Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Larry C. Blaszczak"'
Autor:
Larry C. Blaszczak, Scott C. Mauldin, Michael S. VanNieuwenhze, James Abraham Aikins, Mohammad Zia-Ebrahimi
Publikováno v:
Journal of the American Chemical Society. 123:6983-6988
A total synthesis of lipid I (4), a membrane-associated intermediate in the bacterial cell wall (peptidoglycan) biosynthesis pathway, is reported. This highly convergent synthesis will enable further studies on bacterial resistance mechanisms and may
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26b76f3402d5cdd502d37b85769fe713
https://doi.org/10.1021/ja016082o
https://doi.org/10.1021/ja016082o
Publikováno v:
Journal of the American Chemical Society. 122:10504-10512
Group I β-lactamases are major resistance determinants to β-lactam antibiotics. Despite intense study, the identity of the catalytic base, the direction of hydrolytic attack, and the functional difference between β-lactam substrates and β-lactam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::869083d85749733f854602af9ed4e899
https://doi.org/10.1021/ja001676x
https://doi.org/10.1021/ja001676x
Publikováno v:
Tetrahedron. 56:5679-5685
A radical rearrangement approach to semisynthesis of the carbacephem class of β-lactam antibiotics is reported. The crucial bond construction in assembly of the carbacephem framework was accomplished by intramolecular C–C bond formation between an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5a3699a4070ee581a1fb225b6332695
https://doi.org/10.1016/s0040-4020(00)00417-8
https://doi.org/10.1016/s0040-4020(00)00417-8
Publikováno v:
Antimicrobial Agents and Chemotherapy. 43:1124-1128
Penicillin-binding proteins (PBPs) are the enzymes that are required for the biosynthesis of the bacterial cell wall (10, 11, 23, 31). PBPs catalyze the final steps of the polymerization (transglycosylation) and cross-linking (transpeptidation) of pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51c60c917aa0f97d6d4cf64c3ba9f23a
https://doi.org/10.1128/aac.43.5.1124
https://doi.org/10.1128/aac.43.5.1124
Autor:
Eid Clark Norman, J. E. Flokowitsch, David A. Preston, Mohammad Zia-Ebrahimi, Larry C. Blaszczak, Stephen A. Hitchcock, G. Stuart Gregory, Michael J. Nesler, George W. Huffman, Daniel Ray Mayhugh
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:2261-2264
The synthesis of a series of 3-thiosubstituted carbacephem derivatives is described. The compounds were assayed against penicillin susceptible, intermediate and resistant strains of Streptococcus pneumoniae. Several analogs displayed potent in vitro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::017c606fd98ea7bd7bf42c93451cf79d
https://doi.org/10.1016/s0960-894x(97)00412-5
https://doi.org/10.1016/s0960-894x(97)00412-5
Autor:
Issa S. Moody, Patrick C. Sims, Gregory A. Weiss, Brad L. Corso, David E. Seitz, Steven R. Hunt, Larry C. Blaszczak, Philip G. Collins, Yongki Choi
The dynamic processivity of individual T4 lysozyme molecules was monitored in the presence of either linear or cross-linked peptidoglycan substrates. Single-molecule monitoring was accomplished using a novel electronic technique in which lysozyme mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cde13b1b8c271fbd2d216804e2c308b6
https://europepmc.org/articles/PMC3271187/
https://europepmc.org/articles/PMC3271187/
Autor:
C. Y. E. Wu, Paul L. Skatrud, Larry C. Blaszczak, Serhat Ünal, J. E. Flokowitsch, William E. Alborn, JoAnn Hoskins, David A. Preston
Publikováno v:
Journal of Bacteriology. 176:443-449
The mecA-27r gene from Staphylococcus aureus 27r encodes penicillin-binding protein 2a (PBP2a-27r), which causes this strain to be methicillin resistant. Removal or replacement of the N-terminal transmembrane domain had no effect on binding of penici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd8f912551c1d652a0c6e606db708726
https://doi.org/10.1128/jb.176.2.443-449.1994
https://doi.org/10.1128/jb.176.2.443-449.1994
Autor:
Thomas R. Parr, Larry C. Blaszczak, S. Ramaprasad, G. Douglas Campbell, Keith M. Olsen, A. Francine Tryka, Richard A. Komoroski
Publikováno v:
Journal of Pharmaceutical Sciences. 82:48-51
Fluorine nuclear magnetic resonance (NMR) spectroscopy and magnetic resonance imaging were examined as noninvasive methods for characterizing antibiotic disposition and pharmacokinetics in vivo. For determination of their utility, a 19 F surface coil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::418d4ea14d8e0f900cda201e355b1893
https://doi.org/10.1002/jps.2600820111
https://doi.org/10.1002/jps.2600820111
Publikováno v:
ChemInform. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53d28d449a59ae0becd9c9efe4e4ecae
https://doi.org/10.1002/chin.199137144
https://doi.org/10.1002/chin.199137144
Autor:
George W. Huffman, Mohammad Zia-Ebrahimi, George Stuart Gregory, David A. Preston, Daniel Ray Mayhugh, Eid Clark Norman, Larry C. Blaszczak, J. E. Flokowitsch, Stephen A. Hitchcock, Michael J. Nesler
Publikováno v:
ChemInform. 28
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af8791602483f165a565b0c976c371a1
https://doi.org/10.1002/chin.199752258
https://doi.org/10.1002/chin.199752258