Výsledky vyhledávání - "Larry, Brieaddy"

α-[Amino(4-aminophenyl)thio]methylene-2-(trifluoromethyl)benzeneacetonitrile; Configurational Equilibria in Solution

Autor: Herbert H. Seltzman, Jeffrey R. Deschamps, P. Anantha Reddy, S. Wayne Mascarella, Anita H. Lewin, Larry Brieaddy, F. Ivy Carroll, Scott E. Fix, Charles J. McElhinny, Gregory H. Imler

Publikováno v: Bioorg Chem

Inconsistent results have been reported for the effects of the mitogen-activating extracellular kinase (MEK) inhibitor α-[amino(4-aminophenyl)thio]methylene-2-(trifluoromethyl)benzeneacetonitrile (SL 327) on ethanol-induced conditioned place prefere

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67a55f21d11bcceab0ad9b7d46b9c0e8
https://europepmc.org/articles/PMC8217309/

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Synthesis and Characterization of the Selective, Reversible PKCβ Inhibitor (9S)-9-[(Dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione, Ruboxistaurin (LY333531)

Autor: Jeffrey R. Deschamps, Gregory H. Imler, F. Ivy Carroll, Larry Brieaddy, S. Wayne Mascarella, P. Anantha Reddy, Anita H. Lewin

Publikováno v: ACS Chemical Neuroscience. 10:246-251

The demonstrated role of PKCβ in mediating amphetamine-stimulated dopamine efflux, which regulates amphetamine-induced dopamine transporter trafficking and activity, has promoted the research use of the selective, reversible PKCβ inhibitor (9 S)-9-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::75d406708f72cbb80407e81ea2bc150b
https://doi.org/10.1021/acschemneuro.8b00196

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Synthesis and Characterization of the Selective, Reversible PKC

Autor: Anita H, Lewin, Larry, Brieaddy, Jeffrey R, Deschamps, Gregory H, Imler, S Wayne, Mascarella, P Anantha, Reddy, F Ivy, Carroll

Publikováno v: ACS chemical neuroscience. 10(1)

The demonstrated role of PKC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f9cb512ea4d33b9f5c3e91a9ffc71f34
https://pubmed.ncbi.nlm.nih.gov/30156829

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Synthesis and In Vitro Opioid Receptor Functional Antagonism of Analogues of the Selective Kappa Opioid Receptor Antagonist (3R)-7-Hydroxy-N-((1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic)

Autor: Zhou Zou, Tingwei Bill Cai, Hernán A. Navarro, F. Ivy Carroll, James B. Thomas, Larry Brieaddy

Publikováno v: Journal of Medicinal Chemistry. 51:1849-1860

In previous structure–activity relationship (SAR) studies, we identified (3R)-7-hydroxy-N-((1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic, 1) as the first

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9bf3d85b1bfa1569094094e71c6819a7
https://doi.org/10.1021/jm701344b

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An Improved Synthesis of (3R)-2-(tert-Butoxycarbonyl)-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid

Autor: Larry Brieaddy, James B. Thomas, Bertold D. Berrang, Cong Liu, F. Ivy Carroll

Publikováno v: Synthesis. 2008:856-858

An improved synthesis of (3 R)-2-( TERT-butoxycarbonyl)-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid is described wherein a modified Pictet-Spengler reaction was employed to provide 95% yield of the product with 7% racemization or less.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2a0e9650d5b5c958b141233cac272c98
https://doi.org/10.1055/s-2008-1032211

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Synthesis and in vitro opioid receptor functional antagonism of analogues of the selective kappa opioid receptor antagonist (3R)-7-hydroxy-N-((1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic)

Autor: Tingwei Bill, Cai, Zhou, Zou, James B, Thomas, Larry, Brieaddy, Hernán A, Navarro, F Ivy, Carroll

Publikováno v: Journal of medicinal chemistry. 51(6)

In previous structure-activity relationship (SAR) studies, we identified (3 R)-7-hydroxy- N-((1 S)-1-{[(3 R,4 R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic, 1) as the fir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6fbab144a7c47b75c0b0fd81c004d050
https://pubmed.ncbi.nlm.nih.gov/18307295

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