Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Larry E. Broome"'
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Abstract P1-10-06: Effect of aging and mTOR inhibition on human mammary stem cells and early breast cancer progression markers
Autor: Larry E Broome, Hakim Bouamar, Kate Lathrop, Ismail Jatoi, Andrew Brenner, Michael Garcia, Alia Nazarullah, Karla Moncada, Virginia Kaklamani, Lu-Zhe Sun
Publikováno v: Cancer Research. 82:P1-10
Ductal carcinoma in situ (DCIS) is the most common form of breast cancer and is a predecessor to invasive carcinoma development. The origins for early breast cancer have been attributed to aberrant single cells, which may include adult stem and proge
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6664b189e5c870e4b810ee9fca599c9b
https://doi.org/10.1158/1538-7445.sabcs21-p1-10-06
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3
Data from Everolimus Inhibits the Progression of Ductal Carcinoma In Situ to Invasive Breast Cancer Via Downregulation of MMP9 Expression
Autor: Lu-Zhe Sun, Ismail Jatoi, Virginia Kaklamani, Andrew J. Brenner, Alia Nazarullah, Larry E. Broome, Guixi Zheng, Bingzhi Wang, Hakim Bouamar, Kyle Pressley, Xiao-Fei Ding, Guang Chen
Purpose:We evaluated the role of everolimus in the prevention of ductal carcinoma in situ (DCIS) to invasive ductal carcinoma (IDC) progression.Experimental Design:The effects of everolimus on breast cancer cell invasion, DCIS formation, and DCIS pro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ea154f99cde8044fcdbfbaa184c24f2
https://doi.org/10.1158/1078-0432.c.6530177.v1
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4
Figure S1 from Everolimus Inhibits the Progression of Ductal Carcinoma In Situ to Invasive Breast Cancer Via Downregulation of MMP9 Expression
Autor: Lu-Zhe Sun, Ismail Jatoi, Virginia Kaklamani, Andrew J. Brenner, Alia Nazarullah, Larry E. Broome, Guixi Zheng, Bingzhi Wang, Hakim Bouamar, Kyle Pressley, Xiao-Fei Ding, Guang Chen
mTOR inhibition decreases MMP9 expression. A, Everolimus treatment for 24 hours did not reduced MMP2 protein levels in SUM225 cells. B, C and D figures were the MMP-9 IHC quantification data measuring average optical density using ImageJ d 1.47 softw
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07378b542143c61f00d9ed1e7f777e07
https://doi.org/10.1158/1078-0432.22479284
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5
Abstract PS14-17: Rapamycin inhibits stem cell function and diminishes inflammation and senescence markers in human mammary gland
Autor: Lu-Zhe Sun, Larry E. Broome, Virginia G. Kaklamani, Alia Nazarullah, Ismail Jatoi, Andrew Brenner, Xiang Gu, Hakim Bouamar
Publikováno v: Cancer Research. 81:PS14-17
Gene expression profiles of some subtypes of breast cancer were shown to correspond to the profiles of the basal or luminal mammary stem/progenitor cell-enriched epithelial cells implicating the mammary stem cells (MaSCs) as tumor-initiating cells fo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9f7090e41bc78a4b5df6551caec596de
https://doi.org/10.1158/1538-7445.sabcs20-ps14-17
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6
Everolimus Inhibits the Progression of Ductal Carcinoma In Situ to Invasive Breast Cancer Via Downregulation of MMP9 Expression
Autor: Virginia G. Kaklamani, Alia Nazarullah, Hakim Bouamar, Andrew Brenner, Kyle Pressley, Lu-Zhe Sun, Xiao Fei Ding, Guang Chen, Bingzhi Wang, Guixi Zheng, Ismail Jatoi, Larry E. Broome
Publikováno v: Clinical Cancer Research. 26:1486-1496
Purpose: We evaluated the role of everolimus in the prevention of ductal carcinoma in situ (DCIS) to invasive ductal carcinoma (IDC) progression. Experimental Design: The effects of everolimus on breast cancer cell invasion, DCIS formation, and DCIS
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::978b73db640bc83b569ed57567a3ea7c
https://doi.org/10.1158/1078-0432.ccr-19-2478
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7
Abstract PS16-18: Inhibition of mTOR signaling by rapamycin abrogates mammary stem/progenitor cell activity in aged mice
Autor: James F. Nelson, Lu-Zhe Sun, Larry E. Broome, Hakim Bouamar
Publikováno v: Cancer Research. 81:PS16-18
Previous studies have shown an altered physiology in the mammary gland of aged mice, with mammary ducts displaying increased tertiary branching along with an enriched myoepithelial population compared to younger mice. It is the population of myoepith
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4b6162db5493dd71eeabeddfcdf40b84
https://doi.org/10.1158/1538-7445.sabcs20-ps16-18
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8
Mammary stem cells and their niche during aging
Autor: Lu-Zhe Sun, Larry E. Broome, Hakim Bouamar
Publikováno v: The Stem Cell Niche during Ageing ISBN: 9780128220191
The mammary gland is unique in that its development is primarily completed during puberty making the postnatal mammary stem cells responsible for both development and homeostasis, as well as reproductive functions in the adult mammal. In order to res
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8a1bf1a8d301fa0973d1bba151147af6
https://doi.org/10.1016/bs.asn.2020.05.003
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9
Everolimus Inhibits the Progression of Ductal Carcinoma
Autor: Guang, Chen, Xiao-Fei, Ding, Kyle, Pressley, Hakim, Bouamar, Bingzhi, Wang, Guixi, Zheng, Larry E, Broome, Alia, Nazarullah, Andrew J, Brenner, Virginia, Kaklamani, Ismail, Jatoi, Lu-Zhe, Sun
Publikováno v: Clin Cancer Res
PURPOSE: We evaluated the role of everolimus in the prevention of ductal carcinoma in situ (DCIS) to invasive ductal carcinoma (IDC) progression. EXPERIMENTAL DESIGN: The effects of everolimus on breast cancer cell invasion, DCIS formation, and DCIS
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2567e76237b3edd23b6652b32892103b
https://pubmed.ncbi.nlm.nih.gov/31871301
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