Výsledky vyhledávání - "Larry D. Altstiel"

Assessment of Azeliragon QTc Liability Through Integrated, Model‐Based Concentration QTc Analysis

Autor: Scott J. Brantley, Aaron H. Burstein, Larry D. Altstiel, Virginia D. Schmith, Imogene Dunn

Publikováno v: Clinical Pharmacology in Drug Development. 8:426-435

Azeliragon is an inhibitor of the receptor for advanced glycation end products being developed for the treatment of Alzheimer's disease. The objective of the current analysis was to evaluate the relationship between plasma azeliragon concentrations a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5344041863526549bc7b6456bf5ac507
https://doi.org/10.1002/cpdd.689

Zobrazit plný text záznamu

Plný text ve formátu HTML

[P1–066]: ASSESSMENT OF AZELIRAGON QTC LIABILITY THROUGH INTEGRATED, MODEL‐BASED CONCENTRATION QTC ANALYSIS

Autor: Imogene Dunn, Larry D. Altstiel, Virginia D. Schmith, Aaron H. Burstein, Scott J. Brantley

Publikováno v: Alzheimer's & Dementia. 13

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7b4f4ea26b270b033fb0ce0772d1cfcd
https://doi.org/10.1016/j.jalz.2017.06.133

Zobrazit plný text záznamu

A Multicenter, Double-Blind, Placebo-Controlled Trial of the PDE9A Inhibitor, PF-04447943, in Alzheimer’s Disease

Autor: Larry D. Altstiel, Clare B. Billing, Wendy Davidson, Elias Schwam, Robert Chew, Timothy Nicholas, Darlene Ambrose

Publikováno v: Current Alzheimer Research. 11:413-421

Background: PF-04447943 is a potent, selective phosphodiesterase 9A (PDE9A) inhibitor that elevates guanoscine 3’,5’ – cyclic monophosphate (cGMP) in brain and cerebrospinal fluid. PDE9A inhibition enhances synaptic plasticity and improves memo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fac050956a2e6af6835e3d152787ed80
https://doi.org/10.2174/1567205011666140505100858

Zobrazit plný text záznamu

Association of HLA class II alleles in patients with juvenile myoclonic epilepsy compared with patients with other forms of adolescent-onset generalized epilepsy

Autor: Xinping Yang, David A. Greenberg, Elisa Dicker, David S. Rosenbaum, Stanley R. Resor, Larry D. Altstiel, Irene Klotz, Mehdi Keddache, Shlomo Shinnar, Martina Durner, Gulian Zhou

Publikováno v: Neurology. 47:750-755

Reports have suggested an association of juvenile myoclonic epilepsy (JME) with an HLA-DR allele. We examined the HLA-DR and DQ frequencies in two populations of epilepsy patients: (1) JME patients and (2) patients with other forms of adolescent-onse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::880b91b2282dae59a1a32bcdda256a46
https://doi.org/10.1212/wnl.47.3.750

Zobrazit plný text záznamu

Evidence of a locus for schizophrenia and related disorders on the short arm of chromosome 5 in a large pedigree

Autor: Xin Ping Yang, Medhi Kedache, Michele Zaccario, Christopher J. Smith, Larry J. Siever, Tovah E. Hollander, Guilan Zhou, David A. Greenberg, Larry D. Altstiel, Richard C. Mohs, Jeremy M. Silverman, Kenneth L. Davis, Ge Li

Publikováno v: American Journal of Medical Genetics. 67:162-171

We attempted to identify a locus for schizophrenia and related disorders in 24 nuclear families of schizophrenic probands using a predefined classification system for affected cases that included those disorders most clearly identified as sharing a g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b61fe665391396bec75a5df6771f6199
https://doi.org/10.1002/(sici)1096-8628(19960409)67:2<162::aid-ajmg6>3.0.co

Zobrazit plný text záznamu

Apolipoprotein E-η4 allele and familial risk in Alzheimer's disease

Autor: Dushyant P. Purohit, Vahram Haroutunian, Daniel P. Perl, Larry D. Altstiel, Melinda Lantz, Richard C. Mohs, Jeremy M. Silverman, Kenneth L. Davis, Ge Li, Sandra Birstein

Publikováno v: Genetic Epidemiology. 13:285-298

Recent studies have found an association between presence of apolipoprotein E (APOE) epsilon 4 allele and Alzheimer's disease (AD). The present study compared the cumulative risk of primary progressive dementia (PPD) in relatives of AD probands carry

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b2be7485b80043a57b5f6fbe60e77d41
https://doi.org/10.1002/(sici)1098-2272(1996)13:3<285::aid-gepi5>3.0.co

Zobrazit plný text záznamu

Elevated Alpha1-Antichymotrypsin Serum Levels in a Subset of Nondemented First-Degree Relatives of Alzheimer's Disease Patients

Autor: James Schmeidler, Larry D. Altstiel, Brian A. Lawlor, Arthur Dalton, Richard C. Mohs, Kenneth L. Davis, Pankesh Mehta

Publikováno v: Dementia and Geriatric Cognitive Disorders. 6:17-20

A portion of Alzheimer''s disease (AD) patients have elevated serum levels of the acute phase reactant α1-antichymotrypsin (A1ACT) compared to age-matched controls. We measured serum levels of A1ACT in AD patients, age-matched controls, Down''s Synd

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5608776ea7d8630302aa47c7593048ce
https://doi.org/10.1159/000106917

Zobrazit plný text záznamu

Interaction of integral membrane proteins with multivalent ligands

Autor: Larry D. Altstiel, Frank R. Landsberger

Publikováno v: Biophysical journal. 37(1)

Enveloped viruses such as influenza, parainfluenza, and rhabdoviruses assemble by budding at the plasma membrane (1-3). During this process they acquire an envelope which has a lipid bilayer, whose composition reflects that of the host plasma membran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f97c810a2059858142baf8be6edb7fdd
https://pubmed.ncbi.nlm.nih.gov/19431509

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání