Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Larissa Waldman"'
Autor:
Nicholas Light, Mehdi Layeghifard, Ayush Attery, Vallijah Subasri, Matthew Zatzman, Nathaniel D. Anderson, Rupal Hatkar, Sasha Blay, David Chen, Ana Novokmet, Fabio Fuligni, James Tran, Richard de Borja, Himanshi Agarwal, Larissa Waldman, Lisa M. Abegglen, Daniel Albertson, Jonathan L. Finlay, Jordan R. Hansford, Sam Behjati, Anita Villani, Moritz Gerstung, Ludmil B. Alexandrov, Gino R. Somers, Joshua D. Schiffman, Varda Rotter, David Malkin, Adam Shlien
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Li-Fraumeni syndrome (LFS) is associated with pathogenic germline TP53 variants and predisposes patients to cancer; understanding the evolution and drivers of LFS-related tumours remains crucial. Here, the authors analyse 22 LFS tumours using whole-g
Externí odkaz:
https://doaj.org/article/6313943fa94246f49c0f01dd1873ed40
The clinical utility of integrative genomics in childhood cancer extends beyond targetable mutations
Autor:
Anita Villani, Scott Davidson, Nisha Kanwar, Winnie W. Lo, Yisu Li, Sarah Cohen-Gogo, Fabio Fuligni, Lisa-Monique Edward, Nicholas Light, Mehdi Layeghifard, Ricardo Harripaul, Larissa Waldman, Bailey Gallinger, Federico Comitani, Ledia Brunga, Reid Hayes, Nathaniel D. Anderson, Arun K. Ramani, Kyoko E. Yuki, Sasha Blay, Brittney Johnstone, Cara Inglese, Rawan Hammad, Catherine Goudie, Andrew Shuen, Jonathan D. Wasserman, Rosemarie E. Venier, Marianne Eliou, Miranda Lorenti, Carol Ann Ryan, Michael Braga, Meagan Gloven-Brown, Jianan Han, Maria Montero, Famida Spatare, James A. Whitlock, Stephen W. Scherer, Kathy Chun, Martin J. Somerville, Cynthia Hawkins, Mohamed Abdelhaleem, Vijay Ramaswamy, Gino R. Somers, Lianna Kyriakopoulou, Johann Hitzler, Mary Shago, Daniel A. Morgenstern, Uri Tabori, Stephen Meyn, Meredith S. Irwin, David Malkin, Adam Shlien
Publikováno v:
Nature Cancer. 4:203-221
We conducted integrative somatic–germline analyses by deeply sequencing 864 cancer-associated genes, complete genomes and transcriptomes for 300 mostly previously treated children and adolescents/young adults with cancer of poor prognosis or with r
Publikováno v:
Journal of Genetic Counseling
Genetic counseling services changed due to the COVID‐19 pandemic. Many genetic counselors (GCs) moved from in‐person to telehealth services. Others were redeployed by choice or necessity, using their expertise to provide COVID‐19 care and educa
Autor:
Larissa Waldman, Kelly Hancock, Bailey Gallinger, Brittney Johnstone, Ledia Brunga, David Malkin, Maru Barrera, Anita Villani
Publikováno v:
JCO Precision Oncology.
PURPOSE The SickKids Cancer Sequencing (KiCS) Program, launched in 2016, evaluates the clinical utility of paired tumor/germline Next-Generation Sequencing (NGS) in pediatric oncology patients with hard-to-cure and rare cancers. In anticipation of fu
Autor:
Amy S Kaiser, Cheryl Shuman, Iris Cohn, David Chitayat, Allison Hazell, Larissa Waldman, Syed Wasim
Publikováno v:
Pharmacogenomics. 20:319-329
Pharmacogenomic (PGx) tests represent significant advances in precision medicine. Our aim was to explore perceptions following the return of PGx results, medication management, and disclosure to providers. We surveyed clients who had PGx testing and
Autor:
Bailey Gallinger, Sarah Cohen-Gogo, Anita Villani, Stephen Meyn, Larissa Waldman, Mehdi Layeghifard, Karin Langenberg-Ververgaert, Winnie Lo, Nathaniel D. Anderson, Ted Young, David Malkin, Scott Davidson, Daniel Morgenstern, Adam Shlien, Nisha Kanwar, Meredith S. Irwin, Ledia Brunga
Publikováno v:
Cancer Research. 80:B07-B07
Background: The role of germline ALK and PHOX2B variants in genetic predisposition to neuroblastoma (NB) is well established; however, alterations in genes associated with other syndromes, including RASopathies, Fanconi anemia, and Li-Fraumeni, have