Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Larissa Traxler"'
Autor:
Larissa Traxler, Jessica Lagerwall, Sophie Eichhorner, Davide Stefanoni, Angelo D'Alessandro, Jerome Mertens
Publikováno v:
Disease Models & Mechanisms, Vol 14, Iss 8 (2021)
An uninterrupted energy supply is critical for the optimal functioning of all our organs, and in this regard the human brain is particularly energy dependent. The study of energy metabolic pathways is a major focus within neuroscience research, which
Externí odkaz:
https://doaj.org/article/36167fda9b67405caaff154a65d8e67e
Autor:
Yongsung Kim, Xinde Zheng, Zoya Ansari, Mark C. Bunnell, Joseph R. Herdy, Larissa Traxler, Hyungjun Lee, Apua C.M. Paquola, Chrysanthi Blithikioti, Manching Ku, Johannes C.M. Schlachetzki, Jürgen Winkler, Frank Edenhofer, Christopher K. Glass, Andres A. Paucar, Baptiste N. Jaeger, Son Pham, Leah Boyer, Benjamin C. Campbell, Tony Hunter, Jerome Mertens, Fred H. Gage
Publikováno v:
Cell Reports, Vol 23, Iss 9, Pp 2550-2558 (2018)
Mitochondria are a major target for aging and are instrumental in the age-dependent deterioration of the human brain, but studying mitochondria in aging human neurons has been challenging. Direct fibroblast-to-induced neuron (iN) conversion yields fu
Externí odkaz:
https://doaj.org/article/745b25dfd2684290864d22273782c442
Autor:
Joseph R. Herdy, Larissa Traxler, Ravi K. Agarwal, Lukas Karbacher, Johannes C.M. Schlachetzki, Lena Boehnke, Dina Zangwill, Doug Galasko, Christopher K. Glass, Jerome Mertens, Fred H. Gage
Publikováno v:
Cell Stem Cell
The concept of senescence as a phenomenon limited to proliferating cells has been challenged by growing evidence of senescence-like features in terminally differentiated cells, including neurons. The persistence of senescent cells late in life is ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9086903782b873f3bf38da30838300c7
https://europepmc.org/articles/PMC10093780/
https://europepmc.org/articles/PMC10093780/
Autor:
Jessica Lagerwall, Sophie Eichhorner, Larissa Traxler, Jerome Mertens, Davide Stefanoni, Angelo D'Alessandro
Publikováno v:
Disease Models & Mechanisms
article-version (VoR) Version of Record
Disease Models & Mechanisms, Vol 14, Iss 8 (2021)
article-version (VoR) Version of Record
Disease Models & Mechanisms, Vol 14, Iss 8 (2021)
An uninterrupted energy supply is critical for the optimal functioning of all our organs, and in this regard the human brain is particularly energy dependent. The study of energy metabolic pathways is a major focus within neuroscience research, which
Autor:
Larissa Traxler, Joseph R. Herdy, Davide Stefanoni, Sophie Eichhorner, Silvia Pelucchi, Attila Szücs, Alice Santagostino, Yongsung Kim, Ravi K. Agarwal, Johannes C.M. Schlachetzki, Christopher K. Glass, Jessica Lagerwall, Douglas Galasko, Fred H. Gage, Angelo D’Alessandro, Jerome Mertens
Publikováno v:
Cell Metabolism
The drivers of sporadic Alzheimer's disease (AD) remain incompletely understood. Utilizing directly converted induced neurons (iNs) from AD-patient-derived fibroblasts, we identified a metabolic switch to aerobic glycolysis in AD iNs. Pathological is
Autor:
Lucia, Zhou-Yang, Sophie, Eichhorner, Lukas, Karbacher, Lena, Böhnke, Larissa, Traxler, Jerome, Mertens
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2352
Progressive aging is a physiological process that represents a central risk factor for the development of several human age-associated chronic diseases, including neurodegenerative diseases. A major focus in biomedical research is the pursuit for app
Autor:
Daniele Repetto, Clemens L Schöpf, Markus Missler, Stefanie Geisler, Larissa Traxler, Marcus Kalb, Marta Campiglio, Ruslan Stanika, Gerald J. Obermair
Publikováno v:
The Journal of Neuroscience. 39:2581-2605
Presynaptic α2δ subunits of voltage-gated calcium channels regulate channel abundance and are involved in glutamatergic synapse formation. However, little is known about the specific functions of the individual α2δ isoforms and their role in GABA
Autor:
Sophie Eichhorner, Lena Böhnke, Jerome Mertens, Lucia Zhou-Yang, Lukas Karbacher, Larissa Traxler
Publikováno v:
Methods in Molecular Biology ISBN: 9781071616000
Progressive aging is a physiological process that represents a central risk factor for the development of several human age-associated chronic diseases, including neurodegenerative diseases. A major focus in biomedical research is the pursuit for app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9269f5cbaae3f5766abeca552062d6f
https://doi.org/10.1007/978-1-0716-1601-7_6
https://doi.org/10.1007/978-1-0716-1601-7_6
Publikováno v:
Drug Discovery Today: Disease Models. 27:43-49
With the advancing age of humans and with it, growing numbers of age-related diseases, aging has become a major focus in recent research. The lack of fitting aging models, especially in neurological diseases where access to human brain samples is lim
Autor:
Shauna H. Yuan, Johannes C. M. Schlachetzki, Fred H. Gage, Dylan A. Reid, Apuã C. M. Paquola, Raffaella Lucciola, Shani Stern, Attila Szücs, Larissa Traxler, Steve Horvath, Lena Böhnke, Douglas Galasko, Simon T. Schafer, Frank Edenhofer, Christopher K. Glass, Dina Zangwill, Lukas Karbacher, Jerome Mertens, Diana P. Fernandes, Lucia Zhou-Yang, Lawrence S.B. Goldstein, Manching Ku, Hyungjun Lee, Joseph R. Herdy, Ravi K. Agarwal
Publikováno v:
Cell Stem Cell
Summary Sporadic Alzheimer’s disease (AD) exclusively affects elderly people. Using direct conversion of AD patient fibroblasts into induced neurons (iNs), we generated an age-equivalent neuronal model. AD patient-derived iNs exhibit strong neurona