Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Larry Lai"'
Autor:
David Kung-Chun Chiu, Aki Pui-Wah Tse, Iris Ming-Jing Xu, Jane Di Cui, Robin Kit-Ho Lai, Lynna Lan Li, Hui-Yu Koh, Felice Ho-Ching Tsang, Larry Lai Wei, Chun-Ming Wong, Irene Oi-Lin Ng, Carmen Chak-Lui Wong
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Myeloid-derived suppressor cells (MDSCs) promote tumor immune escape. Here, the authors show that in hepatocellular carcinoma, hypoxia induces the expression of ENTPD2 on cancer cells leading to elevated extracellular 5′-AMP, which in turn promote
Externí odkaz:
https://doaj.org/article/360a1c2886224e2282f3c6518e7a0d34
Autor:
Carmen Chak-Lui Wong, Sandy Leung-Kuen Au, Aki Pui-Wah Tse, Iris Ming-Jing Xu, Robin Kit-Ho Lai, David Kung-Chun Chiu, Larry Lai Wei, Dorothy Ngo-Yin Fan, Felice Ho-Ching Tsang, Regina Cheuk-Lam Lo, Chun-Ming Wong, Irene Oi-Lin Ng
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e115036 (2014)
Hepatocellular carcinoma (HCC) is an aggressive tumor, with a high mortality rate due to late symptom presentation and frequent tumor recurrences and metastasis. It is also a rapidly growing tumor supported by different metabolic mechanisms; neverthe
Externí odkaz:
https://doaj.org/article/1533705541764799a9dc21c71df083eb
Autor:
Tzu-Wei Lee, Cheng-Yu Chen, Kuan Chen, Chao-Wei Tso, Hui-Hsien Lin, Ying-Liang Larry Lai, Fei-Ting Hsu, Hsiao-Wen Chung, Hua-Shan Liu
Publikováno v:
Tomography, Vol 7, Iss 2, Pp 107-119 (2021)
The presence of a swallow-tail sign in the nigrosome-1 with hyperintense signal shown on the susceptibility-weighted imaging (SWI) has been shown to be sensitive in detecting the abnormal iron deposits in this area. A systematic evaluation in healthy
Externí odkaz:
https://doaj.org/article/6d7a5647433c436e8125edee0d920d22
Autor:
Chiu, David Kung-Chun, Yuen, Vincent Wai-Hin, Cheu, Jacinth Wing-Sum, Wei, Larry Lai, Ting, Vox, Fehlings, Michael, Sumatoh, Hermi, Nardin, Alessandra, Newell, Evan W., Ng, Irene Oi-Lin, Yau, Thomas Chung-Cheung, Wong, Chun-Ming, Wong, Carmen Chak-Lui
Publikováno v:
In Gastroenterology August 2020 159(2):609-623
Autor:
Carmen Chak-Lui Wong, Irene Oi-Lin Ng, Maria Pik Wong, Chun-Ming Wong, Derek Lee, Cheuk-Ting Law, Larry Lai Wei, Aki Pui-Wah Tse, David Kung-Chun Chiu, Iris Ming-Jing Xu, Robin Kit-Ho Lai
Figure S1: NDUFA4L2 is over-expressed in human solid cancers.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e0acfe4217f52bb1124f84bb78dbb00
https://doi.org/10.1158/1078-0432.22459829
https://doi.org/10.1158/1078-0432.22459829
Autor:
Carmen Chak-Lui Wong, Irene Oi-Lin Ng, Maria Pik Wong, Chun-Ming Wong, Derek Lee, Cheuk-Ting Law, Larry Lai Wei, Aki Pui-Wah Tse, David Kung-Chun Chiu, Iris Ming-Jing Xu, Robin Kit-Ho Lai
Figure S4. NDUFA4 is preferentially expressed under normoxia.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34e398a8e1745ef9407c41f8e32e3680
https://doi.org/10.1158/1078-0432.22459820.v1
https://doi.org/10.1158/1078-0432.22459820.v1
Autor:
Carmen Chak-Lui Wong, Irene Oi-Lin Ng, Maria Pik Wong, Chun-Ming Wong, Derek Lee, Cheuk-Ting Law, Larry Lai Wei, Aki Pui-Wah Tse, David Kung-Chun Chiu, Iris Ming-Jing Xu, Robin Kit-Ho Lai
Figure S5. Knockdown of NDUFA4L2 increases mitochondrial membrane potential and ROS production in hypoxia.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cb6286eae05dedf464182551f6faf76
https://doi.org/10.1158/1078-0432.22459814.v1
https://doi.org/10.1158/1078-0432.22459814.v1
Autor:
Carmen Chak-Lui Wong, Irene Oi-Lin Ng, Maria Pik Wong, Chun-Ming Wong, Derek Lee, Cheuk-Ting Law, Larry Lai Wei, Aki Pui-Wah Tse, David Kung-Chun Chiu, Iris Ming-Jing Xu, Robin Kit-Ho Lai
Purpose: Hepatocellular carcinoma (HCC) lacks effective curative therapy. Hypoxia is commonly found in HCC. Hypoxia elicits a series of protumorigenic responses through hypoxia-inducible factor-1 (HIF1). Better understanding of the metabolic adaptati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72a27ae54910671a9af0037b79d003c9
https://doi.org/10.1158/1078-0432.c.6524321.v1
https://doi.org/10.1158/1078-0432.c.6524321.v1
Autor:
Carmen Chak-Lui Wong, Irene Oi-Lin Ng, Maria Pik Wong, Chun-Ming Wong, Derek Lee, Cheuk-Ting Law, Larry Lai Wei, Aki Pui-Wah Tse, David Kung-Chun Chiu, Iris Ming-Jing Xu, Robin Kit-Ho Lai
Figure S7. Knockdown of NDUFA4L2 suppresses tumor growth and reduces cell migratory ability.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dbfa78fdc1198fab4d4dcbd897f95d6
https://doi.org/10.1158/1078-0432.22459808
https://doi.org/10.1158/1078-0432.22459808
Autor:
Carmen Chak-Lui Wong, Irene Oi-Lin Ng, Maria Pik Wong, Chun-Ming Wong, Derek Lee, Cheuk-Ting Law, Larry Lai Wei, Aki Pui-Wah Tse, David Kung-Chun Chiu, Iris Ming-Jing Xu, Robin Kit-Ho Lai
Figure S2. Knockdown of HIF-1α or HIF-2α, and knockout of HIF-1α are confirmed by western blot analysis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0d694d5affcae27506617e14fc061a9
https://doi.org/10.1158/1078-0432.22459826
https://doi.org/10.1158/1078-0432.22459826