Reversal of MicroRNA Dysregulation in an Animal Model of Pulmonary Hypertension.

Autor: Igor B Gubrij, Amanda K Pangle, Li Pang, Larry G Johnson

Publikováno v: PLoS ONE, Vol 11, Iss 1, p e0147827 (2016)

Animals models have played an important role in enhancing our understanding of the pathogenesis of pulmonary arterial hypertension (PAH). Dysregulation of the profile of microRNAs (miRNAs) has been demonstrated in human tissues from PAH patients and

Externí odkaz: https://doaj.org/article/ac6359d93ceb4c87a57d6a35411ac841

Efficacy and safety of the elexacaftor plus tezacaftor plus ivacaftor combination regimen in people with cystic fibrosis homozygous for the F508del mutation

Autor: Harry G M Heijerman, Edward F McKone, Damian G Downey, Eva Van Braeckel, Steven M Rowe, Elizabeth Tullis, Marcus A Mall, John J Welter, Bonnie W Ramsey, Charlotte M McKee, Gautham Marigowda, Samuel M Moskowitz, David Waltz, Patrick R Sosnay, Christopher Simard, Neil Ahluwalia, Fengjuan Xuan, Yaohua Zhang, Jennifer L Taylor-Cousar, Karen S McCoy, Karen McCoy, Scott Donaldson, Seth Walker, James Chmiel, Ronald Rubenstein, Deborah K. Froh, Isabel Neuringer, Manu Jain, Kathryn Moffett, Jennifer L. Taylor-Cousar, Bruce Barnett, Gary Mueller, Patrick Flume, Floyd Livingston, Nighat Mehdi, Charlotte Teneback, John Welter, Raksha Jain, Dana Kissner, Kapilkumar Patel, Francisco J. Calimano, Jimmy Johannes, Cori Daines, Thomas Keens, Herschel Scher, Subramanyam Chittivelu, Sudhakar Reddivalam, Ross Carl Klingsberg, Larry G. Johnson, Stijn Verhulst, Patricia Macedo, Damien Downey, Gary Connett, Edward Nash, Nicholas Withers, Timothy Lee, Marleen Bakker, Harry Heijerman, Francois Vermeulen, Christiane Knoop, Elke De Wachter, Renske van der Meer, Petrus Merkus, Christof Majoor

Publikováno v: Lancet, 394(10212), 1940-1948. Elsevier Limited
VX17-445-103 Trial Group 2019, ' Efficacy and safety of the elexacaftor plus tezacaftor plus ivacaftor combination regimen in people with cystic fibrosis homozygous for the F508del mutation: a double-blind, randomised, phase 3 trial ', Lancet, vol. 394, no. 10212, pp. 1940 . https://doi.org/10.1016/S0140-6736(19)32597-8
Lancet
The Lancet, 394(10212), 1940. Elsevier Limited

BACKGROUND: Cystic fibrosis transmembrane conductance regulator (CFTR) modulators correct the basic defect caused by CFTR mutations. Improvements in health outcomes have been achieved with the combination of a CFTR corrector and potentiator in people

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::221e25362cf07bd88d1d3728962d9a50
http://www.scopus.com/inward/record.url?scp=85074786708&partnerID=8YFLogxK

Reversal of MicroRNA Dysregulation in an Animal Model of Pulmonary Hypertension

Autor: Larry G. Johnson, Amanda K. Pangle, Li Pang, Igor Gubrij

Publikováno v: PLoS ONE, Vol 11, Iss 1, p e0147827 (2016)
PLoS ONE

Background Animals models have played an important role in enhancing our understanding of the pathogenesis of pulmonary arterial hypertension (PAH). Dysregulation of the profile of microRNAs (miRNAs) has been demonstrated in human tissues from PAH pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2f2dcb3086548d9d255e8a7cc794779
http://europepmc.org/articles/PMC4731388?pdf=render

Pulmonary arterial hypertension: a review for an internist

Autor: Sridhar, Badireddi, Mohammad F, Siddiqui, Larry G, Johnson

Publikováno v: The Journal of the Arkansas Medical Society. 111(5)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5eebc6bbe8ab31186720774ca7f42155
https://pubmed.ncbi.nlm.nih.gov/25647976

Applications of imaging techniques to studies of epithelial tight junctions

Autor: Larry G. Johnson

Publikováno v: Advanced Drug Delivery Reviews. 57:111-121

The intercellular junctional complex, which consists of the tight junction (TJ), adherens junction, and desmosomes, mediates cell-cell adhesion in epithelia and endothelia. The TJ forms the apical-most portion of this complex in epithelia, serving as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0c846ce6fc26db87302afab03e831a9
https://doi.org/10.1016/j.addr.2004.08.004