Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Larry C. Park"'
Autor:
Tuulia Huhtala, Pekka Poutiainen, Jussi Rytkönen, Kimmo Lehtimäki, Teija Parkkari, Iiris Kasanen, Anu J. Airaksinen, Teija Koivula, Patrick Sweeney, Outi Kontkanen, John Wityak, Celia Dominiquez, Larry C. Park
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 4, Iss 1, Pp 1-10 (2019)
Abstract Purpose Dopamine receptors are involved in pathophysiology of neuropsychiatric diseases, including Huntington’s disease (HD). PET imaging of dopamine D2 receptors (D2R) in HD patients has demonstrated 40% decrease in D2R binding in striatu
Externí odkaz:
https://doaj.org/article/a52816b954344ea281c1827d252cb4e4
Autor:
Tuukka O. Piiponniemi, Teija Parkkari, Taneli Heikkinen, Jukka Puoliväli, Larry C. Park, Roger Cachope, Maksym V. Kopanitsa
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 12 (2018)
Cognitive disturbances often predate characteristic motor dysfunction in individuals with Huntington’s disease (HD) and place an increasing burden on the HD patients and caregivers with the progression of the disorder. Therefore, application of max
Externí odkaz:
https://doaj.org/article/d214211a342943adb309c47625f378d5
Rapid and robust patterns of spontaneous locomotor deficits in mouse models of Huntington's disease.
Autor:
Taneli Heikkinen, Timo Bragge, Niina Bhattarai, Teija Parkkari, Jukka Puoliväli, Outi Kontkanen, Patrick Sweeney, Larry C Park, Ignacio Munoz-Sanjuan
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0243052 (2020)
Huntington's disease (HD) is an inherited neurodegenerative disorder characterized by severe disruption of cognitive and motor functions, including changes in posture and gait. A number of HD mouse models have been engineered that display behavioral
Externí odkaz:
https://doaj.org/article/07aa52b632ac417abd3cbd33a4065cef
Autor:
Nima N Naseri, Joseph Bonica, Hui Xu, Larry C Park, Jamshid Arjomand, Zhengming Chen, Gary E Gibson
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0160384 (2016)
Metabolic dysfunction is well-documented in Huntington's disease (HD). However, the link between the mutant huntingtin (mHTT) gene and the pathology is unknown. The tricarboxylic acid (TCA) cycle is the main metabolic pathway for the production of NA
Externí odkaz:
https://doaj.org/article/55ce99018e394d29bc1b712d904d5c15
Autor:
Liliana B Menalled, Andrea E Kudwa, Sam Miller, Jon Fitzpatrick, Judy Watson-Johnson, Nicole Keating, Melinda Ruiz, Richard Mushlin, William Alosio, Kristi McConnell, David Connor, Carol Murphy, Steve Oakeshott, Mei Kwan, Jose Beltran, Afshin Ghavami, Dani Brunner, Larry C Park, Sylvie Ramboz, David Howland
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e49838 (2012)
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder characterized by motor, cognitive and psychiatric manifestations. Since the mutation responsible for the disease was identified as an unstable expansion of CAG repeats in t
Externí odkaz:
https://doaj.org/article/7b9395c26cd34e0482a329a3cc5cbeb5
Autor:
Taneli Heikkinen, Kimmo Lehtimäki, Nina Vartiainen, Jukka Puoliväli, Susan J Hendricks, Jack R Glaser, Amyaouch Bradaia, Kristian Wadel, Chrystelle Touller, Outi Kontkanen, Juha M Yrjänheikki, Bruno Buisson, David Howland, Vahri Beaumont, Ignacio Munoz-Sanjuan, Larry C Park
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e50717 (2012)
Huntington's disease (HD) is an autosomal neurodegenerative disorder, characterized by severe behavioral, cognitive, and motor deficits. Since the discovery of the huntingtin gene (HTT) mutation that causes the disease, several mouse lines have been
Externí odkaz:
https://doaj.org/article/1175932203944c0d96212f3286b6ccdd