Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Larry A Couture"'
Autor:
Pradip Bajgain, Roopa Mucharla, John Wilson, Dan Welch, Usanarat Anurathapan, Bitao Liang, Xiaohua Lu, Kyle Ripple, John M Centanni, Christine Hall, David Hsu, Larry A Couture, Shubhranshu Gupta, Adrian P Gee, Helen E Heslop, Ann M Leen, Cliona M Rooney, Juan F Vera
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 1, Iss C (2014)
Broader implementation of cell-based therapies has been hindered by the logistics associated with the expansion of clinically relevant cell numbers ex vivo. To overcome this limitation, Wilson Wolf Manufacturing developed the G-Rex, a cell culture fl
Externí odkaz:
https://doaj.org/article/d53190c4394a4fa6b235fead97660163
Publikováno v:
Cell Therapy ISBN: 9783030755355
Cell Therapy
Cell Therapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e1f07188db041169414a0a7afd08194
https://doi.org/10.1007/978-3-030-75537-9_16
https://doi.org/10.1007/978-3-030-75537-9_16
Autor:
Lil Pabon, Stephanie A. Tuck, Audrey Baldessari, Dale W. Hailey, Keith W. Vogel, Zachary L. Steinberg, Faith A. Kalucki, Stephen P. Seslar, Billy Chen, Hiroshi Tsuchida, Jason Ogle, W. Robb MacLellan, Akiko Futakuchi-Tsuchida, Milly S. Lyu, R. Scott Thies, Charles E. Murry, Yen Wen Liu, Larry A. Couture, Hans Reinecke, Xiulan Yang, Sarah K. Dupras, Anna V. Naumova, Benjamin H. Fryer, Creighton W. Don, James Chun-I Lee, Clifford A. Astley, James A. Fugate
Publikováno v:
Nature Biotechnology. 36:597-605
Pluripotent stem cell-derived cardiomyocyte grafts can remuscularize substantial amounts of infarcted myocardium and beat in synchrony with the heart, but in some settings cause ventricular arrhythmias. It is unknown whether human cardiomyocytes can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d6f0b67741d0bab8748407b6bd4db67
https://doi.org/10.1038/nbt.4162
https://doi.org/10.1038/nbt.4162
Autor:
Evangeline Tzatzalos, Larry A. Couture, Tony Chour, Elena Matsa, Joseph D. Gold, Paul W. Burridge, Yan Zhuge, Gwanghyun Jung, Ellen Kuhl, Huaxiao Yang, Johannes Riegler, Vincent C. Chen, Praveen K. Shukla, Ioannis Karakikes, Malte Tiburcy, Wolfram H. Zimmermann, Oscar J. Abilez, Daniel Bernstein, Alexander M. Zöllner, Joseph C. Wu, Ming-Tao Zhao
Publikováno v:
Stem Cells. 36:265-277
The ability to differentiate human pluripotent stem cells (hPSCs) into cardiomyocytes (CMs) makes them an attractive source for repairing injured myocardium, disease modeling, and drug testing. Although current differentiation protocols yield hPSC-CM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a4ed009c7c3efb382955f00c7fc2751
https://doi.org/10.1002/stem.2732
https://doi.org/10.1002/stem.2732
Autor:
Marc Jung, David Hsu, Swetha Godatha, Elizabeth Lizhar, Xiwei Wu, Jingjing Ye, Larry A. Couture, Joshua D. Tompkins, Arthur D. Riggs, Chang yi Chen, Ziguang Lin
Publikováno v:
EBioMedicine
EBioMedicine, Vol 4, Iss C, Pp 74-85 (2016)
EBioMedicine, Vol 4, Iss C, Pp 74-85 (2016)
The directed differentiation of human cardiomyocytes (CMs) from pluripotent cells provides an invaluable model for understanding mechanisms of cell fate determination and offers considerable promise in cardiac regenerative medicine. Here, we utilize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d19db9eb15fed97ab92feb8b63c5be1
https://doi.org/10.1016/j.ebiom.2016.01.021
https://doi.org/10.1016/j.ebiom.2016.01.021
Autor:
Joseph C. Wu, Praveen K. Shukla, Joseph D. Gold, David Hsu, Larry A. Couture, Jian-Chang Liu, Jing Chai, Danlin Chen, Vincent C. Chen, Giau Hua, Ziguang Lin, Jingjing Ye
Publikováno v:
Stem Cell Research, Vol 15, Iss 2, Pp 365-375 (2015)
To meet the need of a large quantity of hPSC-derived cardiomyocytes (CM) for pre-clinical and clinical studies, a robust and scalable differentiation system for CM production is essential. With a human pluripotent stem cells (hPSC) aggregate suspensi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1ad2439536f4a1b79812e0c1fd3b905
https://doi.org/10.1016/j.scr.2015.08.002
https://doi.org/10.1016/j.scr.2015.08.002
Autor:
Melissa K. Carpenter, Larry A. Couture
Publikováno v:
Stem Cells Translational Medicine. 4:1097-1100
Summary Several human embryonic stem cell (hESC)-derived cell therapeutics have entered clinical testing and more are in various stages of preclinical development. The U.S. Food and Drug Administration (FDA) regulates these products under existing re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fa8335e0603530f391d096b67ea4314
https://doi.org/10.5966/sctm.2015-0045
https://doi.org/10.5966/sctm.2015-0045
Publikováno v:
Journal of Clinical Investigation. 125:2551-2557
Human pluripotent stem cells are known to have the capacity to renew indefinitely, being intrinsically able to differentiate into many different cell types. These characteristics have generated tremendous enthusiasm about the potential applications o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da6e6fbd1a5a01a091ffb7f3aea53d8e
https://doi.org/10.1172/jci80575
https://doi.org/10.1172/jci80575
Publikováno v:
Cardiac and Vascular Biology ISBN: 9783319561042
Establishment of a scalable, robust, and GMP-compatible manufacturing process for human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) has been a bottleneck for the progress of cell therapy for heart diseases. The adherent cell culture platf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8533082671f3b5a30bca4f45346cf5fc
https://doi.org/10.1007/978-3-319-56106-6_7
https://doi.org/10.1007/978-3-319-56106-6_7
Autor:
Cliona M. Rooney, Larry A. Couture, Robert Lindblad, David Styers, Peiman Hematti, Laarni Ibenana, Myriam Armant, Deborah Wood, David H. McKenna, John E. Wagner, Adrian P. Gee, Derek J. Hei, Lisbeth A. Welniak, Traci Heath Mondoro, Leslie E. Silberstein
Publikováno v:
Transfusion. 55:674-679
Cell therapy products have become more sophisticated both in type and manufacturing complexity (1-3). As clinicians' and researchers' understanding of disease and cell mechanisms of action continue to grow, cell therapy products are being increasingl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84fdca325a806b448fcf8ce2ce24b66c
https://doi.org/10.1111/trf.12881
https://doi.org/10.1111/trf.12881