Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Larry L Swift"'
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0181046 (2017)
Previous studies in our laboratory have established the presence of MTP in both white and brown adipose tissue in mice as well as in 3T3-L1 cells. Additional studies demonstrated an increase in MTP levels as 3T3-L1 cells differentiate into adipocytes
Externí odkaz:
https://doaj.org/article/bf4019adc011449abff4ebb4fa56ce86
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0147252 (2016)
Microsomal triglyceride transfer protein (MTP) is essential for the assembly of triglyceride-rich apolipoprotein B-containing lipoproteins. Previous studies in our laboratory identified a novel splice variant of MTP in mice that we named MTP-B. MTP-B
Externí odkaz:
https://doaj.org/article/ae92b7e6bcf142a5b40256a1eddf1c8d
Autor:
Joseph D Love, Takashi Suzuki, Delia B Robinson, Carla M Harris, Joyce E Johnson, Peter J Mohler, W Gray Jerome, Larry L Swift
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0135598 (2015)
Lipid droplets are intracellular energy storage organelles composed of a hydrophobic core of neutral lipid, surrounded by a monolayer of phospholipid and a diverse array of proteins. The function of the vast majority of these proteins with regard to
Externí odkaz:
https://doaj.org/article/bb6176c5fc6149aeb0252f67a8f6e0c5
Autor:
Nicole A. Braun, Peter J. Mohler, Karl H. Weisgraber, Alyssa H. Hasty, MacRae F. Linton, Patricia G. Yancey, Yan Ru Su, Sergio Fazio, Larry L. Swift
Publikováno v:
Journal of Lipid Research, Vol 47, Iss 6, Pp 1176-1186 (2006)
We have investigated apolipoprotein E (apoE) recycling in Chinese hamster ovary (CHO) cells, a peripheral cell that does not produce lipoproteins or express apoE. Using a pulse-chase protocol in which cells were pulsed with 125I-apoE-VLDL and chased
Externí odkaz:
https://doaj.org/article/88d633af94714d3085a72cb191c30e99
Autor:
Alyssa H. Hasty, Michelle R. Plummer, Karl H. Weisgraber, MacRae F. Linton, Sergio Fazio, Larry L. Swift
Publikováno v:
Journal of Lipid Research, Vol 46, Iss 7, Pp 1433-1439 (2005)
The ability of apolipoprotein E (apoE) to be spared degradation in lysosomes and to recycle to the cell surface has been demonstrated by our group and others, but its physiologic relevance is unknown. In this study, we characterized apoE recycling in
Externí odkaz:
https://doaj.org/article/0363cbc54b114d5d9a94e211bb2794b3
Autor:
Monica H. Farkas, Karl H. Weisgraber, Virginia L. Shepherd, MacRae F. Linton, Sergio Fazio, Larry L. Swift
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 8, Pp 1546-1554 (2004)
A portion of apolipoprotein E (apoE) internalized by hepatocytes is spared degradation and is recycled. To investigate the intracellular routing of recycling apoE, primary hepatocyte cultures from LDL receptor-deficient mice and mice deficient in rec
Externí odkaz:
https://doaj.org/article/3cb64289569d41dfbad44b25b7a1078a
Autor:
Larry L. Swift, Mei-Ying Zhu, Bharati Kakkad, Aneta Jovanovska, M. Diana Neely, Klara Valyi-Nagy, Richard L. Roberts, David E. Ong, W. Gray Jerome
Publikováno v:
Journal of Lipid Research, Vol 44, Iss 10, Pp 1841-1849 (2003)
Microsomal triglyceride transfer protein (MTP) is essential for the assembly of apolipoprotein B-containing lipoproteins. Within the endoplasmic reticulum, it transfers lipid from the membrane to the forming lipoprotein. Recent evidence suggests that
Externí odkaz:
https://doaj.org/article/426f98572e004e82ace3fb8534e9b38f
Autor:
John-Anthony Coppola, Martha J. Shrubsole, Jennings Hardee, Maya N White, Sunny S Cai, Timothy Su, Ginger L. Milne, Qi Dai, Larry L. Swift, Sandra Motley, Stephanie M. Martin, Qiuyin Cai, Harvey J. Murff, Wei Zheng
Publikováno v:
Eur J Cancer Prev
OBJECTIVE: Fish oil supplementation may represent a potential chemopreventive agent for reducing colorectal cancer risk. Fish oil’s mechanism of action is unknown but presumed to be related to eicosanoid modification. The purpose of this study was
Publikováno v:
Journal of Lipid Research, Vol 42, Iss 2, Pp 218-224 (2001)
The assembly of very low density lipoproteins (VLDL) by hepatocytes is believed to occur via a two-step process. The first step is the formation of a dense phospholipid and protein-rich particle that is believed to be converted to VLDL by the additio
Externí odkaz:
https://doaj.org/article/0e0b34e6d13549b797b5a08f89293790
Determination of the lower threshold of apolipoprotein E resulting in remnant lipoprotein clearance1
Publikováno v:
Journal of Lipid Research, Vol 40, Iss 8, Pp 1529-1538 (1999)
Apolipoprotein E (apoE) is the ligand for receptor-mediated clearance of remnant lipoproteins. ApoE at concentrations only 10% of normal, achieved through transplantation of wild-type marrow into apoE(–/–) mice, is sufficient for the maintenance
Externí odkaz:
https://doaj.org/article/9f9c72aaa9fc46e19b915d91527f71c6