sun, Xinqing Yang, Xingkai Wang, Tak Hang Chan, Shengbiao Wan, Larry M. C. Chow
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4377 (2023)
The modulation of P-glycoprotein (P-gp, ABCB1) can reverse multidrug resistance (MDR) and potentiate the efficacy of anticancer drugs. Tea polyphenols, such as epigallocatechin gallate (EGCG), have low P-gp-modulating activity, with an EC50 over 10
Externí odkaz:
https://doaj.org/article/f5da34f96969411982c70abf9011fd0d
Autor:
Jason W. Y. Kan, Clare S. W. Yan, Iris L. K. Wong, Xiaochun Su, Zhen Liu, Tak Hang Chan, Larry M. C. Chow
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 23, p 15299 (2022)
Biotransformation of flavonoid dimer FD18 resulted in an active metabolite FM04. It was more druggable because of its improved physicochemical properties. FM04 (EC50 = 83 nM) was 1.8-fold more potent than FD18 in reversing P-glycoprotein (P-gp)-media
Externí odkaz:
https://doaj.org/article/ddd118db7cb740df9d822fbe8a8fcd1d
Autor:
Tsz Cheung Chong, Iris L. K. Wong, Jiahua Cui, Man Chun Law, Xuezhen Zhu, Xuesen Hu, Jason W. Y. Kan, Clare S. W. Yan, Tak Hang Chan, Larry M. C. Chow
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 21, p 13261 (2022)
Overexpression of breast cancer resistance transporter (BCRP/ABCG2) in cancers has been explained for the failure of chemotherapy in clinic. Inhibition of the transport activity of BCRP during chemotherapy should reverse multidrug resistance. In this
Externí odkaz:
https://doaj.org/article/b470e512a9744189a7e3f58b7d2ec6a0
Autor:
Rui Zhang, Chris Y. Cheung, Sang-Uk Seo, Hang Liu, Lakhansing Pardeshi, Koon Ho Wong, Larry M. C. Chow, Mary P. Chau, Yixiang Wang, Ah Ra Lee, Woon Yong Kwon, Sheng Chen, Bill Kwan-wai Chan, Kenneth Wong, Richard K. W. Choy, Ben C. B. Ko
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Macrophages play an important role in the host defense mechanism. In response to infection, macrophages activate a genetic program of pro-inflammatory response to kill any invading pathogen, and initiate an adaptive immune response. We have identifie
Externí odkaz:
https://doaj.org/article/73c5cecb1e1348179fadfe22111b3410
Publikováno v:
Marine Drugs, Vol 12, Iss 10, Pp 5209-5221 (2014)
In this study, new marine ningalin B analogues containing a piperazine or a benzoloxy group at ring C have been synthesized and evaluated on their P-gp modulating activity in human breast cancer and leukemia cell lines. Their structure-activity relat
Externí odkaz:
https://doaj.org/article/6a8ebc29db2b475295478b6bbec1e5e2
Autor:
Cheryl C Y Loh, Rossarin Suwanarusk, Yan Quan Lee, Kitti W K Chan, Kit-Ying Choy, Laurent Rénia, Bruce Russell, Martin J Lear, François H Nosten, Kevin S W Tan, Larry M C Chow
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e110800 (2014)
Chloroquine was a cheap, extremely effective drug against Plasmodium falciparum until resistance arose. One approach to reversing resistance is the inhibition of chloroquine efflux from its site of action, the parasite digestive vacuole. Chloroquine
Externí odkaz:
https://doaj.org/article/22ef07f27e9c4fb3925b41315300f303
Autor:
Peng, Li, Yunjiao, He, Teng, Chen, Kit-Ying, Choy, Tsun Sing, Chow, Iris L K, Wong, Xinqing, Yang, Wenqin, Sun, Xiaochun, Su, Tak-Hang, Chan, Larry M C, Chow
Publikováno v:
Molecular cancer therapeutics. 20(1)
Staphylococcal nuclease domain-containing protein 1 (SND1) is a multifunctional oncoprotein overexpressed in breast cancer. Binding of metadherin (MTDH) to SND1 results in the stabilization of SND1 and is important in the initiation and progression o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a7899791e4970e3f13c88ae835fc466f
https://pubmed.ncbi.nlm.nih.gov/33268570
https://pubmed.ncbi.nlm.nih.gov/33268570
Autor:
Kin-Fai, Chan, Yunzhe, Zhao, Brendan A, Burkett, Iris L K, Wong, Larry M C, Chow, Tak Hang, Chan
Publikováno v:
Journal of medicinal chemistry. 49(23)
Much effort has been spent on searching for better P-glycoprotein- (P-gp-) based multidrug resistance (MDR) modulators. Our approach was to target the binding sites of P-gp using dimers of dietary flavonoids. A series of apigenin-based flavonoid dime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b7b551355c4203f0025696796ccb0610
https://pubmed.ncbi.nlm.nih.gov/17154505
https://pubmed.ncbi.nlm.nih.gov/17154505
Autor:
Matthew A, Dodge, Ross F, Waller, Larry M C, Chow, Muhammad M, Zaman, Leanne M, Cotton, Malcolm J, McConville, Dyann F, Wirth
Publikováno v:
Molecular microbiology. 51(6)
Upregulation of the multidrug resistance protein 1 (LeMDR1) in the protozoan parasite, Leishmania enriettii, confers resistance to hydrophobic drugs such as vinblastine, but increases the sensitivity of these parasites to the mitochondrial drug, rhod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7aff427596380f97b91a504ef7e6aed2
https://pubmed.ncbi.nlm.nih.gov/15009885
https://pubmed.ncbi.nlm.nih.gov/15009885