Zobrazeno 1 - 10
of 139
pro vyhledávání: '"Larry, Zeitlin"'
Autor:
Kohei Togami, Whitney Wolf, Lucas C. Olson, Madison Card, Limei Shen, Alison Schaefer, Kenichi Okuda, Larry Zeitlin, Michael Pauly, Kevin Whaley, Raymond J. Pickles, Samuel K. Lai
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Effective treatment and immunoprophylaxis of viral respiratory infections with neutralizing monoclonal antibodies (mAbs) require maintaining inhibitory concentrations of mAbs at the airway surface. While engineered mAbs with increased affinity to the
Externí odkaz:
https://doaj.org/article/1ce0586831914fc7af05bae7e4c1ab5f
Autor:
Alison Schaefer, Bing Yang, Holly A. Schroeder, Dimple Harit, Mike S. Humphry, Larry Zeitlin, Kevin J. Whaley, Jacques Ravel, William A. Fischer, Samuel K. Lai
Publikováno v:
Emerging Microbes and Infections, Vol 13, Iss 1 (2024)
ABSTRACTVaginal transmission from semen of male Ebola virus (EBOV) survivors has been implicated as a potential origin of Ebola virus disease (EVD) outbreaks. While EBOV in semen must traverse cervicovaginal mucus (CVM) to reach target cells, the beh
Externí odkaz:
https://doaj.org/article/0b91368b024b4ae7a579ea704274de58
Autor:
Olivia S. Shin, Stephanie R. Monticelli, Christy K. Hjorth, Vladlena Hornet, Michael Doyle, Dafna Abelson, Ana I. Kuehne, Albert Wang, Russell R. Bakken, Akaash K. Mishra, Marissa Middlecamp, Elizabeth Champney, Lauran Stuart, Daniel P. Maurer, Jiannan Li, Jacob Berrigan, Jennifer Barajas, Stephen Balinandi, Julius J. Lutwama, Leslie Lobel, Larry Zeitlin, Laura M. Walker, John M. Dye, Kartik Chandran, Andrew S. Herbert, Noel T. Pauli, Jason S. McLellan
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114502- (2024)
Summary: Crimean-Congo hemorrhagic fever virus can cause lethal disease in humans yet there are no approved medical countermeasures. Viral glycoprotein GP38, exclusive to Nairoviridae, is a target of protective antibodies and is a key antigen in prec
Externí odkaz:
https://doaj.org/article/d783005edd1a4330be69737cbfd33c17
Autor:
Emilie Mausser, Ellena Nador, Joseph A Politch, Michael R Pauly, Jai G Marathe, Thomas R Moench, Larry Zeitlin, Kevin J Whaley, Deborah J Anderson
Publikováno v:
PLoS ONE, Vol 18, Iss 3, p e0282147 (2023)
High rates of unintended pregnancies worldwide indicate a need for more accessible and acceptable methods of contraception. We have developed a monoclonal antibody, the Human Contraception Antibody (HCA), for use by women in vaginal films and rings f
Externí odkaz:
https://doaj.org/article/be5acf215cfe4c2b96bdb4513195bae6
Autor:
Krista Meserve, Abraham J. Qavi, M. Javad Aman, Hong Vu, Larry Zeitlin, John M. Dye, Jeffrey W. Froude, Daisy W. Leung, Lan Yang, Frederick W. Holtsberg, Gaya K. Amarasinghe, Ryan C. Bailey
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101719- (2022)
Summary: This protocol describes the use of silicon photonic microring resonator sensors for detection of Ebola virus (EBOV) and Sudan virus (SUDV) soluble glycoprotein (sGP). This protocol encompasses biosensor functionalization of silicon microring
Externí odkaz:
https://doaj.org/article/e9bbcc7f59114f908957058b53e324a5
Autor:
Kelsi Swope, Josh Morton, Gregory P. Pogue, Leigh Burden, Nicholas Partain, Steve Hume, John Shepherd, Carrie A. Simpson, Miles B. Brennan, Thomas C. Furman, Sheila Kingrey-Gebe, Theresa Martinez, Jim McDonough, Michael H. Pauly, Kevin J. Whaley, Larry Zeitlin, Barry Bratcher, Hugh Haydon
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
The ongoing SARS-CoV-2 coronavirus pandemic of 2020–2021 underscores the need for manufacturing platforms that can rapidly produce monoclonal antibody (mAb) therapies. As reported here, a platform based on Nicotiana benthamiana produced mAb therape
Externí odkaz:
https://doaj.org/article/0444f122130744d095e196c092b78bd8
Autor:
Robert W. Cross, Zachary A. Bornholdt, Abhishek N. Prasad, Viktoriya Borisevich, Krystle N. Agans, Daniel J. Deer, Dafna M. Abelson, Do H. Kim, William S. Shestowsky, Lioudmila A. Campbell, Elaine Bunyan, Joan B. Geisbert, Karla A. Fenton, Larry Zeitlin, Danielle P. Porter, Thomas W. Geisbert
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Extending the therapeutic window for acute viral infections could save lives. Here, the authors show that combination treatment with a human monoclonal antibody and remdesivir initiated at 6 days post infection with Marburg virus provides 80% protect
Externí odkaz:
https://doaj.org/article/d0f0bff00c684416a81ac789aecee0a8
Autor:
Robert W. Cross, Zachary A. Bornholdt, Abhishek N. Prasad, Courtney Woolsey, Viktoriya Borisevich, Krystle N. Agans, Daniel J. Deer, Dafna M. Abelson, Do H. Kim, William S. Shestowsky, Lioudmila A. Campbell, Elaine Bunyan, Joan B. Geisbert, Natalie S. Dobias, Karla A. Fenton, Danielle P. Porter, Larry Zeitlin, Thomas W. Geisbert
Publikováno v:
JCI Insight, Vol 7, Iss 10 (2022)
A major challenge in managing acute viral infections is ameliorating disease when treatment is delayed. Previously, we reported the success of a 2-pronged mAb and antiviral remdesivir therapeutic approach to treat advanced illness in rhesus monkeys i
Externí odkaz:
https://doaj.org/article/c92d002b9f334e558178cd3717ce240a
Autor:
Larry Zeitlin, Richard A. Cone
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 18, Iss 2 (2022)
Externí odkaz:
https://doaj.org/article/4063c716188b46af8d1da10105b9fda0
Autor:
Kevin J Whaley, Larry Zeitlin
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 18, Iss 2 (2022)
This review focuses on the emerging monoclonal antibody market for infectious diseases and the metric ton scale manufacturing requirements to meet global demand. Increasing access to existing antibody-based products coupled with the unmet need in inf
Externí odkaz:
https://doaj.org/article/18e705d77c1c49f3b407847b94f3f1b6