Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Larry Harshyne"'
Autor:
Dante J. Merlino, Jennifer M. Johnson, Madalina Tuluc, Stacey Gargano, Robert Stapp, Larry Harshyne, Benjamin E. Leiby, Adam Flanders, Ralph Zinner, Rita Axelrod, Joseph Curry, David M. Cognetti, Kyle Mannion, Young J. Kim, Ulrich Rodeck, Athanassios Argiris, Adam J. Luginbuhl
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
PD-1 blockade represents a promising treatment in patients with head and neck squamous cell carcinoma (HNSCC). We analyzed results of a neoadjuvant randomized window-of-opportunity trial of nivolumab plus/minus tadalafil to investigate whether immuno
Externí odkaz:
https://doaj.org/article/14e95860288848139f6fcb4a69f21798
Autor:
Ayan Tyagi Kumar, Alexander Knops, Brian Swendseid, Ubaldo Martinez-Outschoom, Larry Harshyne, Nancy Philp, Ulrich Rodeck, Adam Luginbuhl, David Cognetti, Jennifer Johnson, Joseph Curry
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Background: Head and neck squamous cell carcinoma (HNSCC) exists within a microenvironment rich in immune cells. Macrophages are particularly abundant in and around tumor tissue, and have been implicated in the growth, malignancy, and persistence of
Externí odkaz:
https://doaj.org/article/d0a0495edf2a45fc9cf3b3fab2724ca9
Autor:
Joseph M. Curry, Jennifer Johnson, Mehri Mollaee, Patrick Tassone, Dev Amin, Alexander Knops, Diana Whitaker-Menezes, My G. Mahoney, Andrew South, Ulrich Rodeck, Tingting Zhan, Larry Harshyne, Nancy Philp, Adam Luginbuhl, David Cognetti, Madalina Tuluc, Ubaldo Martinez-Outschoorn
Publikováno v:
Frontiers in Oncology, Vol 8 (2018)
Background: Metformin, an oral anti-hyperglycemic drug which inhibits mitochondrial complex I and oxidative phosphorylation has been reported to correlate with improved outcomes in head and neck squamous cell carcinoma (HNSCC) and other cancers. This
Externí odkaz:
https://doaj.org/article/c9c4b795175a4c32b103ba961cafc5b2
Autor:
Joseph Curry, Angela Alnemri, Ramez Philips, Michele Fiorella, Sarah Sussman, Robert Stapp, Charalambos Solomides, Larry Harshyne, Andrew South, Adam Luginbuhl, Madalina Tuluc, Ubaldo Martinez‐Outschoorn, Athanassios Argiris, Alban Linnenbach, Jennifer Johnson
Publikováno v:
The LaryngoscopeBIBLIOGRAPHY.
To analyze CD8+ and FoxP3+ T-cell cellular density (CD) and intercellular distances (ID) in head and neck squamous cell carcinoma (HNSCC) samples from a neoadjuvant trial of durvalumab +/- metformin.Paired pre- and post-treatment primary HNSCC tumor
Autor:
Rhonda B. Kean, Wenyin Shi, Mark T. Curtis, Emily K. Bongiorno, Larry Harshyne, Kiran Talekar, Haisong Liu, Maria Werner-Wasik, Lawrence C. Kenyon, Mikhail Prosniak, Donald Y. Ye, Lyndon Kim, Adam E. Flanders, D. Craig Hooper, Charles B. Scott, Kara Pigott, David W. Andrews, Nina L. Martinez, Sami Sauma, Kevin Judy, Kofi-Buaku Atsina, Mark A. Exley, Samantha Garcia
Publikováno v:
Clinical Cancer Research. 27:1912-1922
Purpose: Despite standard of care (SOC) established by Stupp, glioblastoma remains a uniformly poor prognosis. We evaluated IGV-001, which combines autologous glioblastoma tumor cells and an antisense oligonucleotide against IGF type 1 receptor (IMV-
Autor:
Voichita Bar-Ad, Jean H. Hoffman-Censits, Madalina Tuluc, Andrew Song, Adam P. Dicker, Rhonda B. Kean, Jianqing Lin, Larry Harshyne, Douglas C. Hooper, Bo Lu, Jennifer Johnson, Jennifer Louie, Robert B. Den, Benjamin E. Leiby, Sandeep Deshmukh, Colette M. Shaw, William Kevin Kelly, Mark D. Hurwitz, Sherin Philipose
Publikováno v:
American Journal of Clinical Oncology. 43:82-86
Objectives There is no study published regarding the benefit of radiation therapy (RT) in combination with immune checkpoint inhibitors (ICIs) for the treatment of metastatic renal cell cancer (mRCC). This report is part of an exploratory study aimin
Autor:
Adam Luginbuhl, Jennifer Maria Johnson, Elizabeth R Scott, Larry Harshyne, Elizaveta Flerova Flerova, Madalina Tuluc, Stacey Gargano, Benjamin Leiby, Matthew O. Old, Nolan Seim, Joseph M. Curry, David M. Cognetti, Athanassios Argiris
Publikováno v:
Journal of Clinical Oncology. 40:6070-6070
6070 Background: Indoleamine 2,3-dioxygenase (IDO) catalyzes the degradation of tryptophan to kynurenine. In order to improve the clinical efficacy of PD-1 inhibition, we designed a novel neoadjuvant trial to test the immunological and therapeutic ef
Autor:
Alban Linnenbach, Joseph Curry, Adam Luginbuhl, Larry Harshyne, Gaurav Kumar, Andrew P. South, Adam Ertel, Paolo Fortina
Immune checkpoint blockade (ICB) therapy has had a major impact on the clinical management of head and neck squamous cell carcinoma (HNSCC). However, clinical responses to ICB are observed in only a fraction of patients. In the present paper, we used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c361355576040ce2a41ee3eb6b834834
https://doi.org/10.1101/2021.03.30.437691
https://doi.org/10.1101/2021.03.30.437691
Autor:
Adam E. Flanders, Larry Harshyne, Ralph Zinner, Madalina Tuluc, Benjamin E. Leiby, Ulrich Rodeck, Rita Axelrod, Jennifer Johnson, Young J. Kim, David Cognetti, Dante J. Merlino, Athanassios Argiris, Joseph Curry, Kyle Mannion, Adam Luginbuhl, Stacey M. Gargano, Robert Stapp
Publikováno v:
Frontiers in Oncology
Frontiers in Oncology, Vol 10 (2020)
Frontiers in Oncology, Vol 10 (2020)
PD-1 blockade represents a promising treatment in patients with head and neck squamous cell carcinoma (HNSCC). We analyzed results of a neoadjuvant randomized window-of-opportunity trial of nivolumab plus/minus tadalafil to investigate whether immuno
Autor:
David W. Andrews, Mark T. Curtis, Lawrence C. Kenyon, Jonathan Gorky, James S. Schwaber, Rhonda B. Kean, Aurore Lebrun, Larry Harshyne, Michael Prosniak, D. Craig Hooper
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 206(7)
Patients with grade III anaplastic astrocytomas (AA) separate into survival cohorts based on the presence or absence of mutations in isocitrate dehydrogenase (IDH). Progression to glioblastoma (GBM), morphologically distinguishable by elevated microv