Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Larry James Markoski"'
Autor:
Peter J. Tummino, James Saunders, Stephen J. Gracheck, Bradley Dean Tait, J. V. N. Vara Prasad, Joanne I. Brodfuehrer, Christopher Andrew Gajda, Krishna R. Iyer, Tod P. Holler, Susan Elizabeth Hagen, Steven VanderRoest, Edmund L. Ellsworth, Fred E. Boyer, Carolyn Nouhan, Donna Ferguson, Larry James Markoski, Michael Sinz, Donald Hupe, Elizabeth A. Lunney, John M. Domagala
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:1481-1486
Dihydropyran-2-ones possessing amino and carboxamide functionalities on 3-SPh (2-tert-butyl, 5-methyl) ring were synthesized and evaluated for their antiviral activities. Both the enantiomers of inhibitor 15 were synthesized. The in vitro resistance
Autor:
Peter J. Tummino, J.V.N. Vara Prasad, Steven VanderRoest, Stephen J. Gracheck, Larry James Markoski, A. Urumov, Joanne Brodfuehrer, Michael Sinz, Donald Hupe, Elizabeth A. Lunney, S V Gulnik, Neil Graham, Alexander Palovsky, James M. Sanders, Edmund L. Ellsworth, John M. Domagala, Christopher Andrew Gajda, Carolyn Nouhan, Susan Elizabeth Hagen, Frederick E. Boyer, Krishna R. Iyer, Tod P. Holler, Greg Zeikus, John W. Erickson, Donna Ferguson, Eric Andrew Zeikus, Bradley D. Tait
Publikováno v:
Journal of medicinal chemistry. 43(5)
On the basis of previous SAR findings and molecular modeling studies, a series of compounds were synthesized which possessed various sulfonyl moieties substituted at the 4-position of the C-3 phenyl ring substituent of the dihydropyran-2-one ring sys
Autor:
John R. Rubin, Neil Graham, Krishna R. Iyer, Steven VanderRoest, Elizabeth A. Lunney, Larry James Markoski, Christopher Andrew Gajda, Bradley D. Tait, James Saunders, Harriet W. Hamilton, Greg Zeikus, John M. Domagala, Stephen J. Gracheck, John W. Erickson, Alexander Pavlovsky, Christine Humblet, Donna Ferguson, J.V.N. Vara Prasad, Eric Andrew Zeikus, Edmund L. Ellsworth, Bruce A. Steinbaugh, Frederick E. Boyer, A. Urumov, Michael Sinz, Donald Hupe, Susan Elizabeth Hagen, Carolyn Nouhan, S V Gulnik, Joanne Brodfuehrer, Tod P. Holler, Peter J. Tummino
Publikováno v:
Bioorganicmedicinal chemistry. 7(12)
With the insight generated by the availability of X-ray crystal structures of various 5,6-dihydropyran-2-ones bound to HIV PR, inhibitors possessing various alkyl groups at the 6-position of 5,6-dihydropyran-2-one ring were synthesized. The inhibitor