Zobrazeno 1 - 10
of 152
pro vyhledávání: '"Larry Kedes"'
Publikováno v:
BioTechniques, Vol 29, Iss 3, Pp 602-609 (2000)
We have developed a simple scheme for characterizing ligand-receptor binding and post-binding activity on living cells. Our approach makes use of green fluorescent protein (GFP) as an auto-fluorescent tag to label protein ligands. We have constructed
Externí odkaz:
https://doaj.org/article/80e09833ad8a40679c8df536389377f3
Autor:
Grant Campany, Larry Kedes
Publikováno v:
Nature Genetics. 43:1055-1058
The Archon Genomics X PRIZE presented by MEDCO is a $10 million prize for whole human genome sequencing that will test 100 samples and establish a defined method for determining quality and cost per genome. The contest will entail a head-to-head comp
Autor:
Ray-Chang Wu, Kozo Kaibuchi, Dai Nishimura, Hiroshi Nishida, Mutsuki Amano, Toru Tanaka, Larry Kedes, Yasuo Hamamori, Tatsuya Iso
Publikováno v:
Journal of Biological Chemistry. 281:15320-15329
Rho-associated coiled-coil protein kinase (ROCK) is an effector for the small GTPase Rho and plays a pivotal role in diverse cellular activities, including cell adhesion, cytokinesis, and gene expression, primarily through an alteration of actin cyto
Autor:
Masashi Arai, Toru Tanaka, Miki Yamazaki, Keiko Kawai-Kowase, Toshitaka Maeno, Hideo Akiyama, Hiroshi Doi, Hiroko Sato, Larry Kedes, Tatsuya Iso, Eiichi Okamoto, Hiroyoshi Kanai, Masahiko Kurabayashi
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 25:2328-2334
Objective— Myocardin is a coactivator of serum response factor (SRF) required for vascular smooth muscle cell (VSMC) differentiation. HERP1 is a transcriptional repressor, which is abundantly expressed in vascular system and is known to function as
Autor:
Lali K. Medina-Kauwe, Sarah F. Hamm-Alvarez, Hasmik Agadjanian, Xinhua Chen, Larry Kedes, M. MacVeigh, Altan Rentsendorj, M Cirivello
Publikováno v:
Gene Therapy. 12:225-237
The interesting discovery reported here that soluble adenovirus serotype 5 (Ad5) fiber proteins enter cells without the virus was a serendipitous result during our development of Ad5 capsid proteins as nonviral gene transfer vectors. The Ad5 capsid f
Autor:
G. Paolo Dotto, Gudrun Valdimarsdottir, Peter ten Dijke, Marie-José Goumans, Fumiko Itoh, Yasuo Hamamori, Susumu Itoh, Tatsuya Iso, Larry Kedes, Mitsuyasu Kato
Publikováno v:
The EMBO Journal. 23:541-551
Notch and bone morphogenetic protein signaling pathways are important for cellular differentiation, and both have been implicated in vascular development. In many cases the two pathways act similarly, but antagonistic effects have also been reported.
Publikováno v:
The Annals of Thoracic Surgery. 75:1450-1456
Most myocardial cell transplant studies focus on demonstration of improved function; however, such improvement depends on the development of appropriate tissue structure. Thus, our aim was to assess the architectural changes that occurred after cell
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 23:543-553
Notch signaling is an extremely conserved and widely used mechanism regulating cell fate in metazoans. Interaction of Notch receptors (Notch) with their ligands (Delta-like or Jagged) leads to cleavage of the Notch intracellular domain (NICD) that mi
Publikováno v:
Heart Failure Reviews. 8:201-211
Heart failure, frequently the consequence of irreversible myocardial damage with subsequent formation of akinetic scar tissue, is a highly prevalent disease, and in its advanced stages associated with high mortality. The transplantation of exogenous
Publikováno v:
Journal of Biological Chemistry. 277:6598-6607
Notch signaling is involved in many cell fate determination events in metazoans. Ligand binding results in proteolytic cleavage to release the signal-transducing Notch intracellular domain (NICD). The nuclear protein RBP-J kappa, when complexed with