Výsledky vyhledávání - "Larry Ereshefsky"

Akademický článek

Candidate inflammatory biomarkers display unique relationships with alpha-synuclein and correlate with measures of disease severity in subjects with Parkinson’s disease

Autor: Lori N. Eidson, George T. Kannarkat, Christopher J. Barnum, Jianjun Chang, Jaegwon Chung, Chelsea Caspell-Garcia, Peggy Taylor, Brit Mollenhauer, Michael G. Schlossmacher, Larry Ereshefsky, Mark Yen, Catherine Kopil, Mark Frasier, Kenneth Marek, Vicki S. Hertzberg, Malú G. Tansey

Publikováno v: Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-16 (2017)

Abstract Background Efforts to identify fluid biomarkers of Parkinson’s disease (PD) have intensified in the last decade. As the role of inflammation in PD pathophysiology becomes increasingly recognized, investigators aim to define inflammatory si

Externí odkaz: https://doaj.org/article/4759130fbf4b43dfb829cdfe656a57b3

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A Randomized, Double-Blind, Placebo-Controlled Study of the Effects of Two Sequential Doses of NV-5138/SPN-820 on Quantitative Electroencephalography in Healthy Adult Males

Autor: Leonard J Trejo, Roman Rosipal, Adrienne Moore, Brendan Lujan, Alisa Kosheleff, Larry Ereshefsky, Randy Owen, George Vlasuk

NV-5138 (or SPN-820) is a novel small molecule activator of the mechanistic target of rapamycin complex 1 (mTORC1) currently under development for use in treatment- resistant depression. This phase I study evaluated the safety, tolerability, and phar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e8cb6e3684b9b4dc9f4d86be31e0d2da
https://doi.org/10.31234/osf.io/hu7ba

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Diagnostic criteria for apathy in neurocognitive disorders

Publikováno v: Alzheimer'sdementia : the journal of the Alzheimer's Association. 17(12)

Introduction Apathy is common in neurocognitive disorders (NCD) but NCD-specific diagnostic criteria are needed. Methods The International Society for CNS Clinical Trials Methodology Apathy Work Group convened an expert group and sought input from ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f32fec21d286d4cc734cd29aa09abc4c
https://pubmed.ncbi.nlm.nih.gov/33949763

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A Phase 1B, randomized, double blind, placebo controlled, multiple-dose escalation study of NSI-189 phosphate, a neurogenic compound, in depressed patients

Autor: John A. Bilello, Bradford C. Dickerson, Gustavo Kinrys, Linda M. Thurmond, Marlene P. Freeman, Bettina B. Hoeppner, David Mischoulon, K Johe, Larry Ereshefsky, Maurizio Fava, Martina Flynn, J Johnstone, L G Gertsik, Brett A. English, Nikos Makris

Publikováno v: Molecular Psychiatry

We wanted to examine tolerability and efficacy of NSI-189, a benzylpiperizine-aminiopyridine neurogenic compound for treating major depressive disorder (MDD). This was a Phase 1B, double blind, randomized, placebo controlled, multiple-dose study with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a25b4fc6ebb87f3bb32943f0573d6db5
http://europepmc.org/articles/PMC5030464

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Candidate inflammatory biomarkers display unique relationships with alpha-synuclein and correlate with measures of disease severity in subjects with Parkinson’s disease

Autor: Catherine Kopil, Kenneth Marek, Brit Mollenhauer, Jianjun Chang, George T. Kannarkat, Vicki S. Hertzberg, Michael G. Schlossmacher, Jaegwon Chung, Peggy Taylor, Mark Yen, Larry Ereshefsky, Chelsea Caspell-Garcia, Lori N. Eidson, MariadeLourdes Tansey, Mark Frasier, Christopher J. Barnum

Publikováno v: Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-16 (2017)

Background Efforts to identify fluid biomarkers of Parkinson’s disease (PD) have intensified in the last decade. As the role of inflammation in PD pathophysiology becomes increasingly recognized, investigators aim to define inflammatory signatures

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0f9ff798d495f142c7a02f2ae2c5b8c
http://europepmc.org/articles/PMC5563061

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Effect of food on the pharmacokinetics of lurasidone: results of two randomized, open-label, crossover studies

Autor: Sheldon H. Preskorn, Yu-Yuan Chiu, Larry Ereshefsky, Antony Loebel, Nagaraju Poola

Publikováno v: Human Psychopharmacology: Clinical and Experimental. 28:495-505

Objective This study aimed to investigate the effect of prandial status and caloric and fat composition of meals on the pharmacokinetics of lurasidone. Methods Two randomized, open-label, crossover studies were conducted in clinically stable adults w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f4fa0a292311987b86fe9c82725eda1f
https://doi.org/10.1002/hup.2338

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Pharmacokinetic Profile of Orally Administered Scyllo-Inositol (Elnd005) in Plasma, Cerebrospinal Fluid and Brain, and Corresponding Effect on Amyloid-Beta in Healthy Subjects

Autor: Pamela Garzone, Victor Xu, Jesse M. Cedarbaum, Thao Tran, Susan Abushakra, Aleksandra Pastrak, Larry Ereshefsky, Stanford Jhee, Martin Koller, Brian D. Ross, Earvin Liang

Publikováno v: Clinical Pharmacology in Drug Development. 2:186-194

ELND005 (scyllo-inositol), an endogenous inositol stereoisomer, is being investigated as an oral treatment for Alzheimer's disease (AD). Pharmacokinetics of ELND005 in plasma, cerebrospinal fluid (CSF), and brain was characterized in healthy young su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1bab624abd53c5b659189ad55a033ad3
https://doi.org/10.1002/cpdd.14

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