Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Larocque James Paul"'
Autor:
Fabrizio Sitzia, Renza Roncarati, Thomas A. Comery, Brian Jow, Mark R. Bowlby, Dianne Kowal, Flora Jow, Adam M. Gilbert, Veronica Soloveva, Larocque James Paul, Tim Lock, Angela Kramer, John Dunlop, Andrew D. Randall, Steven M. Grauer, Jon T. Brown
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 328:766-776
The α7 nicotinic acetylcholine receptor (nAChR) has been implicated in Alzheimer's disease and schizophrenia, leading to efforts targeted toward discovering agonists and positive allosteric modulators (PAMs) of this receptor. In a Ca2+ flux fluorome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fe2685986f3ba41e3b8e35698c9d34e
https://doi.org/10.1124/jpet.108.146514
https://doi.org/10.1124/jpet.108.146514
Autor:
Edward McKillip, Veronica Soloveva, John Michael Morin, Nicole Bracy-Johnson, Jeff Paslay, Larocque James Paul
Publikováno v:
BioProcessing Journal. 6:39-44
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::577b35a1a09ed2c5f423090c8c5299b0
https://doi.org/10.12665/j61.mckillip
https://doi.org/10.12665/j61.mckillip
Publikováno v:
JALA: Journal of the Association for Laboratory Automation. 11:145-156
Cell-based assays for identification of biologically active small molecules from chemical libraries are becoming increasingly popular for HTS aimed at a variety of drug targets. Functional assays require good coordination between several independent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::759aea208bf26783379be2802043a611
https://doi.org/10.1016/j.jala.2006.02.006
https://doi.org/10.1016/j.jala.2006.02.006
Autor:
Larocque James Paul, Adam Pitkin, Tammy Michelle Sadler, Maria Achilleos, Shoba Ragunathan, John Michael Morin, Yixian Zhang, Lee M. Greenberger, Philip Frost, Rebecca Annable
Publikováno v:
Analytical Biochemistry. 326:106-113
In response to diverse stimuli, the transcription factor NF-kappaB is activated by the IKK kinase complex containing two kinases (IKKalpha and IKKbeta) that phosphorylate IkappaB, an inhibitory protein of NF-kappaB. The phosphorylation of IkappaB res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41438599aab03be1c5ab7cfab33d55b0
https://doi.org/10.1016/j.ab.2003.11.021
https://doi.org/10.1016/j.ab.2003.11.021
Autor:
S V Johann, Morin John Edward, Bloom Jonathan David, Larocque James Paul, Boris Feld, Bryan Mark O'hara, Jeanette Fairhurst, Steven K. Vernon, Marja van Zeijl, Thomas R. Jones
Publikováno v:
Journal of Virology. 74:9054-9061
The herpesvirus family has many members that are human pathogens and make a significant contribution to morbidity and mortality associated with viral diseases. Based on criteria such as host cell specificity, oncogenicity, length of replication cycle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::983d4b882d843db3e2731003e87bc938
https://doi.org/10.1128/jvi.74.19.9054-9061.2000
https://doi.org/10.1128/jvi.74.19.9054-9061.2000
Autor:
Larocque James Paul, Yakov Gluzman, Stanley A. Lang, Mary Bradley, Ramaswamy Nilakantan, Martin Joseph Digrandi, Bloom Jonathan David, Morin John Edward, Bryan Mark O'hara, Olga Palant, Stephen J. Plotch
Publikováno v:
Journal of Virology. 73:140-151
Several compounds that specifically inhibited replication of the H1 and H2 subtypes of influenza virus type A were identified by screening a chemical library for antiviral activity. In single-cycle infections, the compounds inhibited virus-specific p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18b2077b272ca0ac8883faf7aecf5c0e
https://doi.org/10.1128/jvi.73.1.140-151.1999
https://doi.org/10.1128/jvi.73.1.140-151.1999
Autor:
James K. Hennan, Richard K. Harrison, Belew Mekonnen, Larocque James Paul, Jeff Tillett, Manoj Samuel, Jeff W. Paslay, Veronica Soloveva, Kun Liu
Publikováno v:
Journal of biomolecular screening. 15(2)
Voltage-gated K(+) channels are potential drug targets for an increasing number of disease indications. Searching for compounds that modulate K(+) channel activities by high-throughput screening (HTS) is becoming a standard approach in the drug disco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cecb0addb21e2bfbe49ffe8ed2ffea22
https://pubmed.ncbi.nlm.nih.gov/20044579
https://pubmed.ncbi.nlm.nih.gov/20044579
Autor:
Gregory Tawa, Mark R. Bowlby, John Dunlop, Larocque James Paul, Veronica Soloveva, Morin John Edward, Ravikumar Peri
Publikováno v:
Combinatorial chemistryhigh throughput screening. 11(7)
Ion channels are attractive targets for drug discovery with recent estimates indicating that voltage and ligand-gated channels account for the third and fourth largest gene families represented in company portfolios after the G protein coupled and nu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7272e9d85b5ec60aee156141e920e2ae
https://pubmed.ncbi.nlm.nih.gov/18694388
https://pubmed.ncbi.nlm.nih.gov/18694388