Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Larry C. Schmued"'
Publikováno v:
Toxins, Vol 6, Iss 4, Pp 1453-1470 (2014)
Neuronal and vascular brain components are interrelated morphologically, physiologically and developmentally. Due to this close interrelationship, it is often difficult to understand the cause and effect relationship between neuronal vs. vascular dys
Externí odkaz:
https://doaj.org/article/c6e3af8f0a3b4e5aa0575056d1def0f0
Publikováno v:
Current Alzheimer Research
Background:Various methodologies have been employed for the localization of amyloid plaques in numerous studies on Alzheimer’s disease. The majority of these stains are thought to label the plaques by virtue of their affinity for aggregated Aβ. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::563ee941463ff7d3a133760181da17ff
https://doi.org/10.2174/1567205016666190725155038
https://doi.org/10.2174/1567205016666190725155038
Autor:
Debomoy K. Lahiri, Larry C. Schmued, Merle G. Paule, James Raymick, Sumit Sarkar, Balmiki Ray
Publikováno v:
Current Alzheimer Research. 12:837-846
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the fourth leading cause of death in the United States and most common cause of adult-onset dementia. The major hallmarks of AD are the formation of senile amyloid plaques made
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6ac36beec1e97de96c31857b59d1a24
https://doi.org/10.2174/156720501209151019105647
https://doi.org/10.2174/156720501209151019105647
Autor:
Merle G. Paule, Yi Hong Zhang, Ashlee Bell-Cohen, Melanie Dumas, Sumit Sarkar, Debomoy K. Lahiri, Larry C. Schmued, James Raymick, Dushyant Mann
Publikováno v:
Current Alzheimer Research. 11:299-308
Alzheimer’s disease (AD) is the most common age related human neurodegenerative disorder. The major histopathological characteristics of the AD brain are extracellular amyloid-beta (Aβ ) peptide loaded plaques and intraneuronal neurofibrillary tan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81d706340d81ff42b57cf846bab53c18
https://doi.org/10.2174/1567205011666140220125324
https://doi.org/10.2174/1567205011666140220125324
Autor:
John F. Bowyer, Dushyant Mann, Sumit Sarkar, Larry C. Schmued, James Raymick, Srinivasulu Chigurupati, Joseph P. Hanig, Merle G. Paule
Publikováno v:
Current Neurovascular Research. 11:48-61
Although selective neurodegeneration of nigro-striatal dopaminergic neurons is widely accepted as a cause of Parkinson's disease (PD), the role of vascular components in the brain in PD pathology is not well understood. However, the neurodegeneration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b808616eebcec5e35fea51fbd736dd7
https://doi.org/10.2174/1567202610666131124234506
https://doi.org/10.2174/1567202610666131124234506
Autor:
Larry C. Schmued, James Raymick, Melanie Dumas, Debomoy K. Lahiri, Sumit Sarkar, Yi Hong Zhang, Balmiki Ray, David M. Holtzman
Publikováno v:
Current Alzheimer Research. 10:494-506
Alzheimer's disease (AD), the most common human neurodegenerative disease, is characterized pathologically by numerous deposits of amyloid plaques in the brain. Systemic administration of clioquinol (CQ) and inoculation with amyloid-beta42 (Aβ42) va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::845681240fdd45a0eb375865a8b2f5c0
https://doi.org/10.2174/1567205011310050005
https://doi.org/10.2174/1567205011310050005
Autor:
Larry C. Schmued, James Raymick
Publikováno v:
Journal of neuroscience methods. 279
The vast majority of fluorochromes are organic in nature and none of the few existing chelates have been applied as histological tracers for localizing brain anatomy and pathology. New method In this study we have developed and characterized a Europi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53d301d20e917d3310f830616a489d89
https://pubmed.ncbi.nlm.nih.gov/27939963
https://pubmed.ncbi.nlm.nih.gov/27939963
Autor:
Larry C. Schmued
Publikováno v:
Brain research. 1645
Original article abstract Fluoro-gold: a new fluorescent retrograde axonal tracer with numerous unique properties A new fluorescent dye, Fluoro-Gold, has been demonstrated to undergo retrograde axonal transport. Its properties include (1) intense flu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16769b7112c280f103b5374f43eef5f8
https://pubmed.ncbi.nlm.nih.gov/27155454
https://pubmed.ncbi.nlm.nih.gov/27155454
Autor:
Larry C. Schmued, Sumit Sarkar
Publikováno v:
Brain Research. 1352:239-247
Laminin is a glycoprotein component of the basement membrane and has been reported to be found in different areas of the nervous system including brain endothelial cells, Schwann cells and peripheral nerves. Although the in-vitro studies suggest that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd2c12339f07831abaf2d2a5ebaabd09
https://doi.org/10.1016/j.brainres.2010.07.011
https://doi.org/10.1016/j.brainres.2010.07.011
Autor:
Larry C. Schmued, Zbigniew Binienda, Matthew Cozart, David Heard, Merle G. Paule, John F. Bowyer
Publikováno v:
Brain Research. 1229:210-217
A novel gold phosphate complex called Black-Gold II with improved myelin staining properties has been developed. It differs from its predecessor, Black-Gold, in that it is highly water soluble at room temperature. This unique physical property confer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52b59f7cc47a037ef67fbe3647f75161
https://doi.org/10.1016/j.brainres.2008.06.129
https://doi.org/10.1016/j.brainres.2008.06.129