Výsledky vyhledávání - "Larry E. Kahn"

Progenipoietins

Autor: Philip R. Streeter, William F. Hood, Tammy L. Thurman, John P. McKearn, Joseph K. Welply, Larry E Kahn, Woulfe Susan L, Nancy I. Minster, Joseph B. Monahan, Lillian E Vickery

Publikováno v: Experimental Hematology. 29:41-50

Objective The progenipoietins, a class of engineered proteins containing both fetal liver tyrosine kinase-3 and granulocyte colony-stimulating factor receptor agonist activities, were functionally characterized in vitro and in vivo. Materials and Met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d90635cd6e1fbecfb24c032d0c2be6da
https://doi.org/10.1016/s0301-472x(00)00616-0

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Biochemical, cellular, and anti-inflammatory properties of a potent, selective, orally bioavailable benzamide inhibitor of Rho kinase activity

Autor: Olga V. Nemirovskiy, Mihir D. Parikh, Monica B. Norton, Jay M. Wendling, Michael S. Davies, Robert J. Mourey, Lakshman E. Rajagopalan, Toni A. Steiner, Ben S. Zweifel, Hideaki Shimada, Christine M. Kornmeier, Thomas P. Misko, Jaime L. Masferrer, Maria A. Payne, Larry E. Kahn, Stephen A. Kolodziej, Richard F Loeffler, Brenda L. Case

Publikováno v: The Journal of pharmacology and experimental therapeutics. 333(3)

Rho kinase, is the most widely studied downstream effector of the small Rho GTPase RhoA. Two Rho kinase isoforms have been described and are frequently referred to in the literature as ROCK1 and ROCK2. The RhoA-Rho kinase pathway has been implicated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a050f8933535407b1ce23153cb1f8587
https://pubmed.ncbi.nlm.nih.gov/20228155

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Novel tight-binding inhibitory factor-kappaB kinase (IKK-2) inhibitors demonstrate target-specific anti-inflammatory activities in cellular assays and following oral and local delivery in an in vivo model of airway inflammation

Autor: Vicky Walker Holway, Neetu Venkatraman, Janice M. Thompson, Po-Chang Chiang, Sumathy Mathialagan, Larry E. Kahn, Cynthia D. Sommers, Horng-Chih Huang, Randall K. Rader, Debra M. Meyer, Julia A. Guzova, Debra S. Garner, Sheri L. Bonar, Yiding Hu, George Hu, Nandini Kishore, John F. Schindler

Publikováno v: The Journal of pharmacology and experimental therapeutics. 330(2)

Nuclear factor-kappaB (NF-kappaB) is one of the major families of transcription factors activated during the inflammatory response in asthma and chronic obstructive pulmonary disease. Inhibitory factor-kappaB kinase 2 (IKK-2) has been shown to play a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99c0d9117545548743363e2926d24326
https://pubmed.ncbi.nlm.nih.gov/19478133

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Systemic mobilization of antigen presenting cells, with a chimeric Flt-3 and G-CSF receptor agonist, during immunization of Macaca mulatta with HIV-1 antigens is insufficient to modulate immune responses or vaccine efficacy

Autor: Daniella Mortier, Larry E Kahn, Jonathan L. Heeney, Ralf Wagner, Dean L. Mann, Gerrit Koopman, Ann M. Farese, Woulfe Susan L, Thomas J. MacVittie, Henk Niphuis

Publikováno v: Vaccine. 23(33)

In order to improve the efficacy of current vaccine candidates against HIV/AIDS, we sought to strengthen the induction of immune responses via simultaneous in vivo mobilization of dendritic cells using a chimeric Flt-3 and G-CSF receptor agonists (Pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db1e088ac9dd0f04a8b247320af6de68
https://pubmed.ncbi.nlm.nih.gov/15896883

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Characterization of dendritic cells generated in vivo by an E. coli derived chimeric dual receptor agonist

Autor: Larry E, Kahn, Parul D, Doshi, Kelly L, McGarity, Mingfu, Yu, Christine P, Bono, Wen-Rong, Lie, Anne M, Rankin, Mary L, Smidt, Philip R, Streeter, Barbara K, Klein, Joseph K, Welply, Susan L, Woulfe

