Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Larry C. Wienkers"'
Autor:
DAN A. ROCK, LARRY C. WIENKERS
Publikováno v:
Drug Metabolism Handbook. :465-526
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa0339309bfb456f533e844cf8763893
https://doi.org/10.1002/9781119851042.ch15
https://doi.org/10.1002/9781119851042.ch15
Autor:
John T Barr, Henry J Wienkers, Brooke M. Rock, Zhican Wang, Dan A. Rock, Larry C. Wienkers, Xiaoshan Min
Publikováno v:
Drug Metabolism and Disposition. 48:508-514
Experiments designed to identify the mechanism of cytochrome P450 inactivation are critical to drug discovery. Small molecules irreversibly inhibit P450 enzymatic activity via two primary mechanisms: apoprotein adduct formation or heme modification.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee45a877b4b2b24541954c1b9c51f60b
https://doi.org/10.1124/dmd.119.089813
https://doi.org/10.1124/dmd.119.089813
Overcoming Obstacles in Drug Discovery and Development uses real-world case studies to illustrate how critical thinking and problem solving skills are applied in the discovery and development of drugs. It also shows how developing critical thinking t
Publikováno v:
Handbook of Drug Metabolism ISBN: 9780429190315
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c972431ebaf444cf4cd464955ce96b70
https://doi.org/10.1201/9780429190315-19
https://doi.org/10.1201/9780429190315-19
Autor:
Paul G. Pearson, Larry C. Wienkers
This book continues to be the definitive reference on drug metabolism with an emphasis on new scientific and regulatory developments. It has been updated based on developments that have occurred in the last 5 years, with new chapters on large molecul
Autor:
Larry C. Wienkers, Jan L. Wahlstrom
Publikováno v:
Drug Discovery and Evaluation: Methods in Clinical Pharmacology ISBN: 9783319566375
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d809e45e378bfafdb0ad16f607e85b25
https://doi.org/10.1007/978-3-319-56637-5_14-1
https://doi.org/10.1007/978-3-319-56637-5_14-1
Publikováno v:
Molecular Pharmacology. 86:665-674
Ritonavir is a human immunodeficiency virus (HIV) protease inhibitor and an inhibitor of cytochrome P450 3A4, the major human hepatic drug-metabolizing enzyme. Given the potent inhibition of CYP3A4 by ritonavir, subtherapeutic doses of ritonavir are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b64a77825f4e7479e65956271e1d75ec
https://doi.org/10.1124/mol.114.094862
https://doi.org/10.1124/mol.114.094862
Publikováno v:
Drug Metabolism and Disposition. 42:1698-1707
Cytochrome P450 4F12 is a drug-metabolizing enzyme that is primarily expressed in the liver, kidney, colon, small intestine, and heart. The properties of CYP4F12 that may impart an increased catalytic selectivity (decreased promiscuity) were explored
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6ad321d1a626807b59a8e20426f7fc2
https://doi.org/10.1124/dmd.114.059626
https://doi.org/10.1124/dmd.114.059626
Autor:
Leslie J. Dickmann, Camille M. Konopnicki, Robert H. Tukey, Larry C. Wienkers, Jeffrey M. Tracy, Robert S. Foti
Publikováno v:
Archives of Biochemistry and Biophysics. 535:143-149
Previous experiments performed in recombinant systems have suggested that protein–protein interactions occur between the UGTs and may play a significant role in modulating enzyme activity. However, evidence of UGT protein–protein interactions eit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efadbd679a90f20d33eec1031fc0932b
https://doi.org/10.1016/j.abb.2013.03.012
https://doi.org/10.1016/j.abb.2013.03.012
Publikováno v:
Journal of Immunological Methods. 393:70-73
Bioanalytical support of discovery programs for human monoclonal antibody therapies involves quantitation by immunoassay. Historically, preclinical samples have been analyzed by the traditional Enzyme-Linked Immuno-Sorbent Assay (ELISA). We investiga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0ba6f458015d6b822d5f84ddc03b44c
https://doi.org/10.1016/j.jim.2013.03.011
https://doi.org/10.1016/j.jim.2013.03.011