Výsledky vyhledávání - "Larry C. Blaszczak"

Autor: Larry C. Blaszczak, Scott C. Mauldin, Michael S. VanNieuwenhze, James Abraham Aikins, Mohammad Zia-Ebrahimi

Publikováno v: Journal of the American Chemical Society. 123:6983-6988

A total synthesis of lipid I (4), a membrane-associated intermediate in the bacterial cell wall (peptidoglycan) biosynthesis pathway, is reported. This highly convergent synthesis will enable further studies on bacterial resistance mechanisms and may

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26b76f3402d5cdd502d37b85769fe713
https://doi.org/10.1021/ja016082o

Zobrazit plný text záznamu

Crystal Structures of Substrate and Inhibitor Complexes with AmpC β-Lactamase: Possible Implications for Substrate-Assisted Catalysis

Autor: Brian K. Shoichet, Alexandra Patera, Larry C. Blaszczak

Publikováno v: Journal of the American Chemical Society. 122:10504-10512

Group I β-lactamases are major resistance determinants to β-lactam antibiotics. Despite intense study, the identity of the catalytic base, the direction of hydrolytic attack, and the functional difference between β-lactam substrates and β-lactam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::869083d85749733f854602af9ed4e899
https://doi.org/10.1021/ja001676x

Zobrazit plný text záznamu

Radical Rearrangement: A Strategy for Conversion of Cephalosporin to 1-Carba(dethia)cephalosporin

Autor: Douglas O. Spry, Brown Raymond Frank, Noreen G. Halligan, Larry C. Blaszczak

Publikováno v: Tetrahedron. 56:5679-5685

A radical rearrangement approach to semisynthesis of the carbacephem class of β-lactam antibiotics is reported. The crucial bond construction in assembly of the carbacephem framework was accomplished by intramolecular C–C bond formation between an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d5a3699a4070ee581a1fb225b6332695
https://doi.org/10.1016/s0040-4020(00)00417-8

Zobrazit plný text záznamu

BOCILLIN FL, a Sensitive and Commercially Available Reagent for Detection of Penicillin-Binding Proteins

Autor: Steven D. Kahl, Larry C. Blaszczak, Genshi Zhao, Kyle R. Gee, Timothy I. Meier

Publikováno v: Antimicrobial Agents and Chemotherapy. 43:1124-1128

Penicillin-binding proteins (PBPs) are the enzymes that are required for the biosynthesis of the bacterial cell wall (10, 11, 23, 31). PBPs catalyze the final steps of the polymerization (transglycosylation) and cross-linking (transpeptidation) of pe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51c60c917aa0f97d6d4cf64c3ba9f23a
https://doi.org/10.1128/aac.43.5.1124

Zobrazit plný text záznamu

Synthesis of new 3-thiosubstituted carbacephem antibiotics and their activity against penicillin resistant Streptococcus pneumoniae

Autor: Eid Clark Norman, J. E. Flokowitsch, David A. Preston, Mohammad Zia-Ebrahimi, Larry C. Blaszczak, Stephen A. Hitchcock, G. Stuart Gregory, Michael J. Nesler, George W. Huffman, Daniel Ray Mayhugh

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 7:2261-2264

The synthesis of a series of 3-thiosubstituted carbacephem derivatives is described. The compounds were assayed against penicillin susceptible, intermediate and resistant strains of Streptococcus pneumoniae. Several analogs displayed potent in vitro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::017c606fd98ea7bd7bf42c93451cf79d
https://doi.org/10.1016/s0960-894x(97)00412-5

Zobrazit plný text záznamu

Single Molecule Dynamics of Lysozyme Processing Distinguishes Linear and Cross-linked Peptidoglycan Substrates

Autor: Issa S. Moody, Patrick C. Sims, Gregory A. Weiss, Brad L. Corso, David E. Seitz, Steven R. Hunt, Larry C. Blaszczak, Philip G. Collins, Yongki Choi

The dynamic processivity of individual T4 lysozyme molecules was monitored in the presence of either linear or cross-linked peptidoglycan substrates. Single-molecule monitoring was accomplished using a novel electronic technique in which lysozyme mol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cde13b1b8c271fbd2d216804e2c308b6
https://europepmc.org/articles/PMC3271187/

Zobrazit plný text záznamu

Site-directed mutagenesis of the mecA gene from a methicillin-resistant strain of Staphylococcus aureus

Autor: C. Y. E. Wu, Paul L. Skatrud, Larry C. Blaszczak, Serhat Ünal, J. E. Flokowitsch, William E. Alborn, JoAnn Hoskins, David A. Preston

Publikováno v: Journal of Bacteriology. 176:443-449

The mecA-27r gene from Staphylococcus aureus 27r encodes penicillin-binding protein 2a (PBP2a-27r), which causes this strain to be methicillin resistant. Removal or replacement of the N-terminal transmembrane domain had no effect on binding of penici

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd8f912551c1d652a0c6e606db708726
https://doi.org/10.1128/jb.176.2.443-449.1994

Zobrazit plný text záznamu

Comparison of the in vivo and in vitro nuclear magnetic resonance detection of trifluoromethyl penicillin V in rats

Autor: Thomas R. Parr, Larry C. Blaszczak, S. Ramaprasad, G. Douglas Campbell, Keith M. Olsen, A. Francine Tryka, Richard A. Komoroski

Publikováno v: Journal of Pharmaceutical Sciences. 82:48-51

Fluorine nuclear magnetic resonance (NMR) spectroscopy and magnetic resonance imaging were examined as noninvasive methods for characterizing antibiotic disposition and pharmacokinetics in vivo. For determination of their utility, a 19 F surface coil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::418d4ea14d8e0f900cda201e355b1893
https://doi.org/10.1002/jps.2600820111

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání