Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Larry J. Ross"'
Autor:
Justin A. Shapiro, Al Claiborne, Joanna B. Goldberg, Matthew R. Redinbo, E. Lucile White, Robert Bostwick, William M. Wuest, Derek Parsonage, John J. Varga, William G. Walton, Larry J. Ross
Publikováno v:
ChemMedChem. 14:78-82
Antibiotics with novel mechanisms of action are desperately needed to combat the increasing rates of multidrug-resistant infections. Bacterial pantothenate kinase (PanK) has emerged as a target of interest to cut off the biosynthesis of coenzyme A. H
Autor:
Benjamin Y. Owusu, Troy E. Messick, Namita Bansal, Robert A. Galemmo, Larry J. Ross, Sanjay Goel, Phanindra K. M. Venukadasula, Lidija Klampfer
Publikováno v:
Oncotarget
The binding of hepatocyte growth factor (HGF) to its receptor MET activates a signaling cascade that promotes cell survival, proliferation, cell scattering, migration and invasion of malignant cells. HGF is secreted by cancer cells or by tumor-associ
Autor:
Corinne E. Griguer, Mark J. Suto, Maaike Everts, Claudia R. Oliva, Wei Zhang, Lynn Rasmussen, Shannon M. Bailey, Tahireh Markert, Douglas R. Moellering, E. Lucile White, Larry J. Ross
Publikováno v:
The Journal of biological chemistry. 291(46)
The enzyme cytochrome c oxidase (CcO) or complex IV (EC 1.9.3.1) is a large transmembrane protein complex that serves as the last enzyme in the respiratory electron transport chain of eukaryotic mitochondria. CcO promotes the switch from glycolytic t
Autor:
Subramaniam Ananthan, Mark J. Suto, Yimin Wang, Ling Zhai, Rebecca J. Boohaker, Bo Xu, Rongbao Li, Indira Padmalayam, Robert Bostwick, Larry J. Ross, Joseph A. Maddry, Vandana V. Gupta, E. Lucile White, Yonghe Li, Wenyan Lu, Wei Zhang, Corinne E. Augelli-Szafran
Historically, drugs used in the treatment of cancers also tend to cause damage to healthy cells while affecting cancer cells. Therefore, the identification of novel agents that act specifically against cancer cells remains a high priority in the sear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::926601737b739c9b0fb91d22a2b35a18
https://europepmc.org/articles/PMC5488687/
https://europepmc.org/articles/PMC5488687/
Autor:
Robert C. Reynolds, Judith V. Hobrath, Hava Lofton, Malini Rajagopalan, Bini Mathew, Michele Connelly, Larry J. Ross, R. Kiplin Guy
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 10, p e0164100 (2016)
PLoS ONE, Vol 11, Iss 10, p e0164100 (2016)
A variety of commercial analogs and a newer series of Sulindac derivatives were screened for inhibition of M. tuberculosis (Mtb) in vitro and specifically as inhibitors of the essential mycobacterial tubulin homolog, FtsZ. Due to the ease of preparin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b9f03efe906432fe91387d4f5c0e32e
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-308919
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-308919
Publikováno v:
Bioorganic & Medicinal Chemistry
Graphical abstract Novel inhibitors of the SARS-3CLpro were identified using a combination of structure-based virtual screening and biological evaluation.
Severe acute respiratory syndrome is a highly infectious upper respiratory tract disease c
Severe acute respiratory syndrome is a highly infectious upper respiratory tract disease c
Publikováno v:
Tuberculosis. 93:398-400
High throughput phenotypic screening of large commercially available libraries through two NIH programs has produced thousands of potentially interesting hits for further development as antitubercular agents. Unfortunately, these screens do not suppl
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:3161-3164
The preparation of a new 2-carbamoyl pteridine, its activity data against FtsZ from M. tuberculosis (Mtb), and in vitro antibacterial data against Mtb strain H37Ra are presented.
Publikováno v:
Journal of Antimicrobial Chemotherapy. 50:111-114
Compounds originally designed as putative tubulin inhibitors were tested as antitubercular agents for inhibition of the Mycobacterium tuberculosis analogue of tubulin, FtsZ. Initial screening of 200 2-alkoxycarbonylpyridines found several that inhibi
Autor:
A. Heroux, David W. Borhani, Larry J. Ross, James R. Piper, Vibha Pathak, Anthony E. Klon, Cheryl A. Johnson
Publikováno v:
Journal of Molecular Biology. 320:677-693
The crystal structures of two human dihydrofolate reductase (hDHFR) ternary complexes, each with bound NADPH cofactor and a lipophilic antifolate inhibitor, have been determined at atomic resolution. The potent inhibitors 6-([5-quinolylamino]methyl)-