Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Larry John Black"'
Autor:
Raymond F. Kauffman, D C Williams, A Bekele, E R Rowley, W R Bensch, R Bendele, Larry John Black, D E Magee, Masahiko Sato, G J Cullinan
There is a medical need for an agent with the positive effects of estrogen on bone and the cardiovascular system, but without the negative effects on reproductive tissue. Raloxifene (LY139481 HCI) is a benzothiophene derivative that binds to the estr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb6238e4e6c949a9bb93215c390e1cf6
https://europepmc.org/articles/PMC293730/
https://europepmc.org/articles/PMC293730/
Autor:
Robin L. Goode, Larry John Black
Publikováno v:
Life Sciences. 26:1453-1458
Dose response uterotrophic and antiuterotrophic activity of antiestrogens was examined in immature rats, immature mice and adult ovariectomized mice. LY117018 was the most active antagonist and the least estrogenic, while tamoxifen induced the greate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e73eecc3e46b8d2728e855263baa5d4
https://doi.org/10.1016/0024-3205(80)90049-1
https://doi.org/10.1016/0024-3205(80)90049-1
Autor:
Larry John Black
Publikováno v:
Fertility and Sterility. 25:575-585
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eab2309213bc59008b83dd594ffeb7f
https://doi.org/10.1016/s0015-0282(16)40513-3
https://doi.org/10.1016/s0015-0282(16)40513-3
Autor:
Andrew Pike, Charles David Jones, Larry John Black, Allen R. Thompson, James A. Clemens, Mary K. Peters, Julie F. Falcone, Mary G. Jevnikar
Publikováno v:
Journal of Medicinal Chemistry. 27:1057-1066
In an effort to prepare nonsteroidal antiestrogens demonstrating greater antagonism and less intrinsic estrogenicity than those currently available, a series of 3-aroyl-2-arylbenzo[b]thiophene derivatives was synthesized. These compounds were prepare
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce3861982acfe6aaabc912a7d59c53df
https://doi.org/10.1021/jm00374a021
https://doi.org/10.1021/jm00374a021
Publikováno v:
Molecular and Cellular Endocrinology. 22:95-103
Interaction of tamoxifen, trioxifene and LY117018 with cytosol-estrogen receptors from immature rat uteri was compared. Determination of relative binding affinity (RBA) by competition with [3H] estradiol under various assay conditions revealed that t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fee9b193ac7dd4d633186c1d4d564ce
https://doi.org/10.1016/0303-7207(81)90105-2
https://doi.org/10.1016/0303-7207(81)90105-2
Autor:
Larry John Black, Russell J. Kraay
Publikováno v:
Experimental Biology and Medicine. 133:376-379
The action of estrogens on target organs has been amply reviewed (1-3). Since the report by Jensen and Jacobson (4), demonstrating accumulation and retention of estradiol in rat uterine tissue, many investigators have turned to the use of tritiated e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fca29ba1fb779fdd9ac6b674481e8016
https://doi.org/10.3181/00379727-133-34477
https://doi.org/10.3181/00379727-133-34477
Publikováno v:
Cancer Chemotherapy and Selective Drug Development ISBN: 9781461338390
Presently, attempts to pharmacologically antagonize estrogen action are impeded by the weak estrogenic activity of the currently available estrogen antagonists. Most antiestrogens, rather than being pure antagonists, possess varying degrees of estrog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2828714b07b432bcb2c2911b296e6b56
https://doi.org/10.1007/978-1-4613-3837-6_69
https://doi.org/10.1007/978-1-4613-3837-6_69
Autor:
Robin L. Goode, Larry John Black
Publikováno v:
Endocrinology. 109(3)
The influence of LY117018 and tamoxifen on established uterotropic influence of estradiol was examined in immature ovariectomized rats. When LY117018 was introduced on the fourth day of estradiol treatment, it regressed the uterotropic effect of estr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e082caa44f8cc3a6cb2011b988f51cc9
https://pubmed.ncbi.nlm.nih.gov/7262030
https://pubmed.ncbi.nlm.nih.gov/7262030
Publikováno v:
Toxicology and applied pharmacology. 91(2)
Fenarimol (alpha-(2-chlorophenyl)-alpha(4-chlorophenyl)-5-pyrimidine-methanol), a pyrimidine carbinol agricultural fungicide, was previously reported to cause a dose-related decrease in fertility in rats (K. S. Hirsch, E. R. Adams, D. G. Hoffman, J.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91d2fa6d0a0780b5fc05a5f0a538381a
https://pubmed.ncbi.nlm.nih.gov/3672523
https://pubmed.ncbi.nlm.nih.gov/3672523
Publikováno v:
Journal of medicinal chemistry. 22(8)
Acylation of the sodio anion of beta-tetralone with phenyl anisoate, followed by a Grignard reaction of the resultant 4 with 4-methoxyphenylmagnesium bromide, gave rise to two novel dihydronaphthalene isomers 5 and 6. Regioselective demethylation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92875e654c310812f4a536337e808f82
https://pubmed.ncbi.nlm.nih.gov/490541
https://pubmed.ncbi.nlm.nih.gov/490541