Publikováno v: Medical science monitor : international medical journal of experimental and clinical research. 8(12)

Progenipoietin-4 (ProGP-4) is an E. coli derived chimeric growth factor that activates the human Flt3 and G-CSF receptors. ProGP-4 possesses cross-species activity and treatment of mice with ProGP-4 results in increases in the number of WBC and Class

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1205903f8d184d7782765295c60a228c
https://pubmed.ncbi.nlm.nih.gov/12503028

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Promegapoietin, a family of chimeric growth factors, supports megakaryocyte development through activation of IL-3 and c-Mpl ligand signaling pathways

Autor: Jean P. Favara, Larry E Kahn, Judith G. Giri, Michiko S Huynh, Minnerly John C, N.R. Staten, John P. McKearn, Parul D Doshi, Ned R. Siegel, Ann L. Abegg, Doreen Villani-Price, John Warren Thomas, Walter G. Smith, Lyle E. Pegg

Publikováno v: Experimental hematology. 29(10)

Objective The signaling pathways induced by promegapoietin (PMP), a family of chimeric growth factors that activate the human IL-3 and c-Mpl receptors, were investigated. Methods The biological activity of PMP was examined by receptor binding, cell p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58c858dc9b235ef28c06eb2515efd945
https://pubmed.ncbi.nlm.nih.gov/11602319

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Dendritic cells generated in vivo by a chimeric hematopoietic growth factor, progenipoietin-4, demonstrate potent immunological function

Autor: Glenn Ishioka, Larry E Kahn, John Fikes, Carmen Gianfrani, Alessandro Sette, Robert W. Chesnut, Mingsheng Qin, Woulfe Susan L, Philip R Streeter

Publikováno v: Vaccine 19 (2001): 3710–3719.
info:cnr-pdr/source/autori:Ishioka GY, Fikes J, Qin M, Gianfrani C, Chesnut RW, Kahn LE, Streeter PR, Woulfe SL, Sette A./titolo:Dendritic cells generated in vivo by a chimeric hematopoietic growth factor, progenipoietin-4, demonstrate potent immunological function./doi:/rivista:Vaccine/anno:2001/pagina_da:3710/pagina_a:3719/intervallo_pagine:3710–3719/volume:19

Recently, a dual receptor agonist for human Flt3 and G-CSF receptors, progenipoietin-4 (ProGP-4), was shown to be highly effective in expanding DC in vivo. In this study, we examined the immunological activity of ProGP-4-generated dendritic cell (DC)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa45c82352cfee0f9ab1153468d567ea
https://pubmed.ncbi.nlm.nih.gov/11395205

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Megakaryocyte ex vivo expansion potential of three hematopoietic sources in serum and serum-free medium

Autor: Isaac Cohen, Larry E. Kahn, Jane N. Winter, Phil Lefebvre, Judith G. Giri

Publikováno v: Journal of hematotherapy. 8(2)

Megakaryocytes (MK) were expanded from purified human CD34+ cells obtained from three sources, bone marrow (BM), mobilized peripheral blood progenitor cells (PB), and umbilical cord (UC) blood. CD34+-selected cells were cultured for 12 days with 10 n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90fed4aeadc9e13805e6045914adde6e
https://pubmed.ncbi.nlm.nih.gov/10349914

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Identification of a Mouse Anti-Rat IgE Monoclonal Antibody, 44.7b, Which Inhibits IgE Binding to RBL Cells

Autor: Larry E. Kahn, Bonita J. Rup

Publikováno v: International Archives of Allergy and Immunology. 89:387-393

We have identified a monoclonal antibody specific for rat IgE, 44.7b, which blocks binding of rat IgE to the mast cell-like line RBL. Other monoclonal anti-rat IgE antibodies (MARE1 and B5) did not inhibit IgE binding to these cells. Furthermore, 44.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea98c5722cb8f2edbb54b3fa6c4d634d
https://doi.org/10.1159/000234980

